DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tomosyn and Llgl1

DIOPT Version :10

Sequence 1:NP_727628.3 Gene:Tomosyn / 32217 FlyBaseID:FBgn0030412 Length:1470 Species:Drosophila melanogaster
Sequence 2:NP_001152877.1 Gene:Llgl1 / 16897 MGIID:102682 Length:1062 Species:Mus musculus


Alignment Length:1553 Identity:328/1553 - (21%)
Similarity:523/1553 - (33%) Gaps:583/1553 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MKKFTFKGVLDGFRQSVQPQATRQEQEIQEQLKADHFTLKKTFRHGFPYSPTSFAFDPVQKLLAI 65
            |.||.|:      ||...||        :|:||.:.|...||..||||..|::.||||..:::||
Mouse     1 MMKFRFR------RQGADPQ--------REKLKQELFAFHKTVEHGFPNQPSALAFDPELRIMAI 51

  Fly    66 GDKSGYIRILGRPGVDAHAKHEGESECAVLFAQFLVNEGALVTVTADDTIHLWSI--RQKTPRIV 128
            |.:||.::|.|.|||:....|  .....|....||..:|.|:|:..|.::|||.|  ......:.
Mouse    52 GTRSGAVKIYGAPGVEFTGLH--RDAATVTQMHFLPGQGRLLTLLDDSSLHLWEIIHHNGCAHLE 114

  Fly   129 QSLKF---------------QRERVTCIHLPVGSKWLYVGTEKGNIHVVHIDTFA-LSGYIINWN 177
            :.|.|               ...|||.:.|..|:. ..:|||.|:|..:.:.|.| |.|..:   
Mouse   115 EGLSFHPPSRPSFDNASFPASLTRVTVVLLVAGNT-AALGTESGSIFFLDVATLALLEGQTL--- 175

  Fly   178 KAIEVVRTSHP---------GAVIALCDNPLDANKLLIAFECGLLVLWDLKAKCAELRWQAAEAV 233
             :.:||..|.|         |.|.:|..:..|.:|:||.:..||||:|....:..:..:...:.:
Mouse   176 -SPDVVLRSVPDDYRCGKALGPVESLQGHLQDPSKILIGYSRGLLVIWSQATQSVDNVFLGNQQL 239

  Fly   234 KSLAWHYEGKYFVSSHTDGSICSWPT----KPQAKPQSQVCPHAKINKDGNAEKCKPIYKVDLKS 294
            :||.|..:|...:|||:|||...|.|    .|..:|.....|:...       .||.|.|:..:|
Mouse   240 ESLCWGRDGSSIISSHSDGSYAIWSTDTGSPPTLQPTVVTTPYGPF-------PCKAINKILWRS 297

  Fly   295 SATGETFTIFSGGMPSEKGSKSNCITVMVGKATTVLEMEHAVCDFITLCENPWPCETQEPYAIAV 359
            ..:|:.|.|||||||.......:|::|:..:....|:....|.||.|:.......|...|.|:||
Mouse   298 CESGDHFIIFSGGMPRASYGDRHCVSVLRAETLVTLDFTSRVIDFFTVHSTQPEDECDNPQALAV 362

  Fly   360 LLQYDLVLIDLLTPGFPCFESPYPMDLHESPVTCCTYLTDCPSDLVPAFYSVGRTTTSKKSCFSE 424
            ||:.:||::||.|||:|...:||...||.|.:||..::.:.||.|.....|.|. ..|.:...|.
Mouse   363 LLEEELVVLDLQTPGWPAVPAPYLAPLHSSAITCSAHVANVPSKLWARIVSAGE-QQSPQPASSA 426

  Fly   425 REWPISGGEWSPASCSYSEIVITGHQDGSLKFWDSGAGTLQILYKLKTAKMFEKPRSH------- 482
            ..|||:||.......|...:::|||:||:::|||:....|:.||||.||.:|:....|       
Mouse   427 LSWPITGGRNLAQEPSQRGLLLTGHEDGTVRFWDASGVALRPLYKLSTAGLFQTDCEHADSLAQA 491

