DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tomosyn and llgl2

DIOPT Version :9

Sequence 1:	NP_001162735.1	Gene:	Tomosyn / 32217	FlyBaseID:	FBgn0030412	Length:	1470	Species:	Drosophila melanogaster
Sequence 2:	NP_001015691.1	Gene:	llgl2 / 548396	XenbaseID:	XB-GENE-868478	Length:	1019	Species:	Xenopus tropicalis

Alignment Length:	1158	Identity:	283/1158 - (24%)
Similarity:	442/1158 - (38%)	Gaps:	311/1158 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKKFTFKGVLDGFRQSVQPQATRQEQEIQEQLKADHFTLKKTFRHGFPYSPTSFAFDPVQKLLAI 65
            ||:|...|                ...::|:||.|.|...||..||||:.|::..:.....|:||
Frog     1 MKRFLRSG----------------HDSVRERLKRDLFQFNKTVEHGFPHQPSALGYSDCLSLMAI 49

  Fly    66 GDKSGYIRILGRPGVDAHAKHEGESECAVLFAQFLVNEGALVTVTADDTIHLWSIRQKTPRIVQS 130
            |.:||.:::.|.|||:....|:..:  :|....|:.::..||||..|:::||||.    |.....
Frog    50 GTRSGALKVYGSPGVEFMGLHDENN--SVTKISFIPDQCQLVTVLDDNSLHLWSF----PHHDGV 108

  Fly   131 LKFQRERVTCIHLPVGS----------------KWLYVGTEKGNIHVVHIDTFALSGYIINWNKA 179
            .:.|.|:...:..|.||                :.||||||.|::.::.:.:.          :.
Frog   109 SELQEEKKFTLRGPPGSPPSVTQIKVLLPHSSGEKLYVGTEGGSVFILELPSL----------RV 163

  Fly   180 IEVVRTSHPGA----------------VIALCDNPLDANKLLIAFECGLLVLWDLKAKCAELRWQ 228
            :|.....|..|                |.||.:||.:.::|||.:..|::|.|||....:...:.
Frog   164 LEEKTVGHEAALQGLPDEYSSRRAFESVEALQENPRNPDQLLIGYSRGMMVTWDLVKGRSVQYFL 228

  Fly   229 AAEAVKSLAWHYEGKYFVSSHTDGSICSWPTK---PQAKPQSQVCPHAKINKDGNAEKCKPIYKV 290
            ..:.::::.|..:||..||.|:||....|...   .|..|:....|:...       :||.|.|:
Frog   229 GKQQLENVFWCRDGKQIVSCHSDGGYNQWEVSNELVQVSPKESKVPYGPF-------RCKAISKI 286

  Fly   291 DLKSSATGET-FTIFSGGMPSEKGSKSNCITVMVGKATTVLEMEHAVCDFITLCENPWP-CETQE 353
            ...::....: :.:|.||||.......:.|:|:.|...|..:....:.|.:.:. ||.| .|..:
Frog   287 TWHTTRRSRSPYVVFQGGMPMASYGDRHIISVVHGNQQTAFDFTSRIIDHVVIA-NPDPSAEYDD 350

  Fly   354 PYAIAVLLQYDLVLIDLLTPGFPCFESPYPMDLHESPVTCCTYLTDCPSDLVPAFYSVGRTTTSK 418
            |.|:.||::.:||:|||.:||:|..:.||.:.||.|.:||..:::..|..|.....|.||...::
Frog   351 PRALLVLVEEELVMIDLQSPGWPVIQCPYLISLHCSAITCSHHISSIPLKLWERIISAGRKQNTQ 415

  Fly   419 KSCFSEREWPISGG-EWSPASCSYSEIVITGHQDGSLKFWDSGAGTLQILYKLKTAKMFEKPRSH 482
               :|...|||.|| ..:||... .::::|||:||:::|||:....||::||:.|..:|:....|
Frog   416 ---YSNMPWPIDGGVNLAPAPFQ-RDLLLTGHEDGTVRFWDASGICLQLMYKMSTVSVFQTESDH 476

  Fly   483 -----------------VAHSHPESDNP-LAVHLIFLCSESRRLCVAGAMGQVMLFKFRKVESTS 529
                             |....|.||:| |.:..|::|..|..|.|||..|||::.:..  :..:
Frog   477 NDNVNSNEEEEWPPLRKVGSFDPYSDDPRLGIQKIYMCKYSGYLSVAGTAGQVLVMELN--DEAA 539

