Protein Alignment Tomosyn and sro7

DIOPT Version :10

• Sequence 1: NP_727628.3
• Gene: Tomosyn / 32217
• FlyBaseID: FBgn0030412
• Length: 1470
• Species: Drosophila melanogaster
• Sequence 2: NP_593006.1
• Gene: sro7 / 2542372
• PomBaseID: SPAC1F3.03
• Length: 1004
• Species: Schizosaccharomyces pombe
• Alignment Length: 1105
• Identity: 203/1105 - (18%)
• Similarity: 356/1105 - (32%)
• Gaps: 310/1105 - (28%)

  Fly    44 RHGFPYSPTSFAFDPVQKLLAIGDKSGYIRILGRPGVDAHAKHEGESECAVLFAQFLVNEGALVT 108
            |.||..:|..:..|..|.||||...:..|.|.|:    .|.:.....:|:.: ....:....|:.
pombe    37 RFGFSLNPVLWCLDHQQGLLAIVSSTNRIYIYGK----QHVQSVIVPDCSTI-VHIALCAAYLIV 96

  Fly   109 VTADDTIHLWSIRQ----KTPRIVQSLKFQRERVTCIHLPVGSKWLYVGTEKG------------ 157
            :.:.:|:..:.:.:    ..|.....||   ::|||........|::.|...|
pombe    97 IDSRNTVLSYPLMKHRDLSKPAATYFLK---QKVTCTVTDPTIDWVFFGMSDGSVVPWDVTRHCL 158

  Fly   158 ------NIHVVHIDTFALSGYIINWNKAIEVVRTSH---PG---AVIALCDNPLDANKLLIAFEC 210
                  |::|...:.:.:.||             |:   ||   .|:::..:|.|...:|||:..
pombe   159 GKFKVPNLYVPRHEEWRMMGY-------------SYAPVPGKLSPVVSVQIHPKDLGVILIAYPD 210

  Fly   211 GLLVLWDLKA----KCAELRWQAAEA-------------VKSLAWHYEGKYFVSSHTDGSICSW- 257
            | :||:.::.    :..||.:.....             ||.:.|...|.:|||.:||.:...|
pombe   211 G-VVLYSIRTDEVIRFYELEYAPGSTAAVLSPHNYRRPIVKGIEWSPWGDHFVSYYTDSTFAFWD 274

  Fly   258 -----PTKPQAKPQSQVCPHAKINKDGNAEKCKPIYKV------DLKSSATGETFTIFSGGMPSE 311
                 |.:.:....|.:..:..:.::....:.:||..:      |...|     |.:..||:|.|
pombe   275 VDQEYPVQVRNFVDSNIHTYTPMQRNPPKTELEPIRSMRWCCCEDPTVS-----FILMLGGLPKE 334

  Fly   312 ---KG----SKSNCITVMVGKATTVLEMEHAVCDFITLCENP-----WP------------CETQ 352
               ||    |..|            |..:..|..|.....||     :|            ..:.
pombe   335 APVKGISLFSYRN------------LPAKKDVETFAEFFANPNSQRFFPFIDIPPVRDMLVIPSS 387

  Fly   353 EPY-------AIAVLLQYD--LVLIDLLTPGFPCFESPYPMDLHESPVTCCTYLTDCPSDL-VPA 407
            .|:       ...:||..|  |.|:|:.|....      .|.|...|..|  :|.   ||. |.|
pombe   388 SPHYNGSHNPKNLLLLSEDNSLSLLDISTGNIS------NMSLSIPPSLC--FLA---SDFRVIA 441

  Fly   408 FYSVGR----------TTTSKKSCFSEREWPISGGEWSPASCSYSE-----IVITGHQDGSLKFW 457
            |.:|.:          :..|..||       :.||..||......:     |..||.   ||..|
pombe   442 FQTVTKKVWNQIEDTISVNSHYSC-------LFGGSPSPGYLKKLDERNLLITSTGL---SLSIW 496

  Fly   458 DSGAGTL--QILYKLKTAKMFEK---PRSHVAHSHPESDNPLAVHLIFLCSESRRLCVAGAMGQV 517
            |...|.:  .:...|..:.:..|   |.:.:..:...:.||     .|.|::|        .|:|
pombe   497 DISQGFMNPSLCVNLDFSSVMRKHLTPSAFITTASFSTYNP-----EFSCADS--------FGRV 548