  Fly   483 ----------VAHSHPESDNP-LAVHLIFLCSESRRLCVAGAMGQVMLFKFRKVESTSEVLVLEI 536
                      |....|.||:| |.:..:.||..:.::.|||..|||::.:..:|.:...|.|..:
Mouse   492 VEDDWPPFRKVGCFDPYSDDPRLGIQKVALCKYTAQMVVAGTAGQVLVLELSEVPAEHAVSVANV 556

  Fly   537 PILYENFDDIYGTSPECDFLTGHQVQKAESSDSDKTAECSLKVRNGAQRKPPGFQSQLVCLTTGP 601
            .:|.:.         |.....||:               .|....|....|.|||.:::.....|
Mouse   557 DLLQDR---------EGFTWKGHE---------------RLNPHTGLLPWPAGFQPRMLIQCLPP 597

  Fly   602 NRRNVQVTSLCISSSYGLMAYGTEYGLVIIDIIQKICLLSVACPDLYGAHDPYSRTPKSPKRIEN 666
                ..||::.:.:.:.|:|:||.:|..:.|..:|..:|              :|....|     
Mouse   598 ----AAVTAVTLHAEWSLVAFGTSHGFGLFDYQRKSPVL--------------ARCTLHP----- 639

  Fly   667 KEEQSRSPSSDQLNDTTSPDSPSLEFVPEAGETSAHDGVATATSSRPSSPDPVVNSARETLLSGS 731
                         ||:.:.:.|                                           
Mouse   640 -------------NDSLAMEGP------------------------------------------- 648

  Fly   732 AAATAAAAASAAVMMAKSPQRDDAAPKELQDRRKSMSWKTFNLKRQLSKVNMKIGGLNVNTDMES 796
                                                          ||:|             :|
Mouse   649 ----------------------------------------------LSRV-------------KS 654

  Fly   797 LKNSSIFYTPKEVSPEAATPPATEEEATPEGKEDESLDDGEMATNAGAAAAASPSPAVRGKFRSS 861
            ||.|                                                     :|..||. 
Mouse   655 LKKS-----------------------------------------------------LRQSFRR- 665

  Fly   862 TTDSPDEGASSSIASGIRRVDFEQPAGVEVERPNNLPLADAPAP----LKPARQKFKEKSRDQRL 922
                    ...|..||.:|.    ||.....:..|..||:...|    :.|.:::.:.:|.|..|
Mouse   666 --------IRKSRVSGKKRT----PAASSKLQEANAQLAEQTCPHDLEMTPVQRRIEPRSADDSL 718

  Fly   923 LSVPNIKYQPRDSRGGARNLKNDVSPLMGGGGGGGGVVGASSGIGGSVAGGKKIHKLDGTFSRSR 987
                                                     ||:                     
Mouse   719 -----------------------------------------SGV--------------------- 721

  Fly   988 SSSMSSIDMSSSESVTCLAFIESYAKRNDILTLVPTLWIGTSFGSILTLFITMPER----DVRKS 1048
                          |.||.|.:::.:  |.....||:|.||:.||:....:.:|..    :.|..
Mouse   722 --------------VRCLYFADTFLR--DATHHGPTMWAGTNSGSVFAYALEVPAATAGGEKRPE 770

  Fly  1049 QPVLITINGGPVVRL--KGSITSMSFLDSYGSIIPYTFETWRDEKRDNKDRTPTKSSSRTSPTFT 1111
            |.|...:  |..|:|  :..:.:::.||..|..:|..:|..||.                     
Mouse   771 QAVEAVL--GKEVQLMHRAPVVAIAVLDGRGRPLPEPYEASRDL--------------------- 812

