DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tis11 and Zfp36l2

DIOPT Version :9

Sequence 1:	NP_001259490.1	Gene:	Tis11 / 32222	FlyBaseID:	FBgn0011837	Length:	436	Species:	Drosophila melanogaster
Sequence 2:	NP_001001806.1	Gene:	Zfp36l2 / 12193	MGIID:	107945	Length:	484	Species:	Mus musculus

Alignment Length:	427	Identity:	128/427 - (29%)
Similarity:	172/427 - (40%)	Gaps:	144/427 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 QQQQPAVAS---LVTITENLGNMNLHRKLERTQS-EPLPPQQ------PMNTSRYKTELCRPFEE 146
            |.::|:..|   |||......:.:.....||:|. ..|..||      .:|::||||||||||||
Mouse   102 QLKEPSGGSGTALVTKESKFRDRSFSENGERSQHLLHLQQQQKGGSGSQINSTRYKTELCRPFEE 166

  Fly   147 AGECKYGEKCQFAHGSHELRNVHRHPKYKTEYCRTFHSVGFCPYGPRCHFVHNADEARAQQAAQA 211
            :|.||||||||||||.||||::.||||||||.|||||::|||||||||||:|||||.|...:...
Mouse   167 SGTCKYGEKCQFAHGFHELRSLTRHPKYKTELCRTFHTIGFCPYGPRCHFIHNADERRPAPSGGG 231

  Fly   212 AKSSTQSQSQSQQSSSQNFS----PKSNQSSNQSSNSSSSSSSSGGGGGGGNSINNNNGSQFYLP 272
            ..|.......::.:....|:    ||.:.|.:.|...|......||
Mouse   232 GASGDLRAFGARDALHLGFAREPRPKLHHSLSFSGFPSGHHQPPGG------------------- 277

  Fly   273 LSPPLSMSTGSDRESPTGSLSLSPTNSLTSFPFHDALQHGYLASNGAKSNSSASSTSSASGMGLG 337
            |..||.:      :|||......|::|.:|            .|:.|.|.||||:.|:.||....
Mouse   278 LESPLLL------DSPTSRTPPPPSSSASS------------CSSSASSCSSASAASTPSGAPTC 324

  Fly   338 MSMGIGQGMIIGQG------------------------------------LGMGHH--------- 357
            .:......::.|.|                                    |.:..|
Mouse   325 CATAAAAALLYGPGGAEDLLSPGAPCASCSSSGANNAFAFGPELSSLITPLAIQTHNFAAAAAAA 389

  Fly   358 ----------GPATPPESPNVPISPVHTPPPY---------------------------DVVVSG 385
                      |||.||..|  |.:|....||:                           |..:||
Mouse   390 YYRNQQQGLTGPAPPPAQP--PAAPAPPSPPFGFQLPRRLSESPVFDAPPSPPDSLSDRDSYLSG 452

  Fly   386 SGAGNNSVGSKQLLQKSVSTPMQQEDTPRLPVFNRLS 422
            |.:..:..||:        :| ..:...|||:|:|||
Mouse   453 SLSSGSLSGSE--------SP-SLDPGRRLPIFSRLS 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tis11	NP_001259490.1	zf-CCCH	136..161	CDD:279036	22/24 (92%)
Tis11	NP_001259490.1	zf-CCCH	174..198	CDD:279036	20/23 (87%)
Zfp36l2	NP_001001806.1	Tis11B_N	3..133	CDD:282420	7/30 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	100..152		12/49 (24%)
		RNA-binding. /evidence=ECO:0000250\|UniProtKB:P47974	155..160		4/4 (100%)
		zf-CCCH	156..181	CDD:279036	22/24 (92%)
		RNA-binding. /evidence=ECO:0000250\|UniProtKB:P47974	172..213		33/40 (83%)
		zf-CCCH	194..218	CDD:279036	20/23 (87%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	261..304		14/79 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	395..484		24/97 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	61	1.000	Domainoid score	I10408
eggNOG	1	0.900	-	-		E1_COG5063
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	158	1.000	Inparanoid score	I4247
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000616
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12547
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2078
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.950