DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tomosyn and llgl1

DIOPT Version :9

Sequence 1:	NP_001162735.1	Gene:	Tomosyn / 32217	FlyBaseID:	FBgn0030412	Length:	1470	Species:	Drosophila melanogaster
Sequence 2:	XP_005164198.1	Gene:	llgl1 / 751760	ZFINID:	ZDB-GENE-060825-69	Length:	1041	Species:	Danio rerio

Alignment Length:	1037	Identity:	280/1037 - (27%)
Similarity:	429/1037 - (41%)	Gaps:	191/1037 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKKFTFKGVLDGFRQSVQPQATRQEQEIQEQLKADHFTLKKTFRHGFPYSPTSFAFDPVQKLLAI 65
            |.||.|:      ||...|.        :|::|.|.|...||..||||..|::.|:||..:|:||
Zfish     1 MMKFRFR------RQGNDPH--------REKIKQDLFAFNKTVEHGFPNQPSALAYDPKLQLMAI 51

  Fly    66 GDKSGYIRILGRPGVDAHAKHEGESECAVLFAQFLVNEGALVTVTADDTIHLWSIRQKTPRI--- 127
            |.|||.|:|.|.|||:....|  :...||....||..:|.::::..|:|||||.|.|:..|.
Zfish    52 GTKSGAIKIYGAPGVEMTGLH--KDTAAVTQIHFLCGQGRILSLLDDNTIHLWEIVQRENRSHLL 114

  Fly   128 -VQSLKF---------QRERVTCIHLPVGSKWLYVGTEKGNIHVVHIDTFALSGYIINWNKAI-- 180
             |.|...         ...|||.:.|.:....|.:|||.|.:|.:.:.|..|      .||::
Zfish   115 EVHSFNLPGRPGIESTSATRVTVMLLNLSCNLLALGTEGGGVHFLELPTLTL------LNKSLFQ 173

  Fly   181 EVVRTSHP---------GAVIALCDNPLDANKLLIAFECGLLVLWDLKAKCAELRWQAAEAVKSL 236
            :.:..|.|         |.|.:|.::|.|::|:||.:..||:|||||.::..:..:...:.::||
Zfish   174 DEIMQSVPEEYKCGKSLGPVESLQEHPKDSDKILIGYSRGLVVLWDLSSRHVDNLFLGKQQLESL 238

  Fly   237 AWHYEGKYFVSSHTDGSICSWPTKPQAKPQSQVCPHAKINK--DGNAEKCKPIYKVDLKSSATGE 299
            .|...|..|||||:||....|     |...|..|.|..::.  ......||.:.|:..:::.:|.
Zfish   239 VWERSGNSFVSSHSDGGYMVW-----AVSSSNPCTHDPVSSTIPYGPFPCKAVNKILWRTTESGA 298

  Fly   300 TFTIFSGGMPSEKGSKSNCITVMVGKATTVLEMEHAVCDFITLCENPWPCETQEPYAIAVLLQYD 364
            ...:||||||.......:|:|::...:...|:....|.||.|:.......:..||.|:.|||:.:
Zfish   299 PLVLFSGGMPRASYGDRHCLTILQDSSHVTLDFTSRVIDFFTIHCTDTEKDFDEPSALVVLLEEE 363

  Fly   365 LVLIDLLTPGFPCFESPYPMDLHESPVTCCTYLTDCPSDLVPAFYSVGRTTTSKKSC--FSEREW 427
            ||:|||..||:|...:||...||.|.:||..::::.|..|.....|.|     ::.|  .:...|
Zfish   364 LVVIDLQMPGWPTVPAPYLAPLHSSAITCSCHISNVPPKLWERVISAG-----QQQCPLQNYENW 423

  Fly   428 PISGGEWSPASCSYSEIVITGHQDGSLKFWDSGAGTLQILYKLKTAKMFEKPRSH---------- 482
            ||.||:.........|:::|||:||:::|||:...:|:.||||.||.:|:....|
Zfish   424 PICGGKNLAPDPKQKELLLTGHEDGTVRFWDASGVSLKPLYKLSTASIFQTDCEHNDSLTQAGEE 488

