DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11085 and pax6b

DIOPT Version :9

Sequence 1:	NP_572815.3	Gene:	CG11085 / 32213	FlyBaseID:	FBgn0030408	Length:	295	Species:	Drosophila melanogaster
Sequence 2:	XP_005168876.1	Gene:	pax6b / 60639	ZFINID:	ZDB-GENE-001031-1	Length:	450	Species:	Danio rerio

Alignment Length:	347	Identity:	84/347 - (24%)
Similarity:	127/347 - (36%)	Gaps:	118/347 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LSNDDSDID------IEDRSTPDSTAAGCQQELLLSHHHRR-------FTHHDESSVE------- 72
            :.|..|.::      :..|..||||.   |:.:.|:|...|       ...||::.|:
Zfish    20 MQNSHSGVNQLGGVFVNGRPLPDSTR---QKIVELAHSGARPCDISRILQTHDDAKVQLDNKNVS 81

  Fly    73 -SCLSATRGPGSGTGSGGGGGGGGG----------GGVAS-----------GLSAAAAAAGVAAG 115
             .|:|...|....|||......||.          |.:|.           .:.....:.||...
Zfish    82 NGCVSKILGRYYETGSIRPRAIGGSKPRVATPEVVGKIAQYKRECPSIFAWEIRDRLLSEGVCTN 146

  Fly   116 -----------LLAAAAS-----GANGDRD----ANGGSG-----PGSGGGTS------------ 143
                       :|...||     ||:|..|    .||.||     ||...|||
Zfish   147 DNIPSVSSINRVLRNLASEKQQMGADGMYDKLRMLNGQSGTWGTRPGWYPGTSVPGQPNQDGCQQ 211

  Fly   144 ---GGYAEHKLQLSKSG-------------RKPRRRRTAFTHAQLAYLERKFRCQKYLSVADRSD 192
               ||  |:...:|.:|             ||.:|.||:||..|:..||::|....|..|..|..
Zfish   212 QDNGG--ENTNSISSNGEDSDETQMRLQLKRKLQRNRTSFTQEQIEALEKEFERTHYPDVFARER 274

  Fly   193 VAETLNLSETQVKTWYQNRRTKWKRQNQLRLEQLRHQATMEKDFVVQDGGGAGGLGCCPSGLSSS 257
            :|..::|.|.:::.|:.|||.||:|:.:||.:  |.||:.....:               .:|||
Zfish   275 LAAKIDLPEARIQVWFSNRRAKWRREEKLRNQ--RRQASNSSSHI---------------PISSS 322

  Fly   258 FSAAA-AAAAAASNPCNFLTSA 278
            |:.:. .|....:.|.:|.|.:
Zfish   323 FNTSVYQAIPQPTTPVSFTTGS 344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11085	NP_572815.3	Homeobox	163..216	CDD:278475	19/52 (37%)
pax6b	XP_005168876.1	PAX	23..160	CDD:128645	25/139 (18%)
pax6b	XP_005168876.1	Homeobox	246..298	CDD:306543	19/51 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910