DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CkIalpha and VRK2

DIOPT Version :9

Sequence 1:	NP_001162737.1	Gene:	CkIalpha / 32221	FlyBaseID:	FBgn0015024	Length:	337	Species:	Drosophila melanogaster
Sequence 2:	NP_001123952.1	Gene:	VRK2 / 7444	HGNCID:	12719	Length:	508	Species:	Homo sapiens

Alignment Length:	300	Identity:	93/300 - (31%)
Similarity:	152/300 - (50%)	Gaps:	46/300 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 GGKYRVIRKIGSGSFGDIYLGMSIQSGEEVA---IKMESAHARHPQLLYEAKLYRILS------- 71
            |.::.:.:|||||.||.|||.......|:.|   :|:|  :..:..|..|.|.|:.::
Human    26 GNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVE--YQENGPLFSELKFYQRVAKKDCIKK 88

  Fly    72 -------GGVGFPRIRHHG----KEKNFNTLVMDLLGPSLEDLFNFCTRHFTIK--TVLMLVDQM 123
                   ..:|.|.....|    |.:::..:||:.||..|:.:..   ::.|.|  |||.|..:|
Human    89 WIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISG---QNGTFKKSTVLQLGIRM 150

  Fly   124 IGRLEYIHLKCFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKFRDPHTRHHIVYRED--KNLTG 186
            :..|||||...::|.|||..|.|:|. ::.::::|.|:||:  :|.....:|..|:|:  |...|
Human   151 LDVLEYIHENEYVHGDIKAANLLLGY-KNPDQVYLADYGLS--YRYCPNGNHKQYQENPRKGHNG 212

  Fly   187 TARYASINAHLGIEQSRRDDMESLGYVMMYFNRGVLPW-QGMKANTKQQ--KYEKISEKKMSTPI 248
            |..:.|::||.|:..|||.|:|.|||.|:.:..|.||| |.:|.....|  |...:.|    .|.
Human   213 TIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDE----LPQ 273

  Fly   249 EVLCKGSPA-----EFSMYLNYCRSLRFEEQPDYMYLRQL 283
            .|| |.:|:     |.:.:|....||.::|:|:|..|:::
Human   274 SVL-KWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKI 312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CkIalpha	NP_001162737.1	PKc_like	19..284	CDD:304357	92/297 (31%)
CkIalpha	NP_001162737.1	Pkinase_Tyr	23..284	CDD:285015	92/293 (31%)
VRK2	NP_001123952.1	STKc_VRK2	16..314	CDD:271025	93/299 (31%)
		SPS1	29..421	CDD:223589	92/296 (31%)
		Interaction with MAP3K7. /evidence=ECO:0000269\|PubMed:17709393	397..508
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810