DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CkIalpha and csnk1db

DIOPT Version :9

Sequence 1:	NP_001162737.1	Gene:	CkIalpha / 32221	FlyBaseID:	FBgn0015024	Length:	337	Species:	Drosophila melanogaster
Sequence 2:	NP_998415.1	Gene:	csnk1db / 406533	ZFINID:	ZDB-GENE-040426-2385	Length:	409	Species:	Danio rerio

Alignment Length:	318	Identity:	205/318 - (64%)
Similarity:	255/318 - (80%)	Gaps:	7/318 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 EIIVGGKYRVIRKIGSGSFGDIYLGMSIQSGEEVAIKMESAHARHPQLLYEAKLYRILSGGVGFP 77
            |:.||.:||:.||||||||||||||..|..|||||||:|....:||||..|:|:|:::.||||.|
Zfish     2 ELRVGNRYRLGRKIGSGSFGDIYLGTDISVGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIP 66

  Fly    78 RIRHHGKEKNFNTLVMDLLGPSLEDLFNFCTRHFTIKTVLMLVDQMIGRLEYIHLKCFIHRDIKP 142
            .|:..|.|.::|.:||:|||||||||||||:|.|::||||:|.||||.|:||||.|.|||||:||
Zfish    67 TIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKP 131

  Fly   143 DNFLMGIGRHCNKLFLIDFGLAKKFRDPHTRHHIVYREDKNLTGTARYASINAHLGIEQSRRDDM 207
            ||||||:|:..|.:::||||||||:||..|..||.|||:|||||||||||||.|||||||||||:
Zfish   132 DNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDL 196

  Fly   208 ESLGYVMMYFNRGVLPWQGMKANTKQQKYEKISEKKMSTPIEVLCKGSPAEFSMYLNYCRSLRFE 272
            ||||||:||||.|.|||||:||.||:||||:||||||||||||||||.|:||:.|||:||||||:
Zfish   197 ESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFD 261

  Fly   273 EQPDYMYLRQLFRILFRTLNHQYDYIYDWTMLKQKTHQGQPNPAILLEQLDKDKEKQN 330
            ::|||.|||||||.||......|||::||.|||...::       ..|:.|:::.:::
Zfish   262 DKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGANR-------TAEEADRERRERD 312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CkIalpha	NP_001162737.1	PKc_like	19..284	CDD:304357	187/264 (71%)
CkIalpha	NP_001162737.1	Pkinase_Tyr	23..284	CDD:285015	185/260 (71%)
csnk1db	NP_998415.1	STKc_CK1_delta_epsilon	8..282	CDD:271027	192/273 (70%)
		TyrKc	10..273	CDD:197581	186/262 (71%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	300..409		2/13 (15%)
		Autoinhibitory. /evidence=ECO:0000250	317..341
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54222
OrthoDB	1	1.010	-	-		D1097975at2759
OrthoFinder	1	1.000	-	-		FOG0000297
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100396
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3408
SonicParanoid	1	1.000	-	-		X224
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.760