DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tomosyn and LLGL1

DIOPT Version :9

Sequence 1:	NP_001162735.1	Gene:	Tomosyn / 32217	FlyBaseID:	FBgn0030412	Length:	1470	Species:	Drosophila melanogaster
Sequence 2:	XP_011522151.1	Gene:	LLGL1 / 3996	HGNCID:	6628	Length:	1105	Species:	Homo sapiens

Alignment Length:	1485	Identity:	314/1485 - (21%)
Similarity:	508/1485 - (34%)	Gaps:	556/1485 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKKFTFKGVLDGFRQSVQPQATRQEQEIQEQLKADHFTLKKTFRHGFPYSPTSFAFDPVQKLLAI 65
            |.||.|:      ||...||        :|:||.:.|...||..||||..|::.||||..:::||
Human     1 MMKFRFR------RQGADPQ--------REKLKQELFAFNKTVEHGFPNQPSALAFDPELRIMAI 51

  Fly    66 GDKSGYIRILGRPGVDAHAKHEGESECAVLFAQFLVNEGALVTVTADDTIHLWSI--RQKTPRIV 128
            |.:||.::|.|.|||:....|  .....|....||..:|.|:::..|.::|||.|  ......:.
Human    52 GTRSGAVKIYGAPGVEFTGLH--RDAATVTQMHFLTGQGRLLSLLDDSSLHLWEIVHHNGCAHLE 114

  Fly   129 QSLKFQ---------------RERVTCIHLPVGSKWLYVGTEKGNIHVVHIDTFA-LSGYIINWN 177
            ::|.||               ..|||.:.|...|....:|||..::..:.:.|.. |.|..:...
Human   115 EALSFQLPSRPGFDGASAPLSLTRVTVVLLVAASDIAALGTEGSSVFFLDVTTLTLLEGQTLAPG 179

  Fly   178 KAIEVVRTSHP-----GAVIALCDNPLDANKLLIAFECGLLVLWDLKAKCAELRWQAAEAVKSLA 237
            :.:..|...:.     |.|.:|..:..|..|:||.:..||||:|:..::|.:..:...:.::||.
Human   180 EVLRSVPDDYRCGKALGPVESLQGHLRDPTKILIGYSRGLLVIWNQASQCVDHIFLGNQQLESLC 244

  Fly   238 WHYEGKYFVSSHTDGSICSWPTK----PQAKPQSQVCPHAKINKDGNAEKCKPIYKVDLKSSATG 298
            |..:....||||:|||...|...    |..:|.....|:...       .||.|.|:..::..:|
Human   245 WGRDSSTVVSSHSDGSYAVWSVDAGSFPTLQPTVATTPYGPF-------PCKAINKILWRNCESG 302

  Fly   299 ETFTIFSGGMPSEKGSKSNCITVMVGKATTVLEMEHAVCDFITLCENPWPCETQEPYAIAVLLQY 363
            ..|.|||||||.......:|::|:..:....|:....:.||.|:.......|..:|.|:||||:.
Human   303 GHFIIFSGGMPRASYGDRHCVSVLRAETLVTLDFTSRIIDFFTVHSTRPEDEFDDPQALAVLLEE 367

  Fly   364 DLVLIDLLTPGFPCFESPYPMDLHESPVTCCTYLTDCPSDLVPAFYSVGRTTTSKKSCFSEREWP 428
            :||::||.|||:|...:||...||.|.:||..::...|:.|.....|.|. ..|.:...|...||
Human   368 ELVVLDLQTPGWPAVPAPYLAPLHSSAITCSAHVASVPAKLWARIVSAGE-QQSPQPVSSALSWP 431

  Fly   429 ISGGEWSPASCSYSEIVITGHQDGSLKFWDSGAGTLQILYKLKTAKMFEKPRSH----------- 482
            |:||.......|...:::|||:||:::|||:....|:.||||.||.:|:....|
Human   432 ITGGRNLAQEPSQRGLLLTGHEDGTVRFWDASGVALRPLYKLSTAGLFQTDCEHADSLAQAAEDD 496

  Fly   483 ------VAHSHPESDNP-LAVHLIFLCSESRRLCVAGAMGQVMLFKFRKVESTSEVLVLEIPILY 540
                  |....|.||:| |.|..:.||..:.::.|||..|||::.:...|.....|.|..|.:|.
Human   497 WPPFRKVGCFDPYSDDPRLGVQKVALCKYTAQMVVAGTAGQVLVLELSDVPVEQAVSVAIIDLLQ 561

  Fly   541 ENFDDIYGTSPECDFLTGHQVQKAESSDSDKTAECSLKVRNGAQRKPPGFQSQLVCLTTGPNRRN 605
            :.         |.....||:               .|..|.|....|.|||.:::.....|
Human   562 DR---------EGFTWKGHE---------------RLSPRTGPLPWPAGFQPRVLVQCLPP---- 598

  Fly   606 VQVTSLCISSSYGLMAYGTEYGLVIIDIIQKICLLSVACPDLYGAHDPYSRTPKSPKRIENKEEQ 670
            ..||::.:.:.:.|:|:||.:|..:.|..:|..:|              :|....|
Human   599 AAVTAVTLHTEWSLVAFGTSHGFGLFDYQRKSPVL--------------ARCTLHP--------- 640

