DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tomosyn and tom-1

DIOPT Version :9

Sequence 1:NP_001162735.1 Gene:Tomosyn / 32217 FlyBaseID:FBgn0030412 Length:1470 Species:Drosophila melanogaster
Sequence 2:NP_001300429.1 Gene:tom-1 / 172209 WormBaseID:WBGene00006594 Length:1255 Species:Caenorhabditis elegans


Alignment Length:1548 Identity:466/1548 - (30%)
Similarity:681/1548 - (43%) Gaps:381/1548 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 KFTFKGVLDGFRQSVQPQATRQEQEIQEQLKADHFTLKKTFRHGFPYSPTSFAFDPVQKLLAIGD 67
            |..|...:||.|.    ...|.|..:.|:::::|....:..|||.|..|..||:||||:|:|||.
 Worm     5 KKKFASAIDGLRS----LHNRTEINVDEKIQSEHCRFTRVVRHGLPEDPRCFAYDPVQRLIAIGT 65

  Fly    68 KSGYIRILGRPGVDAHAKHE-GESECAVLFAQFLVNEGALVTVTADDTIHLWSIRQKTPRIVQSL 131
            ..|:|||:|..|||...||| ||   .||..|||||||.|:|....|:||||:.||||..||.::
 Worm    66 GRGHIRIIGDAGVDYLLKHESGE---PVLHMQFLVNEGGLITSCGTDSIHLWNYRQKTAEIVHTV 127

  Fly   132 KFQRERVTCIHLPVGSKWLYVGTEKGNIHVVHIDTFALSGYIINWNKAIEVVRTSHPGAVIALCD 196
            :..:|.|:||||||..|||::||:|||::.:.:::|.||.|:|||||||::....|||.|..|..
 Worm   128 QLSKESVSCIHLPVAGKWLFIGTDKGNVYFLCLNSFLLSPYVINWNKAIDLSCRVHPGPVRQLAV 192

  Fly   197 NPLDANKLLIAFECGLLVLWDLKAKCAELRWQAAEAVKSLAWHYEGKYFVSSHTDGSICSWPTKP 261
            :|.:..||||.::.|::|.|:|..:..: |:.....:||:.||::|:..::.:.||||..:..|.
 Worm   193 SPAENTKLLIVYDKGIVVQWNLGTREVD-RYPLDPPIKSVNWHFDGRQILTGNVDGSISLYNHKK 256

  Fly   262 QAKPQSQVCPHAKINKDGNAEKCKPIYKVDLKSSATGETFTIFSGGMPSEKGSKSNCITVMV-GK 325
            ..:...:..||       .:..|:||.:|:.|..:..|:..:||||||::.|.....:|::. ||
 Worm   257 STEAIQRTTPH-------GSGPCRPIQQVEWKHMSETESIIMFSGGMPTDDGLPMPALTILKGGK 314

  Fly   326 ATTVLEMEHAVCDFITLCENPWPCETQEPYAIAVLLQYDLVLIDLLTPGFPCFESPYPMDLHESP 390
            :.|||||:..:..||.|.:|.|....|.|:::||||::|.:::||...|.|..|||:.|::||||
 Worm   315 SATVLEMDWPIIQFIPLNQNIWNSIPQCPHSVAVLLKHDFMVLDLNQNGHPVIESPHAMNIHESP 379

  Fly   391 VTCCTYLTDCPSDLVPAFYSVGRTTTSKKSCFSEREWPISGGEWSPASCSYSEIVITGHQDGSLK 455
            |||..|.:|||.||:.|...||....:|:  ||.|.||::||.....:..:.|:|:|||:|||||
 Worm   380 VTCMAYYSDCPLDLIGALTLVGTKQRNKE--FSARSWPVTGGLGRECATGHQELVVTGHKDGSLK 442

  Fly   456 FWDSGAGTLQILYKLKTAKMFEK-----PRSHVAHSHPESDNPLAVHLIFLCSESRRLCVAGAMG 515
            ||......||||||||::..||:     ....|:|         ||..|.||.|||:|.|||..|
 Worm   443 FWQETGEHLQILYKLKSSSHFERLEEMETSDKVSH---------AVKYIELCLESRQLLVAGISG 498