  Fly   530 EVLVLE--IPILYENFDDIYGTSPECDFLTGHQVQKAESSDSDKTAECSLKVRNGAQRKPPGFQS 592
            |.:|.|  :.:|.|.         |.....||:               .|..|....|.|||||.
Frog   540 EHVVDETLVDLLQEQ---------EGYRWKGHK---------------RLHAREDPVRFPPGFQP 580

  Fly   593 QLVCLTTGPNRRNVQVTSLCISSSYGLMAYGTEYGLVIIDIIQK-----ICLLSVACPDLYGAHD 652
            ..:.....|    ..||||.:.|.:.|:|:||.:|..:.|..||     .|.|..:  |......
Frog   581 FALVQCQPP----AAVTSLALHSEWRLLAFGTSHGFGLYDFQQKRQVMAKCTLHAS--DQMALEG 639

  Fly   653 PYSRTP-------KSPKRIENKEEQSRSPSSDQLNDTTS----PDSPSLEFVP-----EAGETSA 701
            |.||..       :|.:||...:...|.|..|::.:..:    .....:|..|     ||  .||
Frog   640 PLSRVKSLKKSLRQSFRRIRRSQVNKRRPGPDRVQEANARFEQEALQEMELAPVQRRIEA--RSA 702

  Fly   702 HDGVATATSSRPSSPDPVVNSARET--LLSGSAAATAAAAA------------SAAVMMAKSPQR 752
            .|.......:...:...:.:|:|.|  |.:|:...|..|.:            :.|...||..|.
Frog   703 EDSFTGFVRTLYFADTYLRDSSRHTPSLWAGTNGGTVYAFSLRVPPTERRMEEAVAATQAKEIQL 767

  Fly   753 DDAAP------------------KELQDRRKS--------------MSWKTFNLKRQLSKVNMKI 785
            ...||                  :...|..||              ..:|.|.|.:..||:.:|:
Frog   768 MHRAPVVGILVLDGHSVPLPEPLEAAHDLSKSPDMQGSHQLLVTSEEQFKVFTLPKVSSKLKLKL 832

  Fly   786 GGLNVNTDMESLKNSSIFYTPKEVSPEAATPPATEEEATPEGKEDESLDDGEMATNAGAAAAASP 850
                ..||...::..::               .|......|...:..|   .:.||.|.....|
Frog   833 ----TATDGCRVRKMTV---------------CTYGSCKSEEHSENHL---TILTNLGDIQVVS- 874

  Fly   851 SPAVRGKFRSSTTDSPDEGASSSIASGIRRVDF-EQPAGVEVERPNNL------------PLA-- 900
            .|.::.:.|.......|       .|||....| :..|||....|:.|            |.|
Frog   875 LPHLKPQVRYDCIRKED-------VSGIASCVFTKHGAGVLSNLPSELERFSLSTCWLVAPRARV 932

  Fly   901 DAPAPLKPARQKFKEKSRDQRLLSVPNIKYQPRDS---RGGARNLKNDVSPLMGGGGGGGGVVGA 962
            |.|.|                          ||:|   |||:.:...|.|              .
Frog   933 DPPEP--------------------------PRNSRLRRGGSTDQPTDRS--------------R 957

  Fly   963 SSG---IGGSVAGG--------------KKIHK-LDGTFSRSRSSSMSSIDMS 997
            |||   .||..|.|              |:|.. |:||  |...|..||..||
Frog   958 SSGTDHTGGQRAQGTLMEHALLNDEKMLKEIQSTLEGT--RISYSERSSRQMS 1008

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tomosyn	NP_001162735.1	WD40	52..257	CDD:295369	59/236 (25%)
		WD40	<55..257	CDD:225201	59/233 (25%)
		WD40 repeat	95..133	CDD:293791	11/37 (30%)
		WD40 repeat	138..184	CDD:293791	11/61 (18%)
		WD40 repeat	192..226	CDD:293791	12/33 (36%)
		LLGL	269..375	CDD:285555	29/107 (27%)
		R-SNARE_STXBP5_6	1403..1463	CDD:277226
llgl2	NP_001015691.1	WD40 repeat	36..72	CDD:293791	11/35 (31%)
		WD40	<40..266	CDD:295369	60/241 (25%)
		WD40	<41..264	CDD:225201	60/238 (25%)
		WD40 repeat	77..124	CDD:293791	14/50 (28%)
		WD40 repeat	129..176	CDD:293791	10/56 (18%)
		WD40 repeat	189..228	CDD:293791	13/38 (34%)
		LLGL	272..372	CDD:285555	29/107 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000702
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X453
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910