Protein Alignment Tis11 and Zfp36l1

DIOPT Version :10

• Sequence 1: NP_511141.2
• Gene: Tis11 / 32222
• FlyBaseID: FBgn0011837
• Length: 436
• Species: Drosophila melanogaster
• Sequence 2: NP_058868.1
• Gene: Zfp36l1 / 29344
• RGDID: 62009
• Length: 338
• Species: Rattus norvegicus
• Alignment Length: 400
• Identity: 128/400 - (32%)
• Similarity: 180/400 - (45%)
• Gaps: 89/400 - (22%)

  Fly    36 FDCNEVR-KEIRML-----LAHGANLDQQHQQQPHRHHGGLTR--TISQPAQLIQQQQQQHQQQQ 92
            ||.:||. |..:||     .|.|..||::....|  ..||..|  :::.|:....|.|.....:.
  Rat    11 FDLSEVLCKGNKMLNYSTPSAGGCLLDRKAVGTP--AGGGFPRRHSVTLPSSKFHQNQLLSSLKG 73

  Fly    93 QQQPAVASLVTITENLGNMNLHRKLERTQSEPLPPQQPMNTSRYKTELCRPFEEAGECKYGEKCQ 157
            :..|.::|..:...:........:|..||.:|...|  :|:|||||||||||||.|.||||:|||
  Rat    74 EPAPTLSSRDSRFRDRSFSEGGERLLPTQKQPGSGQ--VNSSRYKTELCRPFEENGACKYGDKCQ 136

  Fly   158 FAHGSHELRNVHRHPKYKTEYCRTFHSVGFCPYGPRCHFVHNADEARAQQAAQAAKSSTQSQSQS 222
            ||||.||||::.||||||||.|||||::|||||||||||:|||:|.||     .|.....|..:.
  Rat   137 FAHGIHELRSLTRHPKYKTELCRTFHTIGFCPYGPRCHFIHNAEERRA-----LAGGRDLSADRP 196

  Fly   223 QQSSSQNFSPKSNQSSNQSSNSSSSSSSSGGGGGGGNSINNNNGSQFYLPLSPPLSMSTGSDRES 287
            :...|.:|:...:.::..::.....|.:|                     ::||..:|......|
  Rat   197 RLQHSFSFAGFPSAAATAAATGLLDSPTS---------------------ITPPPILSADDLLGS 240

  Fly   288 PTGSLSLSPTNSLTSFPFHDALQHGYLASNGAKSNSSASSTSSASGMGLGMSMGIGQGMIIGQGL 352
            ||     .|..:...|.|                :|...::..|..|||
  Rat   241 PT-----LPDGTNNPFAF----------------SSQELASLFAPSMGL---------------- 268

  Fly   353 GMGHHGPAT-----PPESPNVPISPVHTPPPYDVVVSGSGAGNNSVGSKQLLQKSVSTPMQQEDT 412
             .|...|.|     ..|||::..||   |.|.|.:....|..::|..|     .|.|.....:::
  Rat   269 -PGGGSPTTFLFRPMSESPHMFDSP---PSPQDSLSDHEGYLSSSSSS-----HSGSDSPTLDNS 324

  Fly   413 PRLPVFNRLS 422
            .|||:|:|||
  Rat   325 RRLPIFSRLS 334

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tis11	NP_511141.2	CTH1	<121..>198	CDD:227395	57/76 (75%)
Zfp36l1	NP_058868.1	Necessary and sufficient for the association with mRNA decay enzymes and mRNA decay activation. /evidence=ECO:0000250|UniProtKB:Q07352	1..111		25/103 (24%)
		Tis11B_N	1..107	CDD:461350	24/97 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	93..113		6/21 (29%)
		CTH1	<115..>177	CDD:227395	51/61 (84%)
		Necessary for mRNA decay activation. /evidence=ECO:0000250|UniProtKB:Q07352	185..338		42/216 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	273..338		21/69 (30%)