  Fly   516 QVMLFKFRKVESTSEVLVLEIPILYENFDDIYGTSPECDF-------------------LTGHQV 561
            ||.||:|.|.|....:.|:.||:|    .::....|..||                   ::....
 Worm   499 QVTLFRFTKQEICGTIAVVNIPLL----GNLSSNLPNNDFDKSPVPNGPGKEIRRQRKIVSREST 559

  Fly   562 QKAESSDSDKTAECSLKVRNGAQRKPPGFQSQLVCLTTGPNRRNV-QVTSLCISSSYGLMAYGTE 625
            ...::|||........|||....::||||..:|.|.....:...| |:|::|::||||::|.||.
 Worm   560 NSLDTSDSGDERIVPFKVRGAPVKRPPGFVPELACFVPWHSHAKVDQITTICLNSSYGIIAIGTS 624

  Fly   626 YGLVIIDIIQKICLLSVACPDLYGAHDPYSRTPKSPKRIENKEEQSRSPSSDQLNDTTSP----- 685
            .||.::|..|...:.|....:|||: ||   ||             ....|.||:|..||     
 Worm   625 SGLALVDTTQCALIYSWTTNELYGS-DP---TP-------------AIQLSMQLSDAASPLEIDE 672

  Fly   686 --DSPSLEFVPEAGETSAHDGVATATSSRPSS------------PDPVVNSARETLLSGSAAA-- 734
              :..:|.:..:.|..:..   :|..|..|||            |....||:.:   ||....  
 Worm   673 FENDDTLIYNTDTGNYTLR---STRNSLTPSSNGFLHPGEMPTRPKSAANSSNK---SGGMMGLF 731

  Fly   735 ---TAAAAASAAVMMAKSPQRDDAAPKELQDRRKSMSWKTFNLKRQLSKVNMKIGGLNVNTDMES 796
               ||..||:.               :|.....:|.|                     ..||.  
 Worm   732 RRNTAELAATI---------------RERYQGNRSES---------------------ATTDR-- 758

  Fly   797 LKNSSIFYTPKEVSPEAATPPATEEEATPEGKEDESLDDGEMATNAGAAAAASPSPAVRGKF--R 859
                      .:|.....|||.|..|             |.....||.      |.:|:|.|  |
 Worm   759 ----------PDVEHRGETPPPTPNE-------------GNKVQKAGR------SHSVKGSFIRR 794

  Fly   860 SSTTDSPDEGASSSIASGIRRVDFEQPAGVEVERPNNLPLADAPAPLKPARQKFKEKSRDQRLLS 924
            .:.:.|..|.....|     .||.:..:|:|..|              .......|:...|    
 Worm   795 FAKSSSSKEKKEVKI-----EVDNQSNSGIERSR--------------SFHSHISEEGDSQ---- 836

  Fly   925 VPNIKYQPRDSRGGARNLKNDVSPLMGGGGGGGGVVGASSGIGGSVAGGKKIHKLDGTFSRSRSS 989
                    |:|....|.| |..||                                .|.|:|...
 Worm   837 --------RESPSSGRQL-NTSSP--------------------------------STSSQSLER 860

  Fly   990 SMSSIDMSSSESVTCLAFIESYAKRNDILTLVPTLWIGTSFGSILTLFITMPERDVRKSQPVLIT 1054
            |||:   ...||:|.|:||.||:|:|| ..:.|.||:|||.|:.|.|.:.:||.....:..|..:
 Worm   861 SMST---QPQESITSLSFIHSYSKKND-SKMSPCLWVGTSAGASLALNLILPEDRFTSTIVVAPS 921

  Fly  1055 ING------GPVVRLKGSITSMSFLDSYGSIIPYTFETWRDEKRDNKDRTPTKSSSRTSPTFTPT 1113
            :.|      |.||||||.:.|.||:|:...||....|::::         ..|..|.|||.    
 Worm   922 VRGRKHCYYGTVVRLKGQVISQSFMDNTFCIISPASESYKE---------AAKEQSATSPD---- 973

