DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CkIalpha and YCK2

DIOPT Version :9

Sequence 1:	NP_001162737.1	Gene:	CkIalpha / 32221	FlyBaseID:	FBgn0015024	Length:	337	Species:	Drosophila melanogaster
Sequence 2:	NP_014245.1	Gene:	YCK2 / 855568	SGDID:	S000005098	Length:	546	Species:	Saccharomyces cerevisiae

Alignment Length:	343	Identity:	164/343 - (47%)
Similarity:	209/343 - (60%)	Gaps:	20/343 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 ESRPE-IIVGGKYRVIRKIGSGSFGDIYLGMSIQSGEEVAIKMESAHARHPQLLYEAKLYRILSG 72
            :||.: .|||..|::.:|||.||||.::.|.::.:|..||||.|......|||..|.:.|:||:|
Yeast    64 QSRDDSTIVGLHYKIGKKIGEGSFGVLFEGTNMINGLPVAIKFEPRKTEAPQLKDEYRTYKILAG 128

  Fly    73 GVGFPRIRHHGKEKNFNTLVMDLLGPSLEDLFNFCTRHFTIKTVLMLVDQMIGRLEYIHLKCFIH 137
            ..|.|:..:.|:|...|.||:|||||||||||::|.|.|::|||:.:..|||..:|.:|....|:
Yeast   129 TPGIPQEYYFGQEGLHNILVIDLLGPSLEDLFDWCGRRFSVKTVVQVAVQMITLIEDLHAHDLIY 193

  Fly   138 RDIKPDNFLMGIGR----HCNKLFLIDFGLAKKFRDPHTRHHIVYREDKNLTGTARYASINAHLG 198
            |||||||||  |||    ..||:.|||||:||::|||.|:.||.|||.|:|:|||||.|||.|||
Yeast   194 RDIKPDNFL--IGRPGQPDANKVHLIDFGMAKQYRDPKTKQHIPYREKKSLSGTARYMSINTHLG 256

  Fly   199 IEQSRRDDMESLGYVMMYFNRGVLPWQGMKANTKQQKYEKISEKKMSTPIEVLCKGSPAEFSMYL 263
            .|||||||||::|:|..||.||.|||||:||...:||||||.|||..|.:..|.:|.|.:|..||
Yeast   257 REQSRRDDMEAMGHVFFYFLRGQLPWQGLKAPNNKQKYEKIGEKKRLTNVYDLAQGLPIQFGRYL 321

  Fly   264 NYCRSLRFEEQPDYMYLRQLFRILFRTLNHQYDYIYDWTML------------KQKTH-QGQPNP 315
            ...|:|.|||.|||...|.|...:...|....|..|||..|            |...| .|.|||
Yeast   322 EIVRNLSFEETPDYEGYRMLLLSVLDDLGETADGQYDWMKLNGGRGWDLSINKKPNLHGYGHPNP 386

  Fly   316 AILLEQLDKDKEKQNGKP 333
            .....:..:.|..|...|
Yeast   387 PNEKSKRHRSKNHQYSSP 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CkIalpha	NP_001162737.1	PKc_like	19..284	CDD:304357	143/268 (53%)
CkIalpha	NP_001162737.1	Pkinase_Tyr	23..284	CDD:285015	142/264 (54%)
YCK2	NP_014245.1	STKc_CK1_fungal	75..351	CDD:271029	145/277 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344366
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.700