  Fly  1112 PTTANTLSNTSVAGGASAGGGAGGGGGAGGGAASGGAAAGGPAGGGAGAGSAAGAAGGVGSGVTS 1176
                                                |.|....||.|                  
Mouse   813 ------------------------------------AQAPDMQGGHA------------------ 823

  Fly  1177 GGGMSSSSASSSGISGSVSTGLETLTDRQYIVIASEKQTKVFDV------------ANQ-CCINR 1228
                                          ::||||:|.|||.:            |:: |.:.:
Mouse   824 ------------------------------VLIASEEQFKVFTLPKVSAKTKFKLTAHEGCRVRK 858

  Fly  1229 IQLSEMDFAVK---AETITMKDGSCLATYLSNGHLMVHSLPSLKLLLDTDFLPLMELSFQTKCKQ 1290
            :.|:.....:.   |||       |||...:.|.:.|.|:|.|:        |.:..|    |  
Mouse   859 VALATFASVMSEDYAET-------CLACLTNLGDVHVFSVPGLR--------PQVHYS----C-- 902

  Fly  1291 GIVDPMLSIWGQQIIVHEDTTQISKIFC-FSHKGHGLYMASPTEIQKFTISSEFCQFILEMMGEL 1354
                          |..||.:.|:.  | |:..|.|.|:.||:|.::|::|:   :.|.|.:..|
Mouse   903 --------------IRKEDISGIAS--CVFTRHGQGFYLISPSEFERFSLSA---RNITEPLCSL 948

  Fly  1355 -------YTVHEMPEQPKEGFFKGLFGGGAKLLDREELFGEQS--GKPN-----RSVARHIPGPN 1405
                   .|...:.|.||.....|         .|:.:...:|  |.|:     |:.....|...
Mouse   949 DISWPQNATQPRLQESPKLSQANG---------TRDIILAPESCEGSPSSAHSKRADTMEPPEAA 1004

  Fly  1406 LEQLG-QRASTAASEISRAHQLAMER-GEKLNLLEERAERMANTAQDFSGTAHQLMLK 1461
            |..:. ..|::..:.:.....:.:|. .:.|...|:..:.:.|...|.:..|:.|::|
Mouse  1005 LSPVSIDSAASGDTMLDTTGDVTVEYVKDFLGSPEDSEKNLRNLEADDACRAYTLLIK 1062

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TomosynNP_727628.3 WD40 <41..257 CDD:441893 75/242 (31%)
WD40 repeat 95..133 CDD:293791 11/39 (28%)
WD40 repeat 138..184 CDD:293791 14/46 (30%)
WD40 repeat 192..226 CDD:293791 10/33 (30%)
LLGL 268..376 CDD:462446 36/107 (34%)
R-SNARE_STXBP5_6 1403..1463 CDD:277226 10/61 (16%)
Llgl1NP_001152877.1 WD40 repeat 38..73 CDD:293791 15/36 (42%)
WD 1 38..71 14/32 (44%)
WD 2 78..119 12/40 (30%)
WD40 repeat 116..174 CDD:293791 16/58 (28%)
WD 3 139..175 13/36 (36%)
WD40 repeat 182..234 CDD:293791 14/51 (27%)
WD 4 199..233 10/33 (30%)
WD40 repeat 239..282 CDD:293791 14/42 (33%)
WD 5 239..271 12/31 (39%)
LLGL 278..379 CDD:462446 36/107 (34%)
WD 6 289..331 14/41 (34%)
WD 7 339..373 13/33 (39%)
WD 8 395..473 27/78 (35%)
WD 9 517..592 21/98 (21%)
WD 10 601..662 22/247 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 667..688 6/24 (25%)
WD 11 722..782 17/63 (27%)
WD 12 791..843 20/156 (13%)
WD 13 848..901 15/67 (22%)
WD 14 915..938 8/22 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 980..1002 4/21 (19%)

Return to query results.
Submit another query.