DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11085 and pax6a

DIOPT Version :9

Sequence 1:	NP_572815.3	Gene:	CG11085 / 32213	FlyBaseID:	FBgn0030408	Length:	295	Species:	Drosophila melanogaster
Sequence 2:	XP_009296153.1	Gene:	pax6a / 30567	ZFINID:	ZDB-GENE-990415-200	Length:	459	Species:	Danio rerio

Alignment Length:	348	Identity:	82/348 - (23%)
Similarity:	127/348 - (36%)	Gaps:	113/348 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 QSSKSFLIRDLLGDLINRRQTDSELELSNDDSDIDIEDRSTPDSTAAGCQQELLLSHHHRR---- 62
            :|..:.::::.:.|:.|...:.     .|....:.:..|..||||.   |:.:.|:|...|
Zfish    13 ESGVASMMQNKVYDICNEGHSG-----VNQLGGVFVNGRPLPDSTR---QKIVELAHSGARPCDI 69

  Fly    63 ----FTHHD--------ESSVESCLSATRGPGSGTGSGGGGGGGGG----------GGVAS---- 101
                .||.|        |:....|:|...|....|||......||.          |.:|.
Zfish    70 SRILQTHADAKVQVLDNENVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATPEVVGKIAQYKRE 134

  Fly   102 -------GLSAAAAAAGVAAG-----------LLAAAAS-----GANGD----RDANG-----GS 134
                   .:.....:.||...           :|...||     ||:|.    |..||     |:
Zfish   135 CPSIFAWEIRDRLLSEGVCTNDNIPSVSSINRVLRNLASEKQQMGADGMYEