DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tomosyn and Llgl1

DIOPT Version :10

Sequence 1:NP_727628.3 Gene:Tomosyn / 32217 FlyBaseID:FBgn0030412 Length:1470 Species:Drosophila melanogaster
Sequence 2:NP_001291542.1 Gene:Llgl1 / 54265 RGDID:3012 Length:1067 Species:Rattus norvegicus


Alignment Length:1547 Identity:324/1547 - (20%)
Similarity:523/1547 - (33%) Gaps:566/1547 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MKKFTFKGVLDGFRQSVQPQATRQEQEIQEQLKADHFTLKKTFRHGFPYSPTSFAFDPVQKLLAI 65
            |.||.|:      ||...||        :|:||.:.|...||..||||..|::.||||..:::||
  Rat     1 MMKFRFR------RQGADPQ--------REKLKQELFAFHKTVEHGFPNQPSALAFDPELRIMAI 51

  Fly    66 GDKSGYIRILGRPGVDAHAKHEGESECAVLFAQFLVNEGALVTVTADDTIHLWSIRQKT--PRIV 128
            |.:||.::|.|.|||:....|  .....|....||..:|.|:|:..|.::|||.|.|:.  ..:.
  Rat    52 GTRSGAVKIYGAPGVEFTGLH--RDAATVTQMHFLPGQGRLLTLLDDSSLHLWEIIQRNGCAHLE 114

  Fly   129 QSLKFQ---------------RERVTCIHLPVGSKWLYVGTEKGNIHVVHIDTFA-LSGYIINWN 177
            :.|.|.               ..|||.:.|..|.. :.:|||.|:|..:.:.|.| |.|..::.:
  Rat   115 EGLSFHPPSRPSFDNASFPAGLTRVTVVLLAAGDT-VVLGTESGSIFFLDVATLALLEGQTLSPD 178

  Fly   178 KAIEVVRTSHP-----GAVIALCDNPLDANKLLIAFECGLLVLWDLKAKCAELRWQAAEAVKSLA 237
            :.:..|...:.     |.|.:|..:..|.:|:||.:..||||:|....:..|..:...:.::||.
  Rat   179 EVLRSVPDDYRCGKALGPVESLQGHLQDPSKILIGYSRGLLVIWSQATQSVEHVFLGNQQLESLC 243

  Fly   238 WHYEGKYFVSSHTDGSICSWPT----KPQAKPQSQVCPHAKINKDGNAEKCKPIYKVDLKSSATG 298
            |...|...:|||:|||...|.|    .|..:|.....|:...       .||.|.|:..:|..:|
  Rat   244 WGRGGSNIISSHSDGSYAIWSTDTGSPPTLQPTVVTTPYGPF-------PCKAINKILWRSCESG 301

  Fly   299 ETFTIFSGGMPSEKGSKSNCITVMVGKATTVLEMEHAVCDFITLCENPWPCETQEPYAIAVLLQY 363
            :.|.|||||||.......:|::|:..:....|:....|.||.|:...........|.|:||||:.
  Rat   302 DHFIIFSGGMPRASYGDRHCVSVLRAETLVTLDFTSRVIDFFTVHSTQPEDGFDNPQALAVLLEE 366

  Fly   364 DLVLIDLLTPGFPCFESPYPMDLHESPVTCCTYLTDCPSDLVPAFYSVGRTTTSKKSCFSEREWP 428
            :||::||.|||:|...:||...||.|.:||..::.:.||.|.....|.|. ..|.:...|...||
  Rat   367 ELVVLDLQTPGWPAVPAPYLAPLHSSAITCSAHVANVPSKLWARIVSAGE-RQSPQPASSALSWP 430

