Protein Alignment Tomosyn and llgl1

DIOPT Version :10

• Sequence 1: NP_727628.3
• Gene: Tomosyn / 32217
• FlyBaseID: FBgn0030412
• Length: 1470
• Species: Drosophila melanogaster
• Sequence 2: XP_002935892.2
• Gene: llgl1 / 100486472
• XenbaseID: XB-GENE-868457
• Length: 1052
• Species: Xenopus tropicalis
• Alignment Length: 1533
• Identity: 321/1533 - (20%)
• Similarity: 541/1533 - (35%)
• Gaps: 573/1533 - (37%)

  Fly     1 MKKFTFKGVLDGFRQSVQPQATRQEQEIQEQLKADHFTLKKTFRHGFPYSPTSFAFDPVQKLLAI 65
            |.||.|:      ||...||        :|::|.:.|...||..||||..|:|.||||:.:::||
 Frog     1 MMKFRFR------RQGHDPQ--------REKIKQELFAFNKTVEHGFPNQPSSLAFDPLLRIMAI 51

  Fly    66 GDKSGYIRILGRPGVDAHAKHEGESECAVLFAQFLVNEGALVTVTADDTIHLWSIRQK--TPRIV 128
            |.|||.::|.|.|||:....|  :....|....||..:|.|:::..|:|:|||.::||  :..:.
 Frog    52 GAKSGAVKIYGAPGVEFTGLH--KDTATVTQMHFLPGQGRLLSLLDDNTMHLWELQQKDGSSHLE 114

  Fly   129 QSLKF---------------QRERVTCIHLPVGSKWLYVGTEKGNIHVVHIDTFALSGYIINWNK 178
            ::..|               ...|||.|.:....:...:|||.|.::.:.|.:..|..     .|
 Frog   115 ETRSFLLPGKPGFDCANSPPSFTRVTVILITASCEVAGLGTEGGGVYFIQIPSLKLLE-----EK 174

  Fly   179 AI---EVVRTSHP---------GAVIALCDNPLDANKLLIAFECGLLVLWDLKAKCAELRWQAAE 231
            .:   |:|: |.|         |.|.:|.::|.....:||.:..||:||||.:.:..|..:...:
 Frog   175 TLLQDEIVK-SLPEEYRCGKTLGPVESLQEHPCQRGTILIGYSRGLVVLWDQEGRKVEHLFLGNQ 238

  Fly   232 AVKSLAWHYEGKYFVSSHTDGSICSW----PTKPQAKPQSQVCPHAKINKDGNAEKCKPIYKVDL 292
            .::|:.|..:|..|:|||:||....|    .:...::|.:...|:...       .||.|.|:..
 Frog   239 QLESVFWGRKGTSFISSHSDGGYMVWEAASDSSTTSQPVTSKIPYGPF-------PCKAINKIQW 296

  Fly   293 KSSATGETFTIFSGGMPSEKGSKSNCITVMVGKATTVLEMEHAVCDFITLCENPWPCETQEPYAI 357
            :||::|..:.|||||||.......:|:|::.|:....|:....|.||.|:|......::..|.|:
 Frog   297 RSSSSGNPYIIFSGGMPRASYGDRHCVTILQGQNLVTLDFTSRVVDFFTVCPLKSEDDSDNPTAL 361

  Fly   358 AVLLQYDLVLIDLLTPGFPCFESPYPMDLHESPVTCCTYLTDCPSDLVPAFYSVGRTTTSKKSCF 422
            .||::.:||:|||.|||:|...:||...||.|.:||..::::..:.|.....|.|.....:   |
 Frog   362 VVLVEEELVVIDLQTPGWPTVPTPYLAPLHSSAITCAYHISNVTTKLWERIISAGEQQNPQ---F 423

  Fly   423 SEREWPISGGEWSPASCSYSEIVITGHQDGSLKFWDSGAGTLQILYKLKTAKMFEKPRSH----- 482
            |...|||.||.......:...:::|||:||:::|||:....|:.||||.||.:|:....|
 Frog   424 SSVNWPIDGGRNLAEEPAQRGLLLTGHEDGTVRFWDASGVALRPLYKLSTAGIFQTDCDHNESFN 488

  Fly   483 ------------VAHSHPESDNP-LAVHLIFLCSESRRLCVAGAMGQVMLFKF--RKVESTSEVL 532
                        |....|.||:| |.:..|.||..|.::.|||..|||::...  .|||.|..|.
 Frog   489 QSNDEEWPPFRKVGCFDPYSDDPRLGIQKIALCKYSGKMLVAGTAGQVLVMDLNDEKVEHTINVA 553

  Fly   533 VLEIPILYENFDDIYGTSPECDFLTGHQVQKAESSDSDKTAECSLKVRNGAQRKPPGFQSQLVCL 597
            .:::....|.|.           ..||.               .|..|||:....||||:..:..
 Frog   554 TVDLLQEREGFT-----------WKGHD---------------RLTPRNGSLFFQPGFQTITLVQ 592

  Fly   598 TTGPNRRNVQVTSLCISSSYGLMAYGTEYGLVIIDIIQKICLLSVACPDLYGAHDPYSRTPKSPK 662
            ...|    ..||::.:.|.:.|:|:||.:|                    :|..|.:.|:|...:
 Frog   593 CMPP----AAVTAVALHSEWNLVAFGTSHG--------------------FGLFDYHRRSPVLAR 633

