DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tomosyn and stxbp5b

DIOPT Version :9

Sequence 1:NP_001162735.1 Gene:Tomosyn / 32217 FlyBaseID:FBgn0030412 Length:1470 Species:Drosophila melanogaster
Sequence 2:XP_009291096.1 Gene:stxbp5b / 571925 ZFINID:ZDB-GENE-090821-5 Length:1186 Species:Danio rerio


Alignment Length:1518 Identity:551/1518 - (36%)
Similarity:782/1518 - (51%) Gaps:394/1518 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MKKFTFKGVLDGF---------RQSVQPQATRQEQEIQEQLKADHFTLKKTFRHGFPYSPTSFAF 56
            ||||..:.||||.         ..:..||:  ....|||.|:::||.|.||.||||||.|:|.||
Zfish    15 MKKFNIRKVLDGLTAASSSSSSAAAASPQS--GNDMIQETLQSEHFQLCKTVRHGFPYQPSSMAF 77

  Fly    57 DPVQKLLAIGDKSGYIRILGRPGVDAHAKHEGESECAVLFAQFLVNEGALVTVTADDTIHLWSIR 121
            |||||:||||.:||.:|:.||.||:.:.:||..|  ||:..:||||.||||:..|||:||||::|
Zfish    78 DPVQKILAIGTQSGALRLFGRAGVECYCQHESGS--AVIQLEFLVNVGALVSALADDSIHLWNLR 140

  Fly   122 QKTPRIVQSLKFQRERVTCIHLPVGSKWLYVGTEKGNIHVVHIDTFALSGYIINWNKAIEVVRTS 186
            ||.|.::.||||.|||:|..|||..|||||||||:||||:|::::|.||||:|.||||||:...:
Zfish   141 QKLPAVLHSLKFNRERITFCHLPFQSKWLYVGTERGNIHIVNVESFTLSGYVIMWNKAIELSSKT 205

  Fly   187 HPGAVIALCDNPLDANKLLIAFECGLLVLWDLKAKCAELRWQAAEAVKSLAWHYEGKYFVSSHTD 251
            |||.|:.:.|||:|..||||.||||::||||||:|.|:.|:...||:.|:|||:|||.||.||:|
Zfish   206 HPGPVVHISDNPMDEGKLLIGFECGIVVLWDLKSKKADYRYNYDEAIHSVAWHHEGKQFVCSHSD 270

  Fly   252 GSICSWPTKPQAKPQSQVCPHAKINKDG-NAEKCKPIYKVDLKSSATGETFTIFSGGMPSEKGSK 315
            |::.:|..:..|||...:.||.|..||| ..|.||||.||:.|::..|:.|.|..||:..:...:
Zfish   271 GTLTTWNVRAPAKPAQIITPHGKQPKDGKKPEPCKPILKVEYKTTRAGDPFMILCGGLSYDTVGR 335

  Fly   316 SNCITVMVGKATTVLEMEHAVCDFITLCENPWPCETQEPYAIAVLLQYDLVLIDLLTPGFPCFES 380
            ..|:|||.||:|.||||::.:.||:||||.|:|.:.|||||:.|||:.|||:|||...|:|.||:
Zfish   336 RACLTVMHGKSTAVLEMDYPIVDFLTLCETPYPNDFQEPYAVVVLLEKDLVVIDLAQIGYPIFEN 400

  Fly   381 PYPMDLHESPVTCCTYLTDCPSDLVPAFYSVGRTTTSKKSCFSEREWPISGGEWSPASCSYSEIV 445
            |||:.:||||||||.|..|||::.:||.||||  :..|:..||::|||||.|.|...:.|:|||:
Zfish   401 PYPLSIHESPVTCCEYFADCPAEAIPALYSVG--SRQKRQGFSKKEWPISAGNWGQGTLSFSEII 463

  Fly   446 ITGHQDGSLKFWDSGAGTLQILYKLKTAKMFEKPRSHVAHSHPE--SDNPLAVHLIFLCSESRRL 508
            ||||.|||:||||:.|..||:||||||||:|:||||....|..:  .::|.|:.::..|.|||.|
Zfish   464 ITGHADGSIKFWDASALMLQVLYKLKTAKVFDKPRSKEEKSSTDIVDEDPFAIQMLSWCPESRVL 528