  Fly   429 ISGGEWSPASCSYSEIVITGHQDGSLKFWDSGAGTLQILYKLKTAKMFEKPRSH----------- 482
            |:||.......|...:::|||:||:::|||:....|:.||||.||.:|:....|           
  Rat   431 ITGGRNLAQEPSQRGLLLTGHEDGTVRFWDASGVALRPLYKLSTAGLFQTDCEHADSLAQAVEDD 495

  Fly   483 ------VAHSHPESDNP-LAVHLIFLCSESRRLCVAGAMGQVMLFKFRKVESTSEVLVLEIPILY 540
                  |....|.||:| |.:..:.||..:.::.|||..|||::.:...|.....|.|..:.:|.
  Rat   496 WPPFRKVGCFDPYSDDPRLGIQKVALCKYTAQMVVAGTAGQVLVLELSDVPGEHTVSVASVDLLQ 560

  Fly   541 ENFDDIYGTSPECDFLTGHQVQKAESSDSDKTAECSLKVRNGAQRKPPGFQSQLVCLTTGPNRRN 605
            :.         |.....||:               .|....|....|.|||.:::.....|    
  Rat   561 DR---------EGFTWKGHE---------------RLSPHTGPLPWPAGFQPRVLIQCLPP---- 597

  Fly   606 VQVTSLCISSSYGLMAYGTEYGLVIIDIIQKICLLSVACPDLYGAHDPYSRTPKSPKRIENKEEQ 670
            ..||::.:.:.:.|:|:||.:|..:.|..:|..:|              :|....|         
  Rat   598 AAVTAVALHAEWSLVAFGTSHGFGLFDYQRKSPVL--------------ARCTLHP--------- 639

  Fly   671 SRSPSSDQLNDTTSPDSPSLEFVPEAGETSAHDGVATATSSRPSSPDPVVNSARETLLSGSAAAT 735
                     ||:.:.:.|                     .||       |.|.:::|        
  Rat   640 ---------NDSLAMEGP---------------------LSR-------VKSLKKSL-------- 659

  Fly   736 AAAAASAAVMMAKSPQRDDAAPKELQDRRKSMSWKTFNLKRQLSKVNMKIGGLNVNTDMESLKNS 800
                                        |:|.        |::.|                    
  Rat   660 ----------------------------RQSF--------RRIRK-------------------- 668

  Fly   801 SIFYTPKEVSPEAATPPATEEEATPEGKEDESLDDGEMATNAGAAAAASPSPAVRGKFRSSTTDS 865
                                                               ..|.||.|::|..|
  Rat   669 ---------------------------------------------------SRVSGKKRATTASS 682

  Fly   866 PDEGASSSIASGIRRVDFEQPAGVEVERPNNLPLADAPAPLKPARQKFKEKSRDQRLLSVPNIKY 930
            ..:.|::.:|        ||....:||             :.|.:::.:.:|.|..|        
  Rat   683 KLQEANAQLA--------EQTCPHDVE-------------MTPVQRRIEPRSADDSL-------- 718

  Fly   931 QPRDSRGGARNLKNDVSPLMGGGGGGGGVVGASSGIGGSVAGGKKIHKLDGTFSRSRSSSMSSID 995
                                             ||:                             
  Rat   719 ---------------------------------SGV----------------------------- 721

  Fly   996 MSSSESVTCLAFIESYAKRNDILTLVPTLWIGTSFGSILTLFITMPER----DVRKSQPVLITIN 1056
                  |.||.|.:::.:  |.....||:|.||:.||:....:.:|..    :.|..|.|...: 
  Rat   722 ------VRCLYFADTFLR--DATHHGPTMWAGTNSGSVFAYALEVPAATAGGEKRPEQAVEAVL- 777

  Fly  1057 GGPVVRL--KGSITSMSFLDSYGSIIPYTFETWRDEKRDNKDRTPTKSSSRTSPTFTPTTANTLS 1119
             |..|:|  :..:.:::.||..|..:|..:|..||.                             
  Rat   778 -GKEVQLMHRAPVVAIAVLDGRGRPLPEPYEASRDL----------------------------- 812

