Protein Alignment Tomosyn and l(2)gl

DIOPT Version :10

• Sequence 1: NP_727628.3
• Gene: Tomosyn / 32217
• FlyBaseID: FBgn0030412
• Length: 1470
• Species: Drosophila melanogaster
• Sequence 2: XP_313781.6
• Gene: l(2)gl / 1274630
• VectorBaseID: AGAMI1_014062
• Length: 1247
• Species: Anopheles gambiae
• Alignment Length: 1330
• Identity: 310/1330 - (23%)
• Similarity: 514/1330 - (38%)
• Gaps: 334/1330 - (25%)

  Fly    20 QATRQEQEIQEQLKADHFTLKKTFRHGFPYSPTSFAFDPVQKLLAIGDKSGYIRILGRPGVDAHA 84
            |.:.:.|::|::|    |..::|.:||||:.|::.|:||..||:|||..||.|::.|||||:.:.
Mosquito    11 QPSTERQKLQKEL----FAFRRTAQHGFPHKPSALAYDPKSKLMAIGTNSGVIKVFGRPGVEFYG 71

  Fly    85 KHEGES----ECAVLFAQFLVNEGALVTVTADDTIHLWSIRQKTPRIVQSLKF--QRERVTCIHL 143
            :|...|    :..|...:::...|.|:::||.:.:.||.........:::|.|  :.::::.:..
Mosquito    72 QHTSPSNNPADLIVQMLEWIPGTGRLLSLTASNQLVLWEPAGTLLVAIKNLAFDGKLKKISSLCC 136

  Fly   144 PVGSKWLYVGTEKGNIHVVHIDTFALSGYIINWNKAIEVVRTSH---PGAVIALCDNPLDANKLL 205
            ......:::|||.||::...:..|::...:|..:..:|.:.||:   |||:.::...|.:.|.||
Mosquito   137 SYMKDTVWIGTEGGNVYQFDVRNFSVKESVIYHDVVLEQLPTSYRLNPGAIESVKQLPNNHNLLL 201

  Fly   206 IAFECGLLVLWDLKAKCAELRWQA-----------AEAVKSLAWHYEGKYFVSSHTDGSICSWPT 259
            ||:..||.|||||:....:..:.:           |:......|:         |.|||..:|..
Mosquito   202 IAYNRGLAVLWDLETASVKQSFISPGHGQSVGLFIAQDATQFTWY---------HADGSFATWDL 257

  Fly   260 KPQAKPQSQ-VCPHAKINKDGNAEKCKPIYKVDLKSSATGETFTIFSGGMPSEKGSKSNCITVMV 323
            .....|::| ..|:       ..:.||.|.:: ::.........:||||||.....:..|::|..
Mosquito   258 DSPIPPENQKYVPY-------GPDPCKAIDRL-IRGHRGRCELVVFSGGMPRSAYGEHQCVSVHC 314

  Fly   324 GKATTV-LEMEHAVCDFITLCENPWPCETQEPYAIAVLLQYDLVLIDLLTPGFPCFESPYPMDLH 387
            ...|.| .:....|.||.....:..|   ::...:.|||:.:||..||.....|...:||...||
Mosquito   315 KDGTKVAFDFTSKVIDFFVTFNDVRP---EQAEVLVVLLEEELVAYDLTDETLPQINAPYLHSLH 376

  Fly   388 ESPVTCCTYLTDCPSDLVPAFYS----VGRTTTSKKSCFSEREWPISGG---------EWSPASC 439
            .|.|| |.:|.   |.:.|..|:    .|....::.||   :.||||||         |..|..
Mosquito   377 ASAVT-CNHLV---SQVSPEVYAKIKYAGEQQMAEYSC---KVWPISGGIVPNESVDDEEQPME- 433

  Fly   440 SYSEIVITGHQDGSLKFWDSGAGTLQILYKLKTAKMF--------------------EKPRSHVA 484
              .:::||||:|||:||||.....|..|..:|||.:|                    |.|.....
Mosquito   434 --RDVLITGHEDGSVKFWDCSDVCLTPLLHVKTAPLFNNSDDFESNLNASTEQLDDGEPPFRKAG 496

  Fly   485 HSHPESDNP-LAVHLIFLCSESRRLCVAGAMGQVMLFKFRKVESTSEVLVLEIPILYENFDDIYG 548
            ...|.||:| |||..:.||.::..|.:||..|.|::..|......:|......|:.....:.:
Mosquito   497 QFDPYSDDPRLAVKKVQLCPQTGTLVIAGTAGNVVMANFEASPQVAEETQSNGPLKMTTMNLV-- 559

  Fly   549 TSPECDFL-TGHQVQKAESSDSDKTAECSLKVRNGA------QRKPPGFQSQLVCLTTGPNRRNV 606
             |....|: .||...|.:.    :..|.:..:..|.      |..||                 .
Mosquito   560 -SDRDGFVWKGHDQLKVKR----QLLEENSPIIEGVNFLGVLQVLPP-----------------A 602

