DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CkIalpha and T05A7.6

DIOPT Version :9

Sequence 1:	NP_001162737.1	Gene:	CkIalpha / 32221	FlyBaseID:	FBgn0015024	Length:	337	Species:	Drosophila melanogaster
Sequence 2:	NP_494824.1	Gene:	T05A7.6 / 173804	WormBaseID:	WBGene00020223	Length:	758	Species:	Caenorhabditis elegans

Alignment Length:	365	Identity:	92/365 - (25%)
Similarity:	153/365 - (41%)	Gaps:	77/365 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 KESRPEIIVG----GKYRVIRKIGSGSFGDIYL--GMSIQSGEEVAIKMESAHARHPQLLYEAKL 66
            |.|..::|:|    ..::|:..:|||.|||:|.  ..|..|.:..|:|.||.......|..:.::
Worm   424 KLSSGDVILGVGATDGWKVVNLLGSGGFGDVYKVHRESQASNKCYALKTESEEGEKRYLRLKVEV 488

  Fly    67 YRILSGGVGFPRIRHHGKEKNF--------------NTLVMDLLGPSLEDL-FNFCTRHFTIKTV 116
            ..::...    ..:...|.|||              ..:||.|:||||||: ..:....|:..|.
Worm   489 TVMMKTA----EKKKDNKFKNFIEFVDRGKCEQLKCKFVVMGLVGPSLEDIRRKYLLASFSKHTS 549

  Fly   117 LMLVDQMIGRLEYIHLKCFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKFRDPHTRHHIVYRED 181
            ..:..|.:..|..:|...::||||||.|:.:|:....:.::::|||:||.:.|.:..|.|..::.
Worm   550 FNVAIQTVTALRDLHSLGYLHRDIKPANYAVGLDEREDTVYMLDFGIAKLYVDENGVHKIKRKKV 614

  Fly   182 KNLTGTARYASINAHLGIEQSRRDDMESLGYV---MMYFNRGVLPWQGMKANTKQQKYEKISEKK 243
            |.| ||.|||.....:..||.|:||:|:..|:   :|....| :||                 :.
Worm   615 KFL-GTLRYACRACMMQQEQGRKDDLETWIYLVFDLMDEAHG-MPW-----------------RA 660

  Fly   244 MSTPIEVLCKGSPAEFSMYLN---------------YCRSLRFEEQPDYMYLRQLFRILFRTLNH 293
            :..|.|:| |.....|:.:.|               |...::::..|||.|:....:.....:..
Worm   661 LCDPREIL-KSKNTFFATFDNFQFSNILKRLKDLVVYVDDMQYDTTPDYSYILNFLKTTANDVGA 724

  Fly   294 QYDYIYDWT-MLKQKTHQGQPNPAILLEQLDKDKEKQNGK 332
            :.....||. .||||             :.|.:.||...|
Worm   725 KITKKLDWMGKLKQK-------------EFDSESEKSEKK 751

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CkIalpha	NP_001162737.1	PKc_like	19..284	CDD:304357	78/299 (26%)
CkIalpha	NP_001162737.1	Pkinase_Tyr	23..284	CDD:285015	77/295 (26%)
T05A7.6	NP_494824.1	SPS1	100..>321	CDD:223589
		PKc_like	116..368	CDD:304357
		SPS1	439..>623	CDD:223589	54/188 (29%)
		PKc_like	440..716	CDD:304357	78/299 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810