DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11085 and LHX2

DIOPT Version :9

Sequence 1:	NP_572815.3	Gene:	CG11085 / 32213	FlyBaseID:	FBgn0030408	Length:	295	Species:	Drosophila melanogaster
Sequence 2:	NP_004780.3	Gene:	LHX2 / 9355	HGNCID:	6594	Length:	406	Species:	Homo sapiens

Alignment Length:	235	Identity:	60/235 - (25%)
Similarity:	96/235 - (40%)	Gaps:	41/235 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 QELLLSHHHRRFTHHDESSVESCLSATRGPGSGTGSGGGGGGG-----GGGGVASGLSAAAAAAG 111
            :.||...:...|.|.|.::..:..:|.:  .:|.|:.|....|     |.|.|..|......:.|
Human   170 EALLQGEYPAHFNHADVAAAAAAAAAAK--SAGLGAAGANPLGLPYYNGVGTVQKGRPRKRKSPG 232

  Fly   112 VAAGLLAAAASGANGDRDANGGSGPGSGGGTSGGYAEH--KLQLSKSGRKPRRRRTAFTHAQLAY 174
            ..|.|.|..|:.:..:.|                 |||  :.|...|.:|.:|.||:|.|.||..
Human   233 PGADLAAYNAALSCNEND-----------------AEHLDRDQPYPSSQKTKRMRTSFKHHQLRT 280

  Fly   175 LERKFRCQKYLSVADRSDVAETLNLSETQVKTWYQNRRTKWKRQNQLRLEQLRHQATMEK--DFV 237
            ::..|.........|...:|:...|::..::.|:||.|.|::| |.||.|    ...::|  |..
Human   281 MKSYFAINHNPDAKDLKQLAQKTGLTKRVLQVWFQNARAKFRR-NLLRQE----NTGVDKSTDAA 340

  Fly   238 VQDGGGAGGLGCCPSGLSSSFSAAAAAAAAASNPCNFLTS 277
            :|.|        .|||.:|..|.|:.:.::.......|||
Human   341 LQTG--------TPSGPASELSNASLSPSSTPTTLTDLTS 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11085	NP_572815.3	Homeobox	163..216	CDD:278475	15/52 (29%)
LHX2	NP_004780.3	LIM1_Lhx2	43..106	CDD:188853
		LIM2_Lhx2_Lhx9	111..169	CDD:188763
		COG5576	<247..378	CDD:227863	41/156 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..270		8/36 (22%)
		Homeobox	270..323	CDD:395001	15/52 (29%)
		Nuclear localization signal. /evidence=ECO:0000255	307..323		5/15 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..374		14/57 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..406
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910