DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tomosyn and Llgl1

DIOPT Version :9

Sequence 1:NP_001162735.1 Gene:Tomosyn / 32217 FlyBaseID:FBgn0030412 Length:1470 Species:Drosophila melanogaster
Sequence 2:NP_001291542.1 Gene:Llgl1 / 54265 RGDID:3012 Length:1067 Species:Rattus norvegicus


Alignment Length:1547 Identity:324/1547 - (20%)
Similarity:523/1547 - (33%) Gaps:566/1547 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MKKFTFKGVLDGFRQSVQPQATRQEQEIQEQLKADHFTLKKTFRHGFPYSPTSFAFDPVQKLLAI 65
            |.||.|:      ||...||        :|:||.:.|...||..||||..|::.||||..:::||
  Rat     1 MMKFRFR------RQGADPQ--------REKLKQELFAFHKTVEHGFPNQPSALAFDPELRIMAI 51

  Fly    66 GDKSGYIRILGRPGVDAHAKHEGESECAVLFAQFLVNEGALVTVTADDTIHLWSIRQKT--PRIV 128
            |.:||.::|.|.|||:....|  .....|....||..:|.|:|:..|.::|||.|.|:.  ..:.
  Rat    52 GTRSGAVKIYGAPGVEFTGLH--RDAATVTQMHFLPGQGRLLTLLDDSSLHLWEIIQRNGCAHLE 114

  Fly   129 QSLKFQ---------------RERVTCIHLPVGSKWLYVGTEKGNIHVVHIDTFA-LSGYIINWN 177
            :.|.|.               ..|||.:.|..|.. :.:|||.|:|..:.:.|.| |.|..::.:
  Rat   115 EGLSFHPPSRPSFDNASFPAGLTRVTVVLLAAGDT-VVLGTESGSIFFLDVATLALLEGQTLSPD 178

  Fly   178 KAIEVVRTSHP-----GAVIALCDNPLDANKLLIAFECGLLVLWDLKAKCAELRWQAAEAVKSLA 237
            :.:..|...:.     |.|.:|..:..|.:|:||.:..||||:|....:..|..:...:.::||.
  Rat   179 EVLRSVPDDYRCGKALGPVESLQGHLQDPSKILIGYSRGLLVIWSQATQSVEHVFLGNQQLESLC 243

  Fly   238 WHYEGKYFVSSHTDGSICSWPT----KPQAKPQSQVCPHAKINKDGNAEKCKPIYKVDLKSSATG 298
            |...|...:|||:|||...|.|    .|..:|.....|:...       .||.|.|:..:|..:|
  Rat   244 WGRGGSNIISSHSDGSYAIWSTDTGSPPTLQPTVVTTPYGPF-------PCKAINKILWRSCESG 301

  Fly   299 ETFTIFSGGMPSEKGSKSNCITVMVGKATTVLEMEHAVCDFITLCENPWPCETQEPYAIAVLLQY 363
            :.|.|||||||.......:|::|:..:....|:....|.||.|:...........|.|:||||:.
  Rat   302 DHFIIFSGGMPRASYGDRHCVSVLRAETLVTLDFTSRVIDFFTVHSTQPEDGFDNPQALAVLLEE 366

  Fly   364 DLVLIDLLTPGFPCFESPYPMDLHESPVTCCTYLTDCPSDLVPAFYSVGRTTTSKKSCFSEREWP 428
            :||::||.|||:|...:||...||.|.:||..::.:.||.|.....|.|. ..|.:...|...||
  Rat   367 ELVVLDLQTPGWPAVPAPYLAPLHSSAITCSAHVANVPSKLWARIVSAGE-RQSPQPASSALSWP 430

  Fly   429 ISGGEWSPASCSYSEIVITGHQDGSLKFWDSGAGTLQILYKLKTAKMFEKPRSH----------- 482
            |:||.......|...:::|||:||:::|||:....|:.||||.||.:|:....|           
  Rat   431 ITGGRNLAQEPSQRGLLLTGHEDGTVRFWDASGVALRPLYKLSTAGLFQTDCEHADSLAQAVEDD 495

