DRSC/TRiP Functional Genomics Resources

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Protein Alignment CkIalpha and Ttbk1

DIOPT Version :9

Sequence 1:NP_001162737.1 Gene:CkIalpha / 32221 FlyBaseID:FBgn0015024 Length:337 Species:Drosophila melanogaster
Sequence 2:NP_001156336.1 Gene:Ttbk1 / 106763 MGIID:2147036 Length:1308 Species:Mus musculus


Alignment Length:364 Identity:113/364 - (31%)
Similarity:173/364 - (47%) Gaps:61/364 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 IVGGKYRVIRKIGSGSFGDIYLGMSIQSGEEVAIKMESAHARHPQLLYEAKLYRILSGGVGFPRI 79
            :|..:::|::|||.|.||:||..|.:.:.|.||:|:|||......|..|..:.:.|.|.....|.
Mouse    29 VVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHVCRF 93

  Fly    80 RHHGKEKNFNTLVMDLLGPSLEDLFNFCTR-HFTIKTVLMLVDQMIGRLEYIHLKCFIHRDIKPD 143
            ...|:.:.||.:||.|.|.:|.||.....| .||:.|.|.|..|::..:|.||...|:||||||.
Mouse    94 IGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHSVGFLHRDIKPS 158

  Fly   144 NFLMG-IGRHCNKLFLIDFGLAKKF-------RDPHTRHHIVYREDKNLTGTARYASINAHLGIE 200
            ||.|| :.....|.:::|||||:::       |.|        |......||.||||:|||...|
Mouse   159 NFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPP--------RNVAGFRGTVRYASVNAHKNRE 215

  Fly   201 QSRRDDMESLGYVMMYFNRGVLPWQGMKANTK----QQKYEKISEKKMSTPIEVLCKGSPAEFSM 261
            ..|.||:.||.|:::.|..|.|||:.:|...:    ::|||.          .:|.|..|:||.:
Mouse   216 MGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEKYEH----------RMLLKHMPSEFHL 270

  Fly   262 YLNYCRSLRFEEQPDYMYLRQLFRILFRTLNHQYDYIYDW--------------TMLKQKTHQG- 311
            :|::..||.:..:|||..:..:|....:......:..:||              |..:|.|.|. 
Mouse   271 FLDHIASLDYFTKPDYQLIMSVFENSMKERGIAENEAFDWEKAGTDALLSTSTSTPPQQNTRQTA 335

  Fly   312 --------QPNPAILLEQLDKD-------KEKQNGKPLI 335
                    .|.|..||.:..:|       .:::|..|::
Mouse   336 AMFGVVNVTPVPGDLLRENTEDVLQGEHLSDQENAPPIL 374

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CkIalphaNP_001162737.1 PKc_like 19..284 CDD:304357 98/277 (35%)
Pkinase_Tyr 23..284 CDD:285015 97/273 (36%)
Ttbk1NP_001156336.1 STKc_TTBK1 33..294 CDD:271032 98/278 (35%)
PHA03307 324..>683 CDD:223039 11/51 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 364..397 2/11 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 418..448
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 474..671
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 720..899
PHA03307 963..>1305 CDD:223039
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 985..1085
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1097..1308
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1164
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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