  Fly   483 -------VAHSHPESDNP-LAVHLIFLCSESRRLCVAGAMGQVMLFKFRKVESTSEVLVLEIPIL 539
                   |....|.||:| |.:..|.||..|.:|.|||..|||::......:|...:.|..:.:|
Zfish   489 EWPPFRKVGCFDPYSDDPRLGIQKISLCKYSGKLVVAGTAGQVIVMVLGDEKSDHMIDVATVDLL 553

  Fly   540 YENFDDIYGTSPECDFLTGHQVQKAESSDSDKTAECSLKVRNGAQRKPPGFQSQLVCLTTGPNRR 604
            .:.         |.....||.               .|..::|:....||||..::.....|
Zfish   554 QDR---------EGFTWKGHD---------------RLPPKSGSVVFAPGFQPVVLVQCLPP--- 591

  Fly   605 NVQVTSLCISSSYGLMAYGTEYGLVIIDIIQKICLLSVACP----DLYGAHDPYSRTPKSPKRIE 665
             ..||::.:.:.:.|:|:||.:|..:.|..::..:|: .|.    |......|.||.....|.:.
Zfish   592 -AAVTAVTLHAEWNLIAFGTSHGFGLFDYHRRSPVLA-RCTLHPNDSLAMEGPLSRVKSLKKSLR 654

  Fly   666 NKEEQSRSP--SSDQLNDTTSPDSPSLEFVPEAGETSA-HDGVATATSSR--PSSPDPVVNSA-- 723
            ....:.|..  |..:.....||.|.    |.||....| ||...|....|  |.|.|..::..
Zfish   655 QSFRRIRKSRVSGKKRVVVNSPTSK----VQEANAHLADHDAEVTPVQRRIEPRSADDSLSGVVR 715

  Fly   724 ----RETLL---------------SGSAAATAA--------AAASAAVMMAKSPQRDDAAPK--- 758
                .:|.|               |||..|.|.        :..|...::.|..|....||.
Zfish   716 CLCFADTFLRDGTHHGPTMWAGTNSGSVYAYALDVPSQEKFSEQSVEALLGKEIQLMHRAPVVSI 780

  Fly   759 ELQDRRKSMSWKTFNLKRQLSKVNMKIGGLNVNTDMESLKNSSIFYTPKEVSPEAATPPATEE-- 821
            .:.|.|.:...:.:.:.|.|:|.....|..:|.  :.|.:...:|..|| ||.:........|
Zfish   781 AVLDGRGNPLPEPYEVSRDLAKAPDMQGSHSVL--IASEEQFKVFMLPK-VSAKTKFKLTAHEGC 842

  Fly   822 --------EATPEGKEDESLDDGEMATNAGAAAAASPSPAVRGKFRSSTTDSPDEGASSSIASGI 878
                    ..|....||.|.:.....||.|.....| .||:|.:.|.......|   .|.|||.:
Zfish   843 RVRKVALANFTSVSSEDYSENALVCLTNMGDIHMFS-VPALRPQVRYDCVRKED---ISGIASCV 903

  Fly   879 ----------------------RRVDFEQPAGVEVERPNNLPLADAPAPLKPARQKFKEKSR 918
                                  .||..|...||:||||:::....:.:...|.:.....||:
Zfish   904 FTKTGQGFYLISPSEYERFSLSARVITEPLCGVDVERPHDVSAHSSSSTTLPPQANGTHKSQ 965

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tomosyn	NP_001162735.1	WD40	52..257	CDD:295369	75/228 (33%)
		WD40	<55..257	CDD:225201	75/225 (33%)
		WD40 repeat	95..133	CDD:293791	14/41 (34%)
		WD40 repeat	138..184	CDD:293791	13/47 (28%)
		WD40 repeat	192..226	CDD:293791	13/33 (39%)
		LLGL	269..375	CDD:285555	31/107 (29%)
		R-SNARE_STXBP5_6	1403..1463	CDD:277226
llgl1	XP_005164198.1	WD40	<38..264	CDD:225201	77/238 (32%)
		WD40 repeat	78..126	CDD:293791	15/47 (32%)
		WD40 repeat	136..172	CDD:293791	12/41 (29%)
		WD40 repeat	193..234	CDD:293791	14/40 (35%)
		LLGL	275..374	CDD:285555	29/98 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1983
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000702
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X453
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810