  Fly   509 CVAGAMGQVMLFKFRKVESTSEVL-VLEIPILYENFDDIY---------------GT--SPECDF 555
            ||||....|::::|.|.|.|:||: :||:.:..| .:::.               ||  ||:...
Zfish   529 CVAGVSAHVIVYRFSKQEVTTEVVQLLEVRMQCE-LNEVESPEGGGDQASAVSTPGTAPSPQTSL 592

  Fly   556 LTGHQVQKAESS-DSDKTAECSLKVRNGAQRKPPGFQ----SQLVCLTTGPNRRNVQVTSLCISS 615
            ...|....:.:| |..:.....||||:...::.||:.    .|||.::..|.:   |:|||.|:|
Zfish   593 PQSHPSTSSNNSCDGLRDNVPCLKVRSSPLKQFPGYHVELLIQLVWVSGEPPQ---QITSLAINS 654

  Fly   616 SYGLMAYGTEYGLVIIDIIQKICLLSVACPDLYGAHDPYSRTPKSPKRIENKEEQSRSPSSDQLN 680
            :|||:|:|...||.::|.|||..||:|...:|||:.||:.|.|:||::       :|.||:|.|:
Zfish   655 AYGLVAFGNGNGLAVVDYIQKTLLLNVTTAELYGSTDPHHRQPRSPRK-------TRQPSADTLH 712

  Fly   681 DTTSPDSPSLEFVPEAGETSAHDGVATATSSRPSSPDPVVNSARETLLSGSAAATAAAAASAAVM 745
                                                       :::.:||.:             
Zfish   713 -------------------------------------------KKSCMSGLS------------- 721

  Fly   746 MAKSPQRDDAAPKELQDRRKSMSWKTFNLKRQLSKVNMKIGGLNVNTDMESLKNSSIFYTPKEVS 810
                                                         |...||:|.....|.     
Zfish   722 ---------------------------------------------NFYSESVKKLRSSYL----- 736

  Fly   811 PEAATPPATEEEATPEGKEDESLDDGEMATNAGAAAAASPSPAVRGKFRSSTTDSPDEGASSSIA 875
                                 ||.||.         .||.:|..|.|       ||..|:.|...
Zfish   737 ---------------------SLCDGN---------DASAAPEERCK-------SPTSGSGSPCN 764

  Fly   876 SGIRRVDFEQPAGVEVERPNNLPLADAPAPLKPARQKFKE--KSRDQRLLSVPNIKYQPRDSRGG 938
            |.                             :.::|||.|  |::.:|:                
Zfish   765 SD-----------------------------EDSKQKFIERVKTKSKRI---------------- 784

  Fly   939 ARNLKNDVSPLMGGGGGGGGVVGASSGIGGSVAGGKKIHKL--------DGTFSRSRSSSMSSID 995
            ::.:.||.:.:                       .:||:.|        |.:||||||||::|||
Zfish   785 SKTVANDFAKI-----------------------SRKINMLADQKDDARDNSFSRSRSSSVTSID 826

  Fly   996 MSSSESVTCLAFIESYAKRNDILTLVPTLWIGTSFGSILTLFITMPER-DVRKSQPVLITINGGP 1059
            ..|.|.::...|.:|.:|:::.|. ||:||:|||.||:|.:.:|:|.. :.|..|||.::..|. 
Zfish   827 RESREVISSFYFCDSLSKKSETLA-VPSLWVGTSLGSMLAIALTVPSTPEQRMQQPVGVSFCGS- 889

  Fly  1060 VVRLKGSITSMSFLDSYGSIIPYTFETWRDEKRDNKDRTPTKSSSRTSPTFTPTTANTLSNTSVA 1124
            ||||||:|..|:.||:.|:::|:.:|.|.:.....::|   :...|..||..|::...       
Zfish   890 VVRLKGAILRMAQLDASGTVLPHIYEPWYEPNAPEEER---ERPRRRRPTSPPSSQEN------- 944