  Fly   483 ------VAHSHPESDNP-LAVHLIFLCSESRRLCVAGAMGQVMLFKFRKVESTSEVLVLEIPILY 540
                  |....|.||:| |.:..:.||..:.::.|||..|||::.:...|.....|.|..:.:|.
  Rat   496 WPPFRKVGCFDPYSDDPRLGIQKVALCKYTAQMVVAGTAGQVLVLELSDVPGEHTVSVASVDLLQ 560

  Fly   541 ENFDDIYGTSPECDFLTGHQVQKAESSDSDKTAECSLKVRNGAQRKPPGFQSQLVCLTTGPNRRN 605
            :.         |.....||:               .|....|....|.|||.:::.....|    
  Rat   561 DR---------EGFTWKGHE---------------RLSPHTGPLPWPAGFQPRVLIQCLPP---- 597

  Fly   606 VQVTSLCISSSYGLMAYGTEYGLVIIDIIQKICLLSVACPDLYGAHDPYSRTPKSPKRIENKEEQ 670
            ..||::.:.:.:.|:|:||.:|..:.|..:|..:|              :|....|         
  Rat   598 AAVTAVALHAEWSLVAFGTSHGFGLFDYQRKSPVL--------------ARCTLHP--------- 639

  Fly   671 SRSPSSDQLNDTTSPDSPSLEFVPEAGETSAHDGVATATSSRPSSPDPVVNSARETLLSGSAAAT 735
                     ||:.:.:.|                     .||       |.|.:::|        
  Rat   640 ---------NDSLAMEGP---------------------LSR-------VKSLKKSL-------- 659

  Fly   736 AAAAASAAVMMAKSPQRDDAAPKELQDRRKSMSWKTFNLKRQLSKVNMKIGGLNVNTDMESLKNS 800
                                        |:|.        |::.|                    
  Rat   660 ----------------------------RQSF--------RRIRK-------------------- 668

  Fly   801 SIFYTPKEVSPEAATPPATEEEATPEGKEDESLDDGEMATNAGAAAAASPSPAVRGKFRSSTTDS 865
                                                               ..|.||.|::|..|
  Rat   669 ---------------------------------------------------SRVSGKKRATTASS 682

  Fly   866 PDEGASSSIASGIRRVDFEQPAGVEVERPNNLPLADAPAPLKPARQKFKEKSRDQRLLSVPNIKY 930
            ..:.|::.:|        ||....:||             :.|.:::.:.:|.|..|        
  Rat   683 KLQEANAQLA--------EQTCPHDVE-------------MTPVQRRIEPRSADDSL-------- 718

  Fly   931 QPRDSRGGARNLKNDVSPLMGGGGGGGGVVGASSGIGGSVAGGKKIHKLDGTFSRSRSSSMSSID 995
                                             ||:                             
  Rat   719 ---------------------------------SGV----------------------------- 721

  Fly   996 MSSSESVTCLAFIESYAKRNDILTLVPTLWIGTSFGSILTLFITMPER----DVRKSQPVLITIN 1056
                  |.||.|.:::.:  |.....||:|.||:.||:....:.:|..    :.|..|.|...: 
  Rat   722 ------VRCLYFADTFLR--DATHHGPTMWAGTNSGSVFAYALEVPAATAGGEKRPEQAVEAVL- 777

  Fly  1057 GGPVVRL--KGSITSMSFLDSYGSIIPYTFETWRDEKRDNKDRTPTKSSSRTSPTFTPTTANTLS 1119
             |..|:|  :..:.:::.||..|..:|..:|..||.                             
  Rat   778 -GKEVQLMHRAPVVAIAVLDGRGRPLPEPYEASRDL----------------------------- 812

