Protein Alignment Tis11 and mex-5

DIOPT Version :10

• Sequence 1: NP_511141.2
• Gene: Tis11 / 32222
• FlyBaseID: FBgn0011837
• Length: 436
• Species: Drosophila melanogaster
• Sequence 2: NP_502566.1
• Gene: mex-5 / 178296
• WormBaseID: WBGene00003230
• Length: 468
• Species: Caenorhabditis elegans
• Alignment Length: 445
• Identity: 97/445 - (21%)
• Similarity: 140/445 - (31%)
• Gaps: 182/445 - (40%)

  Fly    11 EQDDSHYF--------------ERGDISKYVTMNDHLGDFDCNEVRKEIRMLLAHGANLDQQHQQ 61
            :|...:||              :.|...:|.....:..|.:...|:     :.|:|:...|||..
 Worm    36 DQQMQYYFAAAMPNQPMATYAAQNGSSQQYAPAAPYYQDANGQYVQ-----VPANGSMAPQQHMM 95

  Fly    62 ---QPHRHHGGLTRTISQPAQLIQQQQQQHQQQ-------------------------------- 91
               ||:.:       ::||.|..||..|..|.|
 Worm    96 VSGQPYLY-------MAQPQQGAQQVMQSGQPQLIYYQQSMAPQAAPMYFHPMQAAPMLPEQMGV 153

  Fly    92 ---------QQQQP----------AVASLV------------TITENLGNMNL----HRKLER-- 119
                     .||||          ..|.|.            |:..:..|.|:    ||.:|.
 Worm   154 MPHTQPAIPPQQQPRQVGVEISSTRTAPLTSSTPLPTSLEYETVQRDNRNRNIQFRYHRVMEHDE 218

  Fly   120 -----------------TQSE-------------------PLP---PQQPMNTSRYKTELCRPFE 145
                             |.|.                   |:|   .|||.|   |||.||. ..
 Worm   219 LPIDEISKITLDNHNDDTMSAEKENHFHEHRGEKFGRRGFPIPETDSQQPPN---YKTRLCM-MH 279

  Fly   146 EAG--ECKYGEKCQFAHGSHELRNVH---RHP--KYKTEYCRTF--HSVGFCPYGPRCHFVHNAD 201
            .:|  .|..|.:|:||||..|||...   |:|  ||||:.|:.|  ...||||||.||.|||..|
 Worm   280 ASGIKPCDMGARCKFAHGLKELRATDAPARYPNNKYKTKLCKNFARGGTGFCPYGLRCEFVHPTD 344

  Fly   202 EARAQQAAQAAKSSTQSQSQSQQSSSQNF-----SPKSNQSSNQS-------------SNSSSSS 248
            : ..|......:.|...|...|....:::     .|:..::..::             :.|....
 Worm   345 K-EFQNIPPYQRMSHDDQDYDQDVIPEDYVVARHQPRFMRTGGRATTPTKVMLKHRNVAGSMMCL 408

  Fly   249 SSSGGGGGGGNSINNNNGSQFYLP--------LSPPL-----SMSTGSDRESPTG 290
            |::|.....|...|....::..||        .:||:     |:||....|...|
 Worm   409 SNAGRDLQAGGDYNQPESNEDDLPPHLRRNRRENPPMNKRRTSLSTKWTSEENLG 463

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tis11	NP_511141.2	CTH1	<121..>198	CDD:227395	40/107 (37%)
mex-5	NP_502566.1	PRK10263	<47..>155	CDD:236669	19/119 (16%)
		CTH1	<181..341	CDD:227395	48/163 (29%)
		zf-CCCH	315..342	CDD:459885	15/26 (58%)