DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tomosyn and Llgl1

DIOPT Version :9

Sequence 1:NP_001162735.1 Gene:Tomosyn / 32217 FlyBaseID:FBgn0030412 Length:1470 Species:Drosophila melanogaster
Sequence 2:NP_001152877.1 Gene:Llgl1 / 16897 MGIID:102682 Length:1062 Species:Mus musculus


Alignment Length:1553 Identity:328/1553 - (21%)
Similarity:523/1553 - (33%) Gaps:583/1553 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MKKFTFKGVLDGFRQSVQPQATRQEQEIQEQLKADHFTLKKTFRHGFPYSPTSFAFDPVQKLLAI 65
            |.||.|:      ||...||        :|:||.:.|...||..||||..|::.||||..:::||
Mouse     1 MMKFRFR------RQGADPQ--------REKLKQELFAFHKTVEHGFPNQPSALAFDPELRIMAI 51

  Fly    66 GDKSGYIRILGRPGVDAHAKHEGESECAVLFAQFLVNEGALVTVTADDTIHLWSI--RQKTPRIV 128
            |.:||.::|.|.|||:....|  .....|....||..:|.|:|:..|.::|||.|  ......:.
Mouse    52 GTRSGAVKIYGAPGVEFTGLH--RDAATVTQMHFLPGQGRLLTLLDDSSLHLWEIIHHNGCAHLE 114

  Fly   129 QSLKF---------------QRERVTCIHLPVGSKWLYVGTEKGNIHVVHIDTFA-LSGYIINWN 177
            :.|.|               ...|||.:.|..|:. ..:|||.|:|..:.:.|.| |.|..:   
Mouse   115 EGLSFHPPSRPSFDNASFPASLTRVTVVLLVAGNT-AALGTESGSIFFLDVATLALLEGQTL--- 175

  Fly   178 KAIEVVRTSHP---------GAVIALCDNPLDANKLLIAFECGLLVLWDLKAKCAELRWQAAEAV 233
             :.:||..|.|         |.|.:|..:..|.:|:||.:..||||:|....:..:..:...:.:
Mouse   176 -SPDVVLRSVPDDYRCGKALGPVESLQGHLQDPSKILIGYSRGLLVIWSQATQSVDNVFLGNQQL 239

  Fly   234 KSLAWHYEGKYFVSSHTDGSICSWPT----KPQAKPQSQVCPHAKINKDGNAEKCKPIYKVDLKS 294
            :||.|..:|...:|||:|||...|.|    .|..:|.....|:...       .||.|.|:..:|
Mouse   240 ESLCWGRDGSSIISSHSDGSYAIWSTDTGSPPTLQPTVVTTPYGPF-------PCKAINKILWRS 297

  Fly   295 SATGETFTIFSGGMPSEKGSKSNCITVMVGKATTVLEMEHAVCDFITLCENPWPCETQEPYAIAV 359
            ..:|:.|.|||||||.......:|::|:..:....|:....|.||.|:.......|...|.|:||
Mouse   298 CESGDHFIIFSGGMPRASYGDRHCVSVLRAETLVTLDFTSRVIDFFTVHSTQPEDECDNPQALAV 362

  Fly   360 LLQYDLVLIDLLTPGFPCFESPYPMDLHESPVTCCTYLTDCPSDLVPAFYSVGRTTTSKKSCFSE 424
            ||:.:||::||.|||:|...:||...||.|.:||..::.:.||.|.....|.|. ..|.:...|.
Mouse   363 LLEEELVVLDLQTPGWPAVPAPYLAPLHSSAITCSAHVANVPSKLWARIVSAGE-QQSPQPASSA 426

  Fly   425 REWPISGGEWSPASCSYSEIVITGHQDGSLKFWDSGAGTLQILYKLKTAKMFEKPRSH------- 482
            ..|||:||.......|...:::|||:||:::|||:....|:.||||.||.:|:....|       
Mouse   427 LSWPITGGRNLAQEPSQRGLLLTGHEDGTVRFWDASGVALRPLYKLSTAGLFQTDCEHADSLAQA 491

