DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tomosyn and SRO7

DIOPT Version :9

Sequence 1:NP_001162735.1 Gene:Tomosyn / 32217 FlyBaseID:FBgn0030412 Length:1470 Species:Drosophila melanogaster
Sequence 2:NP_015357.1 Gene:SRO7 / 856144 SGDID:S000006236 Length:1033 Species:Saccharomyces cerevisiae


Alignment Length:719 Identity:160/719 - (22%)
Similarity:265/719 - (36%) Gaps:194/719 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    37 FTLKKTFRHGFPYSPTSFAFDPVQKLLAIGDKSGYIRILGRPGVDAHAKHEGESECAVLFAQFLV 101
            |:|.:|.::|....|.:.|||..|.||||...:|.:.|.|:..|:...|.|..|  |:...:|: 
Yeast    66 FSLAETNKYGMSSKPIAAAFDFTQNLLAIATVTGEVHIYGQQQVEVVIKLEDRS--AIKEMRFV- 127

  Fly   102 NEGA-LVTVTADDTIHLWSI-RQKTPRIVQSLKFQRERVTCIHLPVGSKWLYVGTEKGNIHVVHI 164
             :|. ||.:.|.||:::.|: .||    |.:..|...::|.|.......|:.:|.:.|::.|..|
Yeast   128 -KGIYLVVINAKDTVYVLSLYSQK----VLTTVFVPGKITSIDTDASLDWMLIGLQNGSMIVYDI 187

  Fly   165 DTFALSGY-IINWNKAIEVVRTSHPGA----VIALCDNPLDANKLLIAFECGLLVL--------- 215
            |...||.: :.|..|:     :..|.|    ::::..||.|...:||::|...|..         
Yeast   188 DRDQLSSFKLDNLQKS-----SFFPAARLSPIVSIQWNPRDIGTVLISYEYVTLTYSLVENEIKQ 247

  Fly   216 ------------WDLKAKCAELRWQAAEAVKSLAWHYEGKYFVSSHTDGSICSWPTKPQAKPQSQ 268
                        .|...|..|.|  ..:.::|| :|....:.::.|.|.|:..|.........::
Yeast   248 SFIYELPPFAPGGDFSEKTNEKR--TPKVIQSL-YHPNSLHIITIHEDNSLVFWDANSGHMIMAR 309

  Fly   269 VCPHAKIN-------KDG--NAEKCKPIY------------KVDLKSSATG--ETFTIFSGG--- 307
            .....:||       :|.  ||.|...:|            .:..||.:.|  ::.|:...|   
Yeast   310 TVFETEINVPQPDYIRDSSTNAAKISKVYWMCENNPEYTSLLISHKSISRGDNQSLTMIDLGYTP 374

  Fly   308 ---MPSEKGSK---SNCITVMVGKATTVLEMEHAVCDFITLCENPWPCETQEPY-------AIAV 359
               :.|.:|.|   :|...:.:....|.:.:           .|..|...|.||       .:.:
Yeast   375 RYSITSYEGMKNYYANPKQMKIFPLPTNVPI-----------VNILPIPRQSPYFAGCHNPGLIL 428

  Fly   360 LLQYDLVLIDLLTPG--FPCFESPYPMDLH-ESPVTCCTYLTDCPSDLVPAFYSVGRTTTSKKSC 421
            |:..:..:..:|.|.  |....|.:|.:|. ..|:...:.....|:.|          .....|.
Yeast   429 LILGNGEIETMLYPSGIFTDKASLFPQNLSWLRPLATTSMAASVPNKL----------WLGALSA 483

  Fly   422 FSEREWPISGG-----EWSPASCSYSEIVITGHQDGSLKFWDSGAGTLQ--ILYKLKTAKMFEKP 479
            ...:::.:.||     :..||  .|....||||.:||::.:|:..|.:|  ..:::..::...|.
Yeast   484 AQNKDYLLKGGVRTKRQKLPA--EYGTAFITGHSNGSVRIYDASHGDIQDNASFEVNLSRTLNKA 546

  Fly   480 RSHVAHSHPESDNPLAVHLIFLCSESRRLCVAGAMGQVMLFK-----FRKVESTSEVLVLEIPIL 539
            :.            |||..|...:|:..|.|:...|.|:|||     |..||:..|...||:.  
Yeast   547 KE------------LAVDKISFAAETLELAVSIETGDVVLFKYEVNQFYSVENRPESGDLEMN-- 597

  Fly   540 YENFD---------DIYGTSPECDFLTGHQVQKAESSDSDKT---------------AECSLKV- 579
            :..|.         |:...:| .....|.....|..::..||               |..||.: 
Yeast   598 FRRFSLNNTNGVLVDVRDRAP-TGVRQGFMPSTAVHANKGKTSAINNSNIGFVGIAYAAGSLMLI 661

  Fly   580 -RNGAQ-------RKPPGFQSQLVCLTTGPNRRNVQVTSLCIS---SSYG-------LMAYGTEY 626
             |.|..       |:..|.||  .|:|             ||.   ..||       ||..||:.
Yeast   662 DRRGPAIIYMENIREISGAQS--ACVT-------------CIEFVIMEYGDDGYSSILMVCGTDM 711

  Fly   627 GLVI 630
            |.||
Yeast   712 GEVI 715

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TomosynNP_001162735.1 WD40 52..257 CDD:295369 59/232 (25%)
WD40 <55..257 CDD:225201 59/229 (26%)
WD40 repeat 95..133 CDD:293791 11/39 (28%)
WD40 repeat 138..184 CDD:293791 12/46 (26%)
WD40 repeat 192..226 CDD:293791 10/54 (19%)
LLGL 269..375 CDD:285555 25/146 (17%)
R-SNARE_STXBP5_6 1403..1463 CDD:277226
SRO7NP_015357.1 Lgl_C 548..943 CDD:400768 47/198 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C157345885
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1983
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0.861654 Normalized mean entropy S4092
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm46530
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR10241
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2301
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
87.820

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