  Fly   607 QVTSLCISSSYGLMAYGTEYGLVIID------IIQKICLLSVACP-DLYGAHDPYSRTPKSPKRI 664
            .:|.:.:.|.:.|:|.||.:|||:.|      ::.| |.|:   | ||.||.:..||.....|.:
Mosquito   603 AITCIAMQSKWSLVAAGTAHGLVLFDYQNQAPVLHK-CTLN---PNDLTGAGETLSRRKSFKKTL 663

  Fly   665 ENKEEQSRSPSSDQLNDTTSPDSPSLEFVPEAGETSA---HDGVATAT-------SSRPSSPDPV 719
            .....:.|...|.:.|             |.||...|   |...|..|       .:||.. |.:
Mosquito   664 RESFRRLRKGRSTRNN-------------PNAGGAGAGGQHQQSAAETRPVERQIEARPVD-DGM 714

  Fly   720 VNSAR----------------ETLLSGS----------------AAATAAA-------AASAAVM 745
            .:..|                .||.||:                :||||||       :|..|..
Mosquito   715 GSMVRCLTFAQTFITNQNVYIPTLWSGTNSSTVSVFVLNLPPKQSAATAAAGENGADESAQTATA 779

  Fly   746 MAKSPQRDDAAPKELQDRRKS---------------------------------MSWKTFNLKRQ 777
            .::.|.......||:|.:.::                                 ..:|.|:|. |
Mosquito   780 TSRGPPVTGKLGKEIQMKHRAPIIGIAVVDSNGVPLEFQNVPGPAPHRVLIASEEQFKIFSLP-Q 843

  Fly   778 LSKVN---------MKIGGLNVNTDM-----ESLKNSSIFYTPKEV----SP-----EAATPPAT 819
            |..||         .::..:...|.|     .||.|||   .||.:    ||     :||.||.|
Mosquito   844 LKPVNKYKLTAHEGARVRRIAFATFMCTVPTSSLVNSS---PPKALVKPASPAAPAQQAADPPTT 905

  Fly   820 EEE----ATPEGKEDESLDDGEMA----------TNAGAAAAASPSPAVRGKFRSSTTDSPDEGA 870
            ..:    .|.....:.|:...::.          ||.|.....: .|.:|.:..|:.....|...
Mosquito   906 AADNNTSTTAVNDNNTSIVGSDVTTHYEISLLCLTNLGDCLVLT-VPELRRQLNSAAVRREDING 969

  Fly   871 SSSI-------------ASGIRRVDFEQPAGVEVERPNN-LPLADAPAPLKPARQKFKEKSRDQR 921
            .||:             :|.::|:..   :..::..||. :.:.|..||:..|..:...:.:||:
Mosquito   970 ISSLCFTSHGEALYMMSSSEVQRISL---SATKIVAPNGMIDVEDWSAPIDGASTEEDNEQQDQQ 1031

  Fly   922 ----LLSVPNIKYQPRDSRGG---ARNLKNDVSPLMGGGGGGGGVVGASS-GIGGSVAGGKKI-- 976
                :.:...::.:|.|:..|   |...:..||.....|.......|||: .:...||.|.:.
Mosquito  1032 AQETMQAEAALQQEPDDNASGSVAAAKSEQSVSREKVSGSATLLTNGASNPRLSNGVASGDEASP 1096

  Fly   977 HKLDGTFSRSRSS-SMSSI--DMSSSESVTCLAFIESYAKRNDILTLVPTLWIGTSFGSILTLFI 1038
            :|.:.|.:.|... ::.|:  .::|:.:..|....|....|.                |:|:...
Mosquito  1097 NKANETITSSIGDITIDSVRDHLNSTTTTLCSTTTEEIVGRL----------------SVLSTHT 1145

  Fly  1039 TMPERDVRKSQPVLITINGGPVVRLKGSITSMSFLDSYGSIIPYTFETWR--------DEKRDNK 1095
            |......:.|:  ::::|...:..||| |...:...|..:||.....|.:        :.|..||
Mosquito  1146 TQSSSTAKNSE--ILSMNSSNIGSLKG-IGETTEKTSNSAIIKSIITTVKHGSNATNGEAKESNK 1207

  Fly  1096 DRTPTKSSSRTS-------PTFTPTTANTL 1118
            ..|.|.:::.||       |...||||..|
Mosquito  1208 TSTITTTTTSTSVNGNDSVPPPLPTTAPPL 1237

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tomosyn	NP_727628.3	WD40	<41..257	CDD:441893	65/235 (28%)
		WD40 repeat	95..133	CDD:293791	7/37 (19%)
		WD40 repeat	138..184	CDD:293791	8/45 (18%)
		WD40 repeat	192..226	CDD:293791	13/33 (39%)
		LLGL	268..376	CDD:462446	26/109 (24%)
		R-SNARE_STXBP5_6	1403..1463	CDD:277226
l(2)gl	XP_313781.6	None