DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11085 and UNCX

DIOPT Version :9

Sequence 1:	NP_572815.3	Gene:	CG11085 / 32213	FlyBaseID:	FBgn0030408	Length:	295	Species:	Drosophila melanogaster
Sequence 2:	NP_001073930.1	Gene:	UNCX / 340260	HGNCID:	33194	Length:	531	Species:	Homo sapiens

Alignment Length:	199	Identity:	58/199 - (29%)
Similarity:	73/199 - (36%)	Gaps:	68/199 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 LLSHHHRRFTHHDESSVESCLSATRGPGSGTGSGGGGGGGGGGGVAS----------------GL 103
            ||.|.|.:|                             ||..|||..                .|
Human     6 LLEHPHAQF-----------------------------GGSLGGVVGFPYPLGHHHVYELAGHQL 41

  Fly   104 SAAAAAA-------GVAAGLLAAAASGANGDRDANGGSGPGSGGGTSGGYAEHKLQLSKSGR--- 158
            .:|||||       |:..|..|||||..|.........|.|..|        ...:||.||.
Human    42 QSAAAAASVPFSIDGLLGGSCAAAASVVNPTPLLPAACGVGGDG--------QPFKLSDSGDPDK 98

  Fly   159 -----KPRRRRTAFTHAQLAYLERKFRCQKYLSVADRSDVAETLNLSETQVKTWYQNRRTKWKRQ 218
                 |.||.||.||..||..||:.|....|..|..|..:|..|:|.|::|:.|:||||.||:::
Human    99 ESPGCKRRRTRTNFTGWQLEELEKAFNESHYPDVFMREALALRLDLVESRVQVWFQNRRAKWRKK 163

  Fly   219 NQLR 222
            ...:
Human   164 ENTK 167

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11085	NP_572815.3	Homeobox	163..216	CDD:278475	23/52 (44%)
UNCX	NP_001073930.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	87..107		5/19 (26%)
		Homeobox	108..161	CDD:306543	23/52 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	161..312		0/7 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	324..344
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	401..531
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910