  Fly   663 RIENKEEQSRSPSSDQLNDTTSP-DSPSLEFVPEAGETSAHDGVATATSSRPSSPDPVVNSARET 726
                              .|..| ||.::|                       .|...|.|.:::
 Frog   634 ------------------CTLHPNDSLAME-----------------------GPLSRVKSLKKS 657

  Fly   727 LLSGSAAATAAAAASAAVMMAKSPQRDDAAPKELQDRRKSMSWKTFNLKRQLSKVNMKIGGLNVN 791
            |                                    |:|.        |::.|  .::.|
 Frog   658 L------------------------------------RQSF--------RRIRK--SRVSG---- 672

  Fly   792 TDMESLKNSSIFYTPKEVSPEAATPPATEEEATPEGKEDESLDDGEMATNAGAAAAASPSPAVRG 856
                            :..|...:||:..:||           :.::|..||
 Frog   673 ----------------KKRPNTGSPPSRLQEA-----------NAQLAEQAG------------- 697

  Fly   857 KFRSSTTDSPDEGASSSIASGIRRVDFEQPAGVEVERPNNLPLADAPAPLKPARQKFKEKSRDQR 921
                                                 |::|.:|       |.:::.:.:|.|..
 Frog   698 -------------------------------------PHDLDIA-------PVQRRIEPRSADDS 718

  Fly   922 LLSVPNIKYQPRDSRGGARNLKNDVSPLMGGGGGGGGVVGASSGIGGSVAGGKKIHKLDGTFSRS 986
            |                                         ||:
 Frog   719 L-----------------------------------------SGV-------------------- 722

  Fly   987 RSSSMSSIDMSSSESVTCLAFIESYAKRNDILTLVPTLWIGTSFGSILTLFITMPERDV---RKS 1048
                           |.||.|.:::.:  |.:...||:|.||:.||:....:.:|.|:.   |.:
 Frog   723 ---------------VRCLYFADTFLR--DAIHHGPTMWAGTNSGSVFAYALEVPSREKLSDRSA 770

  Fly  1049 QPVLITINGGPVVRL--KGSITSMSFLDSYGSIIPYTFETWRDEKRDNKDRTPTKSSSRTSPTFT 1111
            :.||     |..::|  :..:.|::.||..|:.:|..||
 Frog   771 EAVL-----GKEIQLMHRAPVVSIAVLDGRGNPLPEPFE-------------------------- 804

  Fly  1112 PTTANTLSNTSVAGGASAGGGAGGGGGAGGGAASGGAAAGGPAGGGAGAGSAAGAAGGVGSGVTS 1176
                                                                             
 Frog   805 ----------------------------------------------------------------- 804

  Fly  1177 GGGMSSSSASSSGISGSVSTGLETLTDRQYIVIASEKQTKVFDV------------ANQ-CCINR 1228
               :|...|.:..:.|:.|           ::|:||:|.|||.:            |:: |.:.:
 Frog   805 ---VSQDLAKAPDMQGTHS-----------VLISSEEQFKVFTLPKVSAKTKFKLTAHEGCRVRK 855

  Fly  1229 IQLSEMDFAVKAETITMKDGS--CLATYLSNGHLMVHSLPSLKLLLDTDFLPLMELSFQTKCKQG 1291
            :.|:....|      |..|.|  |||...:.|.:.|.::|.|:..:..|.:...::|....|
 Frog   856 VALATFTSA------TSDDYSENCLACLTNLGDIHVFTVPGLRPQVRYDCIRKEDISGIASC--- 911

  Fly  1292 IVDPMLSIWGQQIIVHEDTTQISKIFCFSHKGHGLYMASPTEIQKFTISSE-----FCQFILEMM 1351
                                      .|:..|.|.|:.||:|.::|::|::     .|....:..
 Frog   912 --------------------------VFTKYGQGFYLISPSEFERFSLSAKNITEPVCLVEFDRP 950

  Fly  1352 GE-LYTVHEMPEQPKEGFFKGLFGGGAKLLDREELFGEQSGKPN--RSVARHIPGPNLEQLGQRA 1413
            .: |:..::|...|     ||....|..:| |:....:|:.:.|  ..:|...|.|    |....
 Frog   951 HDPLHFSNKMTPSP-----KGNQANGTHIL-RDSEASQQATEGNGCERMAEFSPSP----LDSPM 1005

  Fly  1414 STAASEISRAHQLAMER-GEKLNLLEERAERMANTAQD 1450
            ::..:.:.....:.:|. .:.|...||..:.|.|:|.|
 Frog  1006 NSMDTTLDTTGDITVEDVRDILGSTEEAEKNMKNSADD 1043

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tomosyn	NP_727628.3	WD40	<41..257	CDD:441893	74/244 (30%)
		WD40 repeat	95..133	CDD:293791	11/39 (28%)
		WD40 repeat	138..184	CDD:293791	11/48 (23%)
		WD40 repeat	192..226	CDD:293791	11/33 (33%)
		LLGL	268..376	CDD:462446	36/107 (34%)
		R-SNARE_STXBP5_6	1403..1463	CDD:277226	10/49 (20%)
llgl1	XP_002935892.2	WD40	31..>268	CDD:441893	73/244 (30%)
		WD40 repeat	37..69	CDD:293791	17/31 (55%)
		WD40 repeat	78..116	CDD:293791	12/37 (32%)
		LLGL	279..380	CDD:462446	36/107 (34%)