  Fly  1114 TANTLSNTSVAGGASAGGGAGGGGGAGGGAASGGAAAGGPAGGGAGAGSAAGAAGGVGSGVTSGG 1178
              .:|.|.                                                |.:..:...
 Worm   974 --RSLLNR------------------------------------------------VNTKASLAP 988

  Fly  1179 GMSSSSASSSGISGSVSTGLETLTDRQYIVIASEKQTKVFDVANQCCINRIQLSEMDF--AVKAE 1241
            ..|||..|:..||             |.:::|:|.:.||..:..   .:::.:.:.|.  .|||.
 Worm   989 QYSSSIDSNDEIS-------------QILIVAAENEVKVVALPT---FSQLYVQKFDEIPLVKAT 1037

  Fly  1242 TITMKDGSCLATYLSNGHLMVHSLPSLKLLLDTDFLPLMELSFQTKCKQGIVDPMLSIWGQQIIV 1306
            ...::...||....:.|.:::.|||||::|..:...|                            
 Worm  1038 PTHIRGYPCLMCLSAAGQIIMLSLPSLRILQTSTIFP---------------------------- 1074

  Fly  1307 HEDTTQISKIFC----FSHKGHGLYMASPTEIQKFTISSEFCQFILEMMGELYTVHEMPEQPK-E 1366
              .:.:|....|    ||..|.|:||||.||::|:|:.||..:...|.:|||:...||||||| .
 Worm  1075 --HSVEIDDPLCQKTAFSDHGLGVYMASQTEMEKYTMCSEIAEQTGESLGELFVPCEMPEQPKNN 1137

  Fly  1367 GFFKG---LFGGGAK--LLDREELFGEQSG-------KPNRSVARHIPGPNLEQLGQRASTAASE 1419
            .|.||   :|||..:  ..|.:.:..|..|       .|.|||||.||||:::.  .||......
 Worm  1138 SFLKGVSSIFGGTPRNDPNDIDAILSENMGVKNSSGVNPMRSVARTIPGPSVQM--DRAQAGGVS 1200

  Fly  1420 ISRAHQLAM----ERGEKLNLLEERAERMANTAQDFSGTAHQLMLKYKDKKWY 1468
            ..:|..:|:    ||.||||...:..|.:.|.|...|....:|:.||:.||||
 Worm  1201 AGQAAAMALQNLNERTEKLNATVDATENLKNNAMSLSSRTGKLVEKYEKKKWY 1253

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TomosynNP_001162735.1 WD40 52..257 CDD:295369 96/205 (47%)
WD40 <55..257 CDD:225201 95/202 (47%)
WD40 repeat 95..133 CDD:293791 21/37 (57%)
WD40 repeat 138..184 CDD:293791 26/45 (58%)
WD40 repeat 192..226 CDD:293791 10/33 (30%)
LLGL 269..375 CDD:285555 37/106 (35%)
R-SNARE_STXBP5_6 1403..1463 CDD:277226 18/63 (29%)
tom-1NP_001300429.1 WD40 50..>256 CDD:392136 96/209 (46%)
WD40 repeat 51..84 CDD:293791 18/32 (56%)
WD40 repeat 91..129 CDD:293791 21/37 (57%)
WD40 repeat 134..184 CDD:293791 26/49 (53%)
WD40 repeat 190..221 CDD:293791 10/31 (32%)
WD40 repeat 228..267 CDD:293791 10/38 (26%)
LLGL 264..364 CDD:369834 37/106 (35%)
R-SNARE_STXBP5_6 1188..1248 CDD:277226 16/61 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C160166034
Domainoid 1 1.000 368 1.000 Domainoid score I482
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 649 1.000 Inparanoid score I427
Isobase 1 0.950 - 0.861654 Normalized mean entropy S4092
OMA 1 1.010 - - QHG49198
OrthoDB 1 1.010 - - D53111at33208
OrthoFinder 1 1.000 - - FOG0000702
OrthoInspector 1 1.000 - - oto19211
orthoMCL 1 0.900 - - OOG6_104979
Panther 1 1.100 - - LDO PTHR10241
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2301
SonicParanoid 1 1.000 - - X453
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1413.890

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