  Fly   671 SRSPSSDQLNDTTSPDSPSLEFVPEAGETSAHDGVATATSSRPSSPDPVVNSARETLLSGSAAAT 735
                     ||:.:.:.|                     .||       |.|.:::|
Human   641 ---------NDSLAMEGP---------------------LSR-------VKSLKKSL-------- 660

  Fly   736 AAAAASAAVMMAKSPQRDDAAPKELQDRRKSMSWKTFNLKRQLSKVNMKIGGLNVNTDMESLKNS 800
                                        |:|.        |::.|
Human   661 ----------------------------RQSF--------RRIRK-------------------- 669

  Fly   801 SIFYTPKEVSPEAATPPATEEEATPEGKEDESLDDGEMATNAGAAAAASPSPAVRGKFRSSTTDS 865
                                                               ..|.||.|::...|
Human   670 ---------------------------------------------------SRVSGKKRAANASS 683

  Fly   866 PDEGASSSIASGIRRVDFEQPAGVEVERPNNLPLADAPAPLKPARQKFKEKSRDQRLLSVPNIKY 930
            ..:.|::.:|        ||....:||             :.|.:::.:.:|.|..|
Human   684 KLQEANAQLA--------EQACPHDVE-------------MTPVQRRIEPRSADDSL-------- 719

  Fly   931 QPRDSRGGARNLKNDVSPLMGGGGGGGGVVGASSGIGGSVAGGKKIHKLDGTFSRSRSSSMSSID 995
                                             ||:
Human   720 ---------------------------------SGV----------------------------- 722

  Fly   996 MSSSESVTCLAFIESYAKRNDILTLVPTLWIGTSFGSILTLFITMPERDV----RKSQPVLITIN 1056
                  |.||.|.:::.:  |.....||:|.||:.||:....:.:|...|    |..|.|...:
Human   723 ------VRCLYFADTFLR--DGAHHGPTMWAGTNSGSVFAYALEVPAAAVGGEKRPEQAVEAVL- 778

  Fly  1057 GGPVVRL--KGSITSMSFLDSYGSIIPYTFETWRDEKRDNKDRTPTKSSSRTSPTFTPTTANTLS 1119
             |..|:|  :..:.:::.||..|..:|..:|..||.
Human   779 -GKEVQLMHRAPVVAIAVLDGRGRPLPEPYEASRDL----------------------------- 813

  Fly  1120 NTSVAGGASAGGGAGGGGGAGGGAASGGAAAGGPAGGGAGAGSAAGAAGGVGSGVTSGGGMSSSS 1184
                                        |.|....||.|
Human   814 ----------------------------AQAPDMQGGHA-------------------------- 824

  Fly  1185 ASSSGISGSVSTGLETLTDRQYIVIASEKQTKVFDV------------ANQ-CCINRIQLSEMDF 1236
                                  ::||||:|.|||.:            |:: |.:.::.|:  .|
Human   825 ----------------------VLIASEEQFKVFTLPKVSAKTKFKLTAHEGCRVRKVALA--TF 865

  Fly  1237 AVKAETITMKD--GSCLATYLSNGHLMVHSLPSLKLLLDTDFLPLMELSFQTKCKQGIVDPMLSI 1299
            |    ::..:|  .:|||...:.|.:.|.|:|.|:        |.:..|    |
Human   866 A----SVACEDYAETCLACLTNLGDVHVFSVPGLR--------PQVHYS----C----------- 903

  Fly  1300 WGQQIIVHEDTTQISKIFC-FSHKGHGLYMASPTEIQKFTISSE-----FCQFILEMMGEL---- 1354
                 |..||.:.|:.  | |:..|.|.|:.||:|.::|::|:.     .|...:....:.
Human   904 -----IRKEDISGIAS--CVFTRHGQGFYLISPSEFERFSLSARNITEPLCSLDINWPRDATQAS 961

  Fly  1355 YTVHEMPEQPKEGFFKGLFGGGAKLLDREELFGEQSGKPNRSVARHIPGPNLEQL 1409
            |.:.|.|:..:..      |..:.||..:.|.|  |..|..|:.   |||.::::
Human   962 YRIRESPKLSQAN------GTPSILLAPQSLDG--SPDPAHSMG---PGPQVQRV 1005

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tomosyn	NP_001162735.1	WD40	52..257	CDD:295369	63/227 (28%)
		WD40	<55..257	CDD:225201	63/224 (28%)
		WD40 repeat	95..133	CDD:293791	10/39 (26%)
		WD40 repeat	138..184	CDD:293791	10/46 (22%)
		WD40 repeat	192..226	CDD:293791	11/33 (33%)
		LLGL	269..375	CDD:285555	33/105 (31%)
		R-SNARE_STXBP5_6	1403..1463	CDD:277226	2/7 (29%)
LLGL1	XP_011522151.1	LLGL	280..379	CDD:285555	33/105 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1983
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000702
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X453
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.810