Protein Alignment Tis11 and Zfp36

DIOPT Version :10

• Sequence 1: NP_511141.2
• Gene: Tis11 / 32222
• FlyBaseID: FBgn0011837
• Length: 436
• Species: Drosophila melanogaster
• Sequence 2: NP_035886.1
• Gene: Zfp36 / 22695
• MGIID: 99180
• Length: 319
• Species: Mus musculus
• Alignment Length: 307
• Identity: 103/307 - (33%)
• Similarity: 129/307 - (42%)
• Gaps: 70/307 - (22%)

  Fly   118 ERTQSEPLPPQQPMNTSRYKTELCRPFEEAGECKYGEKCQFAHGSHELRNVHRHPKYKTEYCRTF 182
            |.:.|...|...|..:|||||||||.:.|:|.|:||.|||||||..|||..:||||||||.|..|
Mouse    78 ELSPSPTSPTATPTTSSRYKTELCRTYSESGRCRYGAKCQFAHGLGELRQANRHPKYKTELCHKF 142

  Fly   183 HSVGFCPYGPRCHFVHNADEARAQQAAQAAKSSTQSQSQSQQSSSQNFSPKSNQSSNQSSNSSSS 247
            :..|.||||.||||:||..|..|.......  ..||.|.|...|.:..||.....|..|.:|.|.
Mouse   143 YLQGRCPYGSRCHFIHNPTEDLALPGQPHV--LRQSISFSGLPSGRRSSPPPPGFSGPSLSSCSF 205

  Fly   248 SSSSGGGGGGGNSINNNNGSQFYLPLSPPLSMSTGSDRESPTGSLSLSPTNSLTSFPFHDALQHG 312
            |.||                      |||           |.|.|.||| ::.::.|.....:..
Mouse   206 SPSS----------------------SPP-----------PPGDLPLSP-SAFSAAPGTPVTRRD 236

  Fly   313 YLASNGAKSNSSASSTSSASGMG-LGMSMGIGQGMIIGQGLGMGHHGPATPPESPNVPISPVHTP 376
               .|.|...|...||:.::..| ||                    |.|..|.:.::      ..
Mouse   237 ---PNQACCPSCRRSTTPSTIWGPLG--------------------GLARSPSAHSL------GS 272

  Fly   377 PPYDVVVSGSGAGNNSVGSKQLLQKSVSTPMQQEDTP-RLPVFNRLS 422
            .|.|...|||..|.:   ...:.:..|..|.|....| |||:|||:|
Mouse   273 DPDDYASSGSSLGGS---DSPVFEAGVFGPPQTPAPPRRLPIFNRIS 316

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tis11	NP_511141.2	CTH1	<121..>198	CDD:227395	46/76 (61%)
Zfp36	NP_035886.1	Necessary for localization of ARE-containing mRNAs to processing bodies (PBs). /evidence=ECO:0000250|UniProtKB:P26651	1..166		50/87 (57%)
		Necessary and sufficient for the association with mRNA decay enzymes and mRNA decay activation. /evidence=ECO:0000250|UniProtKB:P26651	1..92		4/13 (31%)
		Necessary for nuclear export. /evidence=ECO:0000250|UniProtKB:P47973	1..15
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	65..95		4/16 (25%)
		Necessary for nuclear localization. /evidence=ECO:0000250|UniProtKB:P47973	87..160		45/72 (63%)
		Necessary for RNA-binding. /evidence=ECO:0000250|UniProtKB:P26651	89..165		47/75 (63%)
		Necessary for localization of ARE-containing mRNAs to processing bodies (PBs). /evidence=ECO:0000250|UniProtKB:P26651	92..319		99/293 (34%)
		Necessary for interaction with PABPN1. /evidence=ECO:0000269|PubMed:22844456	95..186		51/92 (55%)
		CTH1	<96..>166	CDD:227395	44/69 (64%)
		Necessary for mRNA decay activation. /evidence=ECO:0000250|UniProtKB:P26651	166..319		52/219 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	179..309		42/195 (22%)
		Interaction with CNOT1. /evidence=ECO:0000250|UniProtKB:P26651	305..319		8/12 (67%)