DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CkIalpha and F59A6.4

DIOPT Version :9

Sequence 1:	NP_001162737.1	Gene:	CkIalpha / 32221	FlyBaseID:	FBgn0015024	Length:	337	Species:	Drosophila melanogaster
Sequence 2:	NP_494922.2	Gene:	F59A6.4 / 173865	WormBaseID:	WBGene00019086	Length:	762	Species:	Caenorhabditis elegans

Alignment Length:	375	Identity:	89/375 - (23%)
Similarity:	159/375 - (42%)	Gaps:	93/375 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 KESRPEIIVG----GKYRVIRKIGSGSFGDIY--------------LGMSIQSGE--------EV 46
            |.::.::|:|    ..::||..:|||.|||:|              |....:.||        ||
Worm   428 KLAKGDVILGVGATDGWKVINLLGSGGFGDVYKVHRESQPITKCYALKTESEEGEKRYLRLKIEV 492

  Fly    47 AIKMESAHARHPQLLYEAKLYRILSGGVGFPRIRHHGKEKNF--------------NTLVMDLLG 97
            .:.|::|..                        :...|.|||              ..:||.|:|
Worm   493 TVMMKTAEK------------------------KKENKFKNFIEFVDRGKCEQLKCKYVVMGLVG 533

  Fly    98 PSLEDL-FNFCTRHFTIKTVLMLVDQMIGRLEYIHLKCFIHRDIKPDNFLMGIGRHCNKLFLIDF 161
            |||||: ..:....|:..|...:..|.:..|:.:|...::||||||.|:.:|:....:.::::||
Worm   534 PSLEDIRRKYLLGSFSKHTSFNVAIQTVTALQDLHSIGYLHRDIKPANYAVGLEDREDTVYMLDF 598

  Fly   162 GLAKKFRDPHTRHHIVYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYV---MMYFNRGVLP 223
            |:||.:.|.:..|.:..::.|.| ||.|||.....:..||.|:||:|:..|:   :|..:.| :|
Worm   599 GIAKLYVDENGEHKVKRKKVKFL-GTLRYACRACMMQQEQGRKDDLETWIYLVFDLMDESHG-MP 661

  Fly   224 WQGMKA-----NTKQQKYEKISEKKMSTPIEVLCKGSPAEFSMYLNYCRSLRFEEQPDYMYLRQL 283
            |:.:.:     .:|.:.:.......:|..::.| ||       .::|..::::|..|||.|:...
Worm   662 WRSLCSPKEILKSKNEFFTNFDSSSVSATLKRL-KG-------LVSYVDNMQYETTPDYDYIINF 718

  Fly   284 FRILFRTLNHQYDYIYDWT-MLKQKTHQGQPNPAILLEQLDKDKEKQNGK 332
            .:........:.....||. .||.|....:.         |:..:|.:|:
Worm   719 LKTTATEAGAKISKKLDWIGKLKNKEFDSES---------DRSDKKASGE 759

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CkIalpha	NP_001162737.1	PKc_like	19..284	CDD:304357	78/309 (25%)
CkIalpha	NP_001162737.1	Pkinase_Tyr	23..284	CDD:285015	77/305 (25%)
F59A6.4	NP_494922.2	PKc_like	120..372	CDD:304357
		SPS1	121..>274	CDD:223589
		SPS1	443..>627	CDD:223589	54/208 (26%)
		PKc_like	444..720	CDD:304357	78/309 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810