DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CkIalpha and csnk1g2a

DIOPT Version :9

Sequence 1:	NP_001162737.1	Gene:	CkIalpha / 32221	FlyBaseID:	FBgn0015024	Length:	337	Species:	Drosophila melanogaster
Sequence 2:	XP_005171263.1	Gene:	csnk1g2a / 554152	ZFINID:	ZDB-GENE-030131-6445	Length:	452	Species:	Danio rerio

Alignment Length:	331	Identity:	158/331 - (47%)
Similarity:	222/331 - (67%)	Gaps:	23/331 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 IIVGGKYRVIRKIGSGSFGDIYLGMSIQSGEEVAIKMESAHARHPQLLYEAKLYRILSGGVGFPR 78
            ::||..:||.:|||.|:||::.||.::.:.|.||||:|...:|.|||..|.:.|:.|....|.|:
Zfish    44 LMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLGNAEGVPQ 108

  Fly    79 IRHHGKEKNFNTLVMDLLGPSLEDLFNFCTRHFTIKTVLMLVDQMIGRLEYIHLKCFIHRDIKPD 143
            :.:.|....:|.:|::||||||||||:.|.|.|::|||||:..|:|.|:|::|.:..|:||:||:
Zfish   109 VYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLITRMEFVHTRSLIYRDVKPE 173

  Fly   144 NFLMGIGRHCNK----LFLIDFGLAKKFRDPHTRHHIVYREDKNLTGTARYASINAHLGIEQSRR 204
            |||  :||...|    :.:|||||||::.||.|:.||.|||.|:|||||||.|||.|||.|||||
Zfish   174 NFL--VGRPGTKRQHTIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRR 236

  Fly   205 DDMESLGYVMMYFNRGVLPWQGMKANTKQQKYEKISEKKMSTPIEVLCKGSPAEFSMYLNYCRSL 269
            ||:|:||::.|||.||.|||||:||:|.:::|:||.:.|.:|||||||:..| |.:.||.|.|.|
Zfish   237 DDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCESFP-EMATYLRYVRRL 300

  Fly   270 RFEEQPDYMYLRQLFRILFRTLNHQYDYIYDWTMLKQKTHQGQPNPAIL--------LEQLDKDK 326
            .|.|:|||.|||:||..||....:.:||.|||.        |:|.|..:        |:..::||
Zfish   301 DFFERPDYEYLRKLFTDLFDRNGYVFDYEYDWV--------GKPLPTPIGPMPSDTPLQPSNRDK 357

  Fly   327 EKQNGK 332
            .:...|
Zfish   358 AQPQTK 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CkIalpha	NP_001162737.1	PKc_like	19..284	CDD:304357	140/268 (52%)
CkIalpha	NP_001162737.1	Pkinase_Tyr	23..284	CDD:285015	138/264 (52%)
csnk1g2a	XP_005171263.1	SPS1	49..415	CDD:223589	156/326 (48%)
		STKc_CK1_gamma	49..335	CDD:271028	149/296 (50%)
		CK1gamma_C	335..411	CDD:289378	6/29 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810