DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11085 and LMX1A

DIOPT Version :9

Sequence 1:	NP_572815.3	Gene:	CG11085 / 32213	FlyBaseID:	FBgn0030408	Length:	295	Species:	Drosophila melanogaster
Sequence 2:	NP_001167540.1	Gene:	LMX1A / 4009	HGNCID:	6653	Length:	382	Species:	Homo sapiens

Alignment Length:	152	Identity:	44/152 - (28%)
Similarity:	68/152 - (44%)	Gaps:	29/152 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 AAAASGANGDRDANGGSGPGSGGGTSGGYAEHKLQLSKSGRKPRRRRTAFTHAQLAYLERKFR-- 180
            ||:.||.:.|.::...|..|:|.||:....:||        :|:|.||..|..|....:..|.
Human   161 AASDSGKSDDEESLCKSAHGAGKGTAEEGKDHK--------RPKRPRTILTTQQRRAFKASFEVS 217

  Fly   181 ---CQKYLSVADRSDVAETLNLSETQVKTWYQNRRTKWK----RQNQLRLEQLRHQATMEKDFVV 238
               |:|.     |..:|....||...|:.|:||:|.|.|    ||.|.:.:|   |.|.......
Human   218 SKPCRKV-----RETLAAETGLSVRVVQVWFQNQRAKMKKLARRQQQQQQDQ---QNTQRLSSAQ 274

  Fly   239 QDGGGAGGLGCCPSGLSSSFSA 260
            .:|||:.|:    .|:.:.::|
Human   275 TNGGGSAGM----EGIMNPYTA 292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11085	NP_572815.3	Homeobox	163..216	CDD:278475	17/57 (30%)
LMX1A	NP_001167540.1	LIM1_Lmx1a	35..86	CDD:188756
		LIM2_Lmx1a_Lmx1b	94..148	CDD:188764
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	161..208		18/54 (33%)
		Homeobox	198..252	CDD:395001	17/58 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	252..285		10/39 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910