DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CkIalpha and csnk1a1

DIOPT Version :9

Sequence 1:	NP_001162737.1	Gene:	CkIalpha / 32221	FlyBaseID:	FBgn0015024	Length:	337	Species:	Drosophila melanogaster
Sequence 2:	XP_012814233.1	Gene:	csnk1a1 / 407897	XenbaseID:	XB-GENE-478121	Length:	365	Species:	Xenopus tropicalis

Alignment Length:	358	Identity:	253/358 - (70%)
Similarity:	281/358 - (78%)	Gaps:	36/358 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 SRPEIIVGGKYRVIRKIGSGSFGDIYLGMSIQSGEEVAIKMESAHARHPQLLYEAKLYRILSGGV 74
            |:.|.||||||:::|||||||||||||.::|.:|||||:|:||..|||||||||:|||:||.|||
Frog     7 SKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGV 71

  Fly    75 GFPRIRHHGKEKNFNTLVMDLLGPSLEDLFNFCTRHFTIKTVLMLVDQMIGRLEYIHLKCFIHRD 139
            |.|.||.:|:||::|.|||||||||||||||||:|.||:||||||.||||.|:||:|.|.|||||
Frog    72 GIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRD 136

  Fly   140 IKPDNFLMGIGRHCNK----------------------------LFLIDFGLAKKFRDPHTRHHI 176
            ||||||||||||||||                            |||||||||||:||..||.||
Frog   137 IKPDNFLMGIGRHCNKCLESPVGKRKRSMTVSTSQDPSFSGLNQLFLIDFGLAKKYRDNRTRQHI 201

  Fly   177 VYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVMMYFNRGVLPWQGMKANTKQQKYEKISE 241
            .||||||||||||||||||||||||||||||||||||:|||||..|||||:||.||:||||||||
Frog   202 PYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISE 266

  Fly   242 KKMSTPIEVLCKGSPAEFSMYLNYCRSLRFEEQPDYMYLRQLFRILFRTLNHQYDYIYDWTMLKQ 306
            ||||||:||||||.||||:|||||||.|||||.|||||||||||||||||||||||.:|||||||
Frog   267 KKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQ 331

  Fly   307 K--------THQGQPNPAILLEQLDKDKEKQNG 331
            |        :.|||.......:|.||.|....|
Frog   332 KAAQQAASSSGQGQQAQTPTGKQTDKSKSNMKG 364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CkIalpha	NP_001162737.1	PKc_like	19..284	CDD:304357	216/292 (74%)
CkIalpha	NP_001162737.1	Pkinase_Tyr	23..284	CDD:285015	214/288 (74%)
csnk1a1	XP_012814233.1	STKc_CK1_alpha	16..309	CDD:271030	216/292 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	355	1.000	Domainoid score	I989
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H111694
Inparanoid	1	1.050	506	1.000	Inparanoid score	I1304
OMA	1	1.010	-	-		QHG54222
OrthoDB	1	1.010	-	-		D1097975at2759
OrthoFinder	1	1.000	-	-		FOG0000297
OrthoInspector	1	1.000	-	-		oto103203
Panther	1	1.100	-	-	LDO	PTHR11909
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3408
SonicParanoid	1	1.000	-	-		X224
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	13.110