  Fly   518 MLFKFRK-------------VESTSEVLVLE--------------------------IPILYEN- 542
            ::.| ||             :....:.||||                          :.|.|::
pombe   549 IVCK-RKNHKENLPAQLANGIYRLDDTLVLEGTLHAQYYIDLKRGRVTLNQMSNIGFVCIGYQDG 612

  Fly   543 ---FDDIYGTSPECD-FLTGHQVQKAESSDSDKTAECSLKVRNGAQRKPPGFQSQLVCLTTGPNR 603
               ..|:.|....|: .::...:::....|.|........|.|     |.|..|. :.:.||..|
pombe   613 GITIIDMRGPHILCNTSISELGLERRGKPDPDFLTSAEFVVMN-----PKGSPSS-IYVVTGTYR 671

  Fly   604 RNVQVTSLCISSSYGLMAYGTEYGLVIIDIIQKICLLSVACPDLYGAHDPYSRTPKSPKRIENKE 668
            ....:..:..|||....||......:.|..|.|||.|:                       ::.:
pombe   672 GMTLLFRIDPSSSGRFSAYFESSRQLDIKNIYKICSLT-----------------------QDGQ 713

  Fly   669 EQSRSPSSDQLNDTTSPDSPSLEFVPEAGETSAHDGVATATSSRPSSPD---PVVNSARETLLSG 730
            ..:.:.||.|......|....|.::.::|.:     |....:::..:.|   ||...|...|.:.
pombe   714 IATATGSSLQSVGYPLPQEVFLVYIGDSGIS-----VFNKINNQVGNLDWRKPVCCRAALVLSTV 773

  Fly   731 SAAATAAAAASAAVMMAKSPQRDDAAPKELQDRRKSMSWKTFNLKRQLSKVNMKIGGLNVNTDME 795
            |....:....::.:                     |::|.:....|:..|:.     |.::.|..
pombe   774 SKHMGSVVCVNSDL---------------------SVNWYSLPNLREERKMQ-----LPLDIDKN 812

  Fly   796 SLKNSSIFYTPKEVSPEAATPPATEEEATPEGKEDESLDDGEMATNAGAAAAASPSPAVRGKFRS 860
            .||...|......:.|...............|:...:|....:.|:..:.....||.::......
pombe   813 RLKEGDILGNGDYIFPTLGAHELAFGCVLGSGRTLANLAPMMLITHNASHVPPRPSKSLWNWLLG 877

  Fly   861 STTDSPDE-----GASSSIASGIRRVDFEQPAGVEVERPNNLPLADAPAPLKPARQKFKEKSRDQ 920
            ..:.|.:|     |..:...|.:..::..:............||...|:....:.|.:....|.|
pombe   878 EQSTSAEELDILLGGENRAESKVHTLETPKVISARPAESVKQPLTPVPSMTSQSAQSYIPPRRQQ 942

  Fly   921 R----LLSVPNIKYQPRDSRGGARNLKNDVSPLMGGGGGGGGVVGASSGIGGSVAGGKKIHKLDG 981
            :    ...:.:...|..:..||..|..:|:..:....         ::.|..|:||.||...|.|
pombe   943 QQKGFFAQINDHLAQRGNMLGGIENTMDDLEEMSAEW---------ANEIKDSLAGTKKDLILSG 998

  Fly   982  981
            pombe   999  998

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tomosyn	NP_727628.3	WD40	<41..257	CDD:441893	53/257 (21%)
		WD40 repeat	95..133	CDD:293791	4/41 (10%)
		WD40 repeat	138..184	CDD:293791	10/63 (16%)
		WD40 repeat	192..226	CDD:293791	9/37 (24%)
		LLGL	268..376	CDD:462446	27/146 (18%)
		R-SNARE_STXBP5_6	1403..1463	CDD:277226
sro7	NP_593006.1	WD40	45..283	CDD:475233	51/259 (20%)
		Lgl_C	524..899	CDD:400768	71/448 (16%)