DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11085 and PDX1

DIOPT Version :9

Sequence 1:	NP_572815.3	Gene:	CG11085 / 32213	FlyBaseID:	FBgn0030408	Length:	295	Species:	Drosophila melanogaster
Sequence 2:	NP_000200.1	Gene:	PDX1 / 3651	HGNCID:	6107	Length:	283	Species:	Homo sapiens

Alignment Length:	171	Identity:	52/171 - (30%)
Similarity:	73/171 - (42%)	Gaps:	44/171 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 ANGGSGPGSGGGTSGGYAEHKLQLSKSGRKPRRRRTAFTHAQLAYLERKFRCQKYLSVADRSDVA 194
            |:...|..:||..:....|:|           |.|||:|.|||..||::|...||:|...|.::|
Human   127 AHAWKGQWAGGAYAAEPEENK-----------RTRTAYTRAQLLELEKEFLFNKYISRPRRVELA 180

  Fly   195 ETLNLSETQVKTWYQNRRTKWKRQNQLRLEQLRHQATM---------EKDFVVQDG--------- 241
            ..|||:|..:|.|:||||.|||::.    ::.|...|.         |:|..|..|
Human   181 VMLNLTERHIKIWFQNRRMKWKKEE----DKKRGGGTAVGGGGVAEPEQDCAVTSGEELLALPPP 241

  Fly   242 ---GG--------AGGLGCCPSGLSSSFSAAAAAAAAASNP 271
               ||        |...|..|.|||:|...::.|......|
Human   242 PPPGGAVPPAAPVAAREGRLPPGLSASPQPSSVAPRRPQEP 282

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11085	NP_572815.3	Homeobox	163..216	CDD:278475	26/52 (50%)
PDX1	NP_000200.1	Transactivation domain. /evidence=ECO:0000250	13..73
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	34..71
		Antp-type hexapeptide	118..123
		Homeobox	149..202	CDD:278475	26/52 (50%)
		Nuclear localization signal. /evidence=ECO:0000250	197..203		4/5 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	201..283		19/86 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910