  Fly  1120 NTSVAGGASAGGGAGGGGGAGGGAASGGAAAGGPAGGGAGAGSAAGAAGGVGSGVTSGGGMSSSS 1184
                                        |.|....||.|                          
  Rat   813 ----------------------------AQAPDMQGGHA-------------------------- 823

  Fly  1185 ASSSGISGSVSTGLETLTDRQYIVIASEKQTKVFDV------------ANQ-CCINRIQLSEMDF 1236
                                  ::||||:|.|||.:            |:: |.:.::.|:....
  Rat   824 ----------------------VLIASEEQFKVFTLPKVSAKTKFKLTAHEGCRVRKVALATFAS 866

  Fly  1237 AVK---AETITMKDGSCLATYLSNGHLMVHSLPSLKLLLDTDFLPLMELSFQTKCKQGIVDPMLS 1298
            .:.   |||       |||...:.|.:.|.|:|.|:        |.:..:    |          
  Rat   867 VISEDYAET-------CLACLTNLGDVHVFSVPGLR--------PQVHYA----C---------- 902

  Fly  1299 IWGQQIIVHEDTTQISKIFC-FSHKGHGLYMASPTEIQKFTISSE-----FCQF-ILEMMGELYT 1356
                  |..||.:.|:.  | |:..|.|.|:.||:|.::|::|:.     .|.. |.........
  Rat   903 ------IRKEDISGIAS--CVFTRHGQGFYLISPSEFERFSLSARNITEPLCSLDISWSRNATQP 959

  Fly  1357 VHEMPEQPKEGFFKGLFGGGAKLLDREELFGEQS--GKPNRSVARHIP-GPNLEQLGQRASTAAS 1418
            .|.:.|.||.....|         .|..:...:|  |.|....:.|.. ....|.|....|..:.
  Rat   960 SHRLQESPKLSQANG---------TRNIILAPESCEGSPRSPSSAHSKLADTTEPLEATLSPVSI 1015

  Fly  1419 EISRAHQLAMER---------GEKLNLLEERAERMANTAQDFSGTAHQLMLK 1461
            :.:.:....::.         .:.|...|:..:.:.|...|.:|.|:.|:::
  Rat  1016 DSAASGDTMLDTTGDVTAEYVKDFLGSPEDSEKNLRNLGADDAGRAYTLLIE 1067

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TomosynNP_727628.3 WD40 <41..257 CDD:441893 74/238 (31%)
WD40 repeat 95..133 CDD:293791 12/39 (31%)
WD40 repeat 138..184 CDD:293791 13/46 (28%)
WD40 repeat 192..226 CDD:293791 11/33 (33%)
LLGL 268..376 CDD:462446 35/107 (33%)
R-SNARE_STXBP5_6 1403..1463 CDD:277226 10/68 (15%)
Llgl1NP_001291542.1 WD40 repeat 38..73 CDD:293791 15/36 (42%)
WD 1 38..71 14/32 (44%)
WD 2 78..119 13/40 (33%)
WD40 repeat 116..174 CDD:293791 16/58 (28%)
WD 3 139..175 13/36 (36%)
WD40 repeat 182..234 CDD:293791 14/51 (27%)
WD 4 199..233 11/33 (33%)
WD40 repeat 239..282 CDD:293791 14/42 (33%)
WD 5 239..271 12/31 (39%)
LLGL 278..379 CDD:462446 35/107 (33%)
WD 6 289..331 14/41 (34%)
WD 7 339..373 12/33 (36%)
WD 8 395..473 27/78 (35%)
WD 9 517..592 21/98 (21%)
WD 10 601..662 20/156 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 670..694 8/31 (26%)
WD 11 722..782 17/63 (27%)
WD 12 791..843 20/156 (13%)
WD 13 848..901 15/67 (22%)
WD 14 915..938 8/22 (36%)

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