  Fly   483 ----------VAHSHPESDNP-LAVHLIFLCSESRRLCVAGAMGQVMLFKFRKVESTSEVLVLEI 536
                      |....|.||:| |.:..:.||..:.::.|||..|||::.:..:|.:...|.|..:
Mouse   492 VEDDWPPFRKVGCFDPYSDDPRLGIQKVALCKYTAQMVVAGTAGQVLVLELSEVPAEHAVSVANV 556

  Fly   537 PILYENFDDIYGTSPECDFLTGHQVQKAESSDSDKTAECSLKVRNGAQRKPPGFQSQLVCLTTGP 601
            .:|.:.         |.....||:               .|....|....|.|||.:::.....|
Mouse   557 DLLQDR---------EGFTWKGHE---------------RLNPHTGLLPWPAGFQPRMLIQCLPP 597

  Fly   602 NRRNVQVTSLCISSSYGLMAYGTEYGLVIIDIIQKICLLSVACPDLYGAHDPYSRTPKSPKRIEN 666
                ..||::.:.:.:.|:|:||.:|..:.|..:|..:|              :|....|     
Mouse   598 ----AAVTAVTLHAEWSLVAFGTSHGFGLFDYQRKSPVL--------------ARCTLHP----- 639

  Fly   667 KEEQSRSPSSDQLNDTTSPDSPSLEFVPEAGETSAHDGVATATSSRPSSPDPVVNSARETLLSGS 731
                         ||:.:.:.|                                           
Mouse   640 -------------NDSLAMEGP------------------------------------------- 648

  Fly   732 AAATAAAAASAAVMMAKSPQRDDAAPKELQDRRKSMSWKTFNLKRQLSKVNMKIGGLNVNTDMES 796
                                                          ||:|             :|
Mouse   649 ----------------------------------------------LSRV-------------KS 654

  Fly   797 LKNSSIFYTPKEVSPEAATPPATEEEATPEGKEDESLDDGEMATNAGAAAAASPSPAVRGKFRSS 861
            ||.|                                                     :|..||. 
Mouse   655 LKKS-----------------------------------------------------LRQSFRR- 665

  Fly   862 TTDSPDEGASSSIASGIRRVDFEQPAGVEVERPNNLPLADAPAP----LKPARQKFKEKSRDQRL 922
                    ...|..||.:|.    ||.....:..|..||:...|    :.|.:::.:.:|.|..|
Mouse   666 --------IRKSRVSGKKRT----PAASSKLQEANAQLAEQTCPHDLEMTPVQRRIEPRSADDSL 718

  Fly   923 LSVPNIKYQPRDSRGGARNLKNDVSPLMGGGGGGGGVVGASSGIGGSVAGGKKIHKLDGTFSRSR 987
                                                     ||:                     
Mouse   719 -----------------------------------------SGV--------------------- 721

  Fly   988 SSSMSSIDMSSSESVTCLAFIESYAKRNDILTLVPTLWIGTSFGSILTLFITMPER----DVRKS 1048
                          |.||.|.:::.:  |.....||:|.||:.||:....:.:|..    :.|..
Mouse   722 --------------VRCLYFADTFLR--DATHHGPTMWAGTNSGSVFAYALEVPAATAGGEKRPE 770

  Fly  1049 QPVLITINGGPVVRL--KGSITSMSFLDSYGSIIPYTFETWRDEKRDNKDRTPTKSSSRTSPTFT 1111
            |.|...:  |..|:|  :..:.:::.||..|..:|..:|..||.                     
Mouse   771 QAVEAVL--GKEVQLMHRAPVVAIAVLDGRGRPLPEPYEASRDL--------------------- 812