  Fly  1125 GGASAGGGAGGGGGAGGGAASGGAAAGGPAGGGAGAGSAAGAAGGVGSGVTSGGGMSSSSASSSG 1189
                                                                             
Zfish   945 ----------------------------------------------------------------- 944

  Fly  1190 ISGSVSTGLETLTDRQYIVIASEKQTKVFDVANQCCINRIQLSEMDFAVKAETITMKDGSCLATY 1254
                        .|.||.|:.||||.||..:.:|.||....::|..|.::|:.:||..|..:|.:
Zfish   945 ------------QDCQYAVVCSEKQAKVVALPSQHCIFEHNITEASFVLRADVVTMTAGVAIACF 997

  Fly  1255 LSNGHLMVHSLPSLKLLLDTDFLPLMELSFQTKCKQGIVDPMLSIWGQQIIVHEDTTQISKIFCF 1319
            .:|||:|..|||||:.|||.::|||.::                             :|::.|||
Zfish   998 CANGHIMTLSLPSLRPLLDVNYLPLTDM-----------------------------RIARTFCF 1033

  Fly  1320 SHKGHGLYMASPTEIQKFTISSEFCQFILEMMGELYTVHEMPEQPKEGFFKGLFGGGAKLLDREE 1384
            |::|..||:.||||||:.|.|.|.|:.:.||:||::|:.|.||.|..|||||||||||:.||||:
Zfish  1034 SNQGQALYLTSPTEIQRITYSQETCENLQEMLGEMFTLVETPEAPNRGFFKGLFGGGAQSLDRED 1098

  Fly  1385 LFGE-QSGKPNRSVARHIPGP-NLEQLGQRASTAASEISRAHQLAMERGEKLNLLEERAERMANT 1447
            |||| .:||.:||:|:||||| .:|.:...||....|::||.....|||:||..||||...|..:
Zfish  1099 LFGEVAAGKASRSLAQHIPGPGGMEGMKGAASGVVGELARARIALDERGQKLGELEERTAAMMAS 1163

  Fly  1448 AQDFSGTAHQLMLKYKDKKWYQL 1470
            |..||..||.:||||||||||||
Zfish  1164 ADSFSKHAHDMMLKYKDKKWYQL 1186

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TomosynNP_001162735.1 WD40 52..257 CDD:295369 120/204 (59%)
WD40 <55..257 CDD:225201 119/201 (59%)
WD40 repeat 95..133 CDD:293791 21/37 (57%)
WD40 repeat 138..184 CDD:293791 30/45 (67%)
WD40 repeat 192..226 CDD:293791 20/33 (61%)
LLGL 269..375 CDD:285555 52/106 (49%)
R-SNARE_STXBP5_6 1403..1463 CDD:277226 26/60 (43%)
stxbp5bXP_009291096.1 WD40 <58..279 CDD:225201 132/222 (59%)
WD40 73..>280 CDD:295369 121/208 (58%)
WD40 repeat 73..106 CDD:293791 19/32 (59%)
WD40 repeat 114..152 CDD:293791 21/37 (57%)
WD40 repeat 157..203 CDD:293791 30/45 (67%)
WD40 repeat 211..247 CDD:293791 21/35 (60%)
WD40 repeat 252..284 CDD:293791 15/31 (48%)
LLGL 288..395 CDD:285555 52/106 (49%)
R-SNARE_STXBP5 1119..1179 CDD:277246 25/59 (42%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170594295
Domainoid 1 1.000 313 1.000 Domainoid score I1272
eggNOG 1 0.900 - - E1_KOG1983
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 937 1.000 Inparanoid score I338
OMA 1 1.010 - - QHG49198
OrthoDB 1 1.010 - - D53111at33208
OrthoFinder 1 1.000 - - FOG0000702
OrthoInspector 1 1.000 - - otm26250
orthoMCL 1 0.900 - - OOG6_104979
Panther 1 1.100 - - O PTHR10241
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2301
SonicParanoid 1 1.000 - - X453
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
1615.800

Return to query results.
Submit another query.