DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CkIalpha and vrk1

DIOPT Version :9

Sequence 1:	NP_001162737.1	Gene:	CkIalpha / 32221	FlyBaseID:	FBgn0015024	Length:	337	Species:	Drosophila melanogaster
Sequence 2:	NP_998550.1	Gene:	vrk1 / 406694	ZFINID:	ZDB-GENE-040426-2709	Length:	425	Species:	Danio rerio

Alignment Length:	362	Identity:	99/362 - (27%)
Similarity:	160/362 - (44%)	Gaps:	52/362 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RILKESRP--EIIVGG---KYRVIRKIGSGSFGDIYLGMSIQSGEEVA-----IKMESA------ 53
            |.|.|..|  |::...   |:::...:|.|.||.:||.....||...|     ||:|.:
Zfish    18 RKLAEEFPSGEVLTDNAKKKWKLGSAVGQGGFGLLYLANEDSSGPVTADAPYVIKVEPSDNGPLF 82

  Fly    54 -------HARHPQLL---YEAKLYRILS----GGVGFPRIRHHGKEKNFNTLVMDLLGPSLEDLF 104
                   .|..|.|:   .::|....|.    .|.||    |....|.:..:|||..|..|:.||
Zfish    83 SELKFYMRAAKPDLIGAWMKSKKMEYLGVPKYWGSGF----HEKNGKRYRFMVMDRFGTDLQKLF 143

  Fly   105 NFCTRHFTIKTVLMLVDQMIGRLEYIHLKCFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKFRD 169
            ....:.|:.|.||.|..:::..|||||...::|.|||..|.|:.. .:.|::||:|:|||.::..
Zfish   144 EGNGKKFSRKLVLQLGLRLLDILEYIHDHEYVHADIKASNLLLSY-TNPNQVFLVDYGLAYRYAP 207

  Fly   170 PHTRHHIVYREDKNL--TGTARYASINAHLGIEQSRRDDMESLGYVMMYFNRGVLPWQGMKANTK 232
            ......  |:||...  .||..:.||:||.|:..|||.|:|.:||.|:.:....|||:.   ..:
Zfish   208 EGVPKE--YKEDPKRCHDGTIEFTSIDAHKGVSPSRRADLEIMGYCMIQWLCSRLPWED---KLQ 267

  Fly   233 QQKYEKISEKKMSTPIEVLCKGS------PAEFSMYLNYCRSLRFEEQPDYMYLRQLFRILFRTL 291
            ...|.:.|:.:....|:...|..      |||...::...:.|.:.::|||..||.:.:...:::
Zfish   268 DPLYVRDSKLRCRDNIDEFLKSCFASGNIPAEMGKFMQEVKVLGYTDRPDYDKLRGILQQGLKSI 332

  Fly   292 NHQYDYIYDWTMLKQKTHQGQPNPAILLEQLDKDKEK 328
            ....|...|:.:....|..    |::...:..|.:||
Zfish   333 GSTDDKKLDFGVATNSTSL----PSVKTPKRKKAEEK 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CkIalpha	NP_001162737.1	PKc_like	19..284	CDD:304357	87/297 (29%)
CkIalpha	NP_001162737.1	Pkinase_Tyr	23..284	CDD:285015	86/293 (29%)
vrk1	NP_998550.1	PKc_like	27..327	CDD:304357	88/309 (28%)
		SPS1	37..>265	CDD:223589	74/237 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	343..425		5/27 (19%)
		GAGA_bind	<373..>424	CDD:283799
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810