  Fly  1112 PTTANTLSNTSVAGGASAGGGAGGGGGAGGGAASGGAAAGGPAGGGAGAGSAAGAAGGVGSGVTS 1176
                                                |.|....||.|                  
Mouse   813 ------------------------------------AQAPDMQGGHA------------------ 823

  Fly  1177 GGGMSSSSASSSGISGSVSTGLETLTDRQYIVIASEKQTKVFDV------------ANQ-CCINR 1228
                                          ::||||:|.|||.:            |:: |.:.:
Mouse   824 ------------------------------VLIASEEQFKVFTLPKVSAKTKFKLTAHEGCRVRK 858

  Fly  1229 IQLSEMDFAVK---AETITMKDGSCLATYLSNGHLMVHSLPSLKLLLDTDFLPLMELSFQTKCKQ 1290
            :.|:.....:.   |||       |||...:.|.:.|.|:|.|:        |.:..|    |  
Mouse   859 VALATFASVMSEDYAET-------CLACLTNLGDVHVFSVPGLR--------PQVHYS----C-- 902

  Fly  1291 GIVDPMLSIWGQQIIVHEDTTQISKIFC-FSHKGHGLYMASPTEIQKFTISSEFCQFILEMMGEL 1354
                          |..||.:.|:.  | |:..|.|.|:.||:|.::|::|:   :.|.|.:..|
Mouse   903 --------------IRKEDISGIAS--CVFTRHGQGFYLISPSEFERFSLSA---RNITEPLCSL 948

  Fly  1355 -------YTVHEMPEQPKEGFFKGLFGGGAKLLDREELFGEQS--GKPN-----RSVARHIPGPN 1405
                   .|...:.|.||.....|         .|:.:...:|  |.|:     |:.....|...
Mouse   949 DISWPQNATQPRLQESPKLSQANG---------TRDIILAPESCEGSPSSAHSKRADTMEPPEAA 1004

  Fly  1406 LEQLG-QRASTAASEISRAHQLAMER-GEKLNLLEERAERMANTAQDFSGTAHQLMLK 1461
            |..:. ..|::..:.:.....:.:|. .:.|...|:..:.:.|...|.:..|:.|::|
Mouse  1005 LSPVSIDSAASGDTMLDTTGDVTVEYVKDFLGSPEDSEKNLRNLEADDACRAYTLLIK 1062

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TomosynNP_001162735.1 WD40 52..257 CDD:295369 68/231 (29%)
WD40 <55..257 CDD:225201 68/228 (30%)
WD40 repeat 95..133 CDD:293791 11/39 (28%)
WD40 repeat 138..184 CDD:293791 14/46 (30%)
WD40 repeat 192..226 CDD:293791 10/33 (30%)
LLGL 269..375 CDD:285555 35/105 (33%)
R-SNARE_STXBP5_6 1403..1463 CDD:277226 10/61 (16%)
Llgl1NP_001152877.1 WD40 repeat 38..73 CDD:293791 15/36 (42%)
WD 1 38..71 14/32 (44%)
WD 2 78..119 12/40 (30%)
WD40 repeat 116..174 CDD:293791 16/58 (28%)
WD 3 139..175 13/36 (36%)
WD40 repeat 182..234 CDD:293791 14/51 (27%)
WD40 <195..>310 CDD:225201 37/121 (31%)
WD 4 199..233 10/33 (30%)
WD40 repeat 239..282 CDD:293791 14/42 (33%)
WD 5 239..271 12/31 (39%)
LLGL 279..378 CDD:285555 35/105 (33%)
WD 6 289..331 14/41 (34%)
WD 7 339..373 13/33 (39%)
WD 8 395..473 27/78 (35%)
WD 9 517..592 21/98 (21%)
WD 10 601..662 22/247 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 667..688 6/24 (25%)
WD 11 722..782 17/63 (27%)
WD 12 791..843 20/156 (13%)
WD 13 848..901 15/67 (22%)
WD 14 915..938 8/22 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 980..1002 4/21 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1983
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000702
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X453
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.810

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