  Fly  1120 NTSVAGGASAGGGAGGGGGAGGGAASGGAAAGGPAGGGAGAGSAAGAAGGVGSGVTSGGGMSSSS 1184
                                        |.|....||.|                          
  Rat   813 ----------------------------AQAPDMQGGHA-------------------------- 823

  Fly  1185 ASSSGISGSVSTGLETLTDRQYIVIASEKQTKVFDV------------ANQ-CCINRIQLSEMDF 1236
                                  ::||||:|.|||.:            |:: |.:.::.|:....
  Rat   824 ----------------------VLIASEEQFKVFTLPKVSAKTKFKLTAHEGCRVRKVALATFAS 866

  Fly  1237 AVK---AETITMKDGSCLATYLSNGHLMVHSLPSLKLLLDTDFLPLMELSFQTKCKQGIVDPMLS 1298
            .:.   |||       |||...:.|.:.|.|:|.|:        |.:..:    |          
  Rat   867 VISEDYAET-------CLACLTNLGDVHVFSVPGLR--------PQVHYA----C---------- 902

  Fly  1299 IWGQQIIVHEDTTQISKIFC-FSHKGHGLYMASPTEIQKFTISSE-----FCQF-ILEMMGELYT 1356
                  |..||.:.|:.  | |:..|.|.|:.||:|.::|::|:.     .|.. |.........
  Rat   903 ------IRKEDISGIAS--CVFTRHGQGFYLISPSEFERFSLSARNITEPLCSLDISWSRNATQP 959

  Fly  1357 VHEMPEQPKEGFFKGLFGGGAKLLDREELFGEQS--GKPNRSVARHIP-GPNLEQLGQRASTAAS 1418
            .|.:.|.||.....|         .|..:...:|  |.|....:.|.. ....|.|....|..:.
  Rat   960 SHRLQESPKLSQANG---------TRNIILAPESCEGSPRSPSSAHSKLADTTEPLEATLSPVSI 1015

  Fly  1419 EISRAHQLAMER---------GEKLNLLEERAERMANTAQDFSGTAHQLMLK 1461
            :.:.:....::.         .:.|...|:..:.:.|...|.:|.|:.|:::
  Rat  1016 DSAASGDTMLDTTGDVTAEYVKDFLGSPEDSEKNLRNLGADDAGRAYTLLIE 1067

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TomosynNP_001162735.1 WD40 52..257 CDD:295369 67/227 (30%)
WD40 <55..257 CDD:225201 67/224 (30%)
WD40 repeat 95..133 CDD:293791 12/39 (31%)
WD40 repeat 138..184 CDD:293791 13/46 (28%)
WD40 repeat 192..226 CDD:293791 11/33 (33%)
LLGL 269..375 CDD:285555 34/105 (32%)
R-SNARE_STXBP5_6 1403..1463 CDD:277226 10/68 (15%)
Llgl1NP_001291542.1 WD40 repeat 38..73 CDD:293791 15/36 (42%)
WD 1 38..71 14/32 (44%)
WD 2 78..119 13/40 (33%)
WD40 repeat 116..174 CDD:293791 16/58 (28%)
WD 3 139..175 13/36 (36%)
WD40 repeat 182..234 CDD:293791 14/51 (27%)
WD 4 199..233 11/33 (33%)
WD40 repeat 239..282 CDD:293791 14/42 (33%)
WD 5 239..271 12/31 (39%)
LLGL 279..378 CDD:285555 34/105 (32%)
WD 6 289..331 14/41 (34%)
WD 7 339..373 12/33 (36%)
WD 8 395..473 27/78 (35%)
WD 9 517..592 21/98 (21%)
WD 10 601..662 20/156 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 669..694 8/32 (25%)
WD 11 722..782 17/63 (27%)
WD 12 791..843 20/156 (13%)
WD 13 848..901 15/67 (22%)
WD 14 915..938 8/22 (36%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1983
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000702
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X453
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
54.810

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