DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CkIalpha and ttbk2b

DIOPT Version :9

Sequence 1:	NP_001162737.1	Gene:	CkIalpha / 32221	FlyBaseID:	FBgn0015024	Length:	337	Species:	Drosophila melanogaster
Sequence 2:	NP_001313220.1	Gene:	ttbk2b / 569881	ZFINID:	ZDB-GENE-030131-8246	Length:	928	Species:	Danio rerio

Alignment Length:	319	Identity:	107/319 - (33%)
Similarity:	159/319 - (49%)	Gaps:	23/319 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 IVGGKYRVIRKIGSGSFGDIYLGMSIQSGEEVAIKMESAHARHPQLLYEAKLYRILSGGVGFPRI 79
            :|..::||::|||.|.||:||..:...:...||:|:|||......|..|..:.:.|.|.....|.
Zfish    16 MVRERWRVLKKIGGGGFGEIYEVLDHVNQVSVALKVESAQQPKQVLKMEVAVLKRLQGKDHVCRF 80

  Fly    80 RHHGKEKNFNTLVMDLLGPSLEDL-FNFCTRHFTIKTVLMLVDQMIGRLEYIHLKCFIHRDIKPD 143
            ...|:...||.:||:|.|.:|.|| .|.....|::.|.|.|..|::..:|.||...|:||||||.
Zfish    81 VGCGRNDRFNYVVMELQGRNLADLRRNMSHGTFSVSTTLRLGRQILEAIESIHSVGFLHRDIKPS 145

  Fly   144 NFLMG-IGRHCNKLFLIDFGLAKKF-------RDPHTRHHIVYREDKNLTGTARYASINAHLGIE 200
            ||.|| :...|...:::|||||::|       |.|        |......||.||||||||...|
Zfish   146 NFAMGRLNSTCRTCYMLDFGLARQFTNSCQEVRPP--------RPVAGFRGTVRYASINAHKNKE 202

  Fly   201 QSRRDDMESLGYVMMYFNRGVLPWQGMKANTKQQKYEKISEKKMSTPIEVLCKGSPAEFSMYLNY 265
            ..|.||:.||.|:::.|..|.|||:.:|..      |::...|.:....:|.|..|.|||::.::
Zfish   203 MGRHDDLWSLFYMLVEFMVGQLPWRKIKDK------EQVGNMKETYNHRLLLKHLPDEFSVFFDH 261

  Fly   266 CRSLRFEEQPDYMYLRQLFRILFRTLNHQYDYIYDWTMLKQKTHQGQPNPAILLEQLDK 324
            ..:|.:..:|||..|..:|....::.|...:..|||..|..:........|...:||.:
Zfish   262 ISNLDYYTKPDYQLLMSVFDNSMKSYNVVENDPYDWEKLDSEDTLNVGTLATTAQQLTR 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CkIalpha	NP_001162737.1	PKc_like	19..284	CDD:304357	97/273 (36%)
CkIalpha	NP_001162737.1	Pkinase_Tyr	23..284	CDD:285015	95/269 (35%)
ttbk2b	NP_001313220.1	STKc_TTBK	20..281	CDD:270919	97/274 (35%)
ttbk2b	NP_001313220.1	SPS1	21..361	CDD:223589	106/314 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810