DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CkIalpha and vrk3

DIOPT Version :9

Sequence 1:	NP_001162737.1	Gene:	CkIalpha / 32221	FlyBaseID:	FBgn0015024	Length:	337	Species:	Drosophila melanogaster
Sequence 2:	NP_001013586.1	Gene:	vrk3 / 541443	ZFINID:	ZDB-GENE-030131-246	Length:	459	Species:	Danio rerio

Alignment Length:	224	Identity:	68/224 - (30%)
Similarity:	107/224 - (47%)	Gaps:	14/224 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 KLYRILSGGVGFPRIRHHGKEKNFNTLVMDLLGPSLEDLFNFCTRHFTIKTVLMLVDQMIGRLEY 129
            ||:::  ..:|.|.....|..:.:..||...:|..|:...:..|...:.|.||.|..:::..||:
Zfish   228 KLHKL--DFLGIPSCVGFGLHETYRFLVFPCMGQPLQTELDEGTGSLSEKNVLQLALRLLDSLEF 290

  Fly   130 IHLKCFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKFRDPHTRHHIVYREDKNLT--GTARYAS 192
            ||.|.:.|.||...|..:....| .::||..||.|  ||......|:.||:.....  |...:.|
Zfish   291 IHEKEYAHADIHAGNIYIKSSSH-TEVFLSGFGHA--FRFCPGGKHVEYRQGSRTAHQGNISFIS 352

  Fly   193 INAHLGIEQSRRDDMESLGYVMMYFNRGVLPWQGMKANTKQQKYEKISEKKMSTPIEVL--C--- 252
            :::|.|...|||.|::||||.|:.:..|.|||..:..|:.....||  |:.||....:|  |
Zfish   353 LDSHKGAGPSRRSDLQSLGYCMLCWMTGSLPWSHLSHNSSSVAAEK--ERYMSDVPGLLTYCYKQ 415

  Fly   253 KGSPAEFSMYLNYCRSLRFEEQPDYMYLR 281
            |.:.:....||....:|::.|:|||..|:
Zfish   416 KKASSALQEYLCNVMALQYTEKPDYTLLK 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CkIalpha	NP_001162737.1	PKc_like	19..284	CDD:304357	68/224 (30%)
CkIalpha	NP_001162737.1	Pkinase_Tyr	23..284	CDD:285015	68/224 (30%)
vrk3	NP_001013586.1	DUF4758	<9..>104	CDD:292572
		PK_VRK3	154..451	CDD:271026	68/224 (30%)
		SPS1	236..>384	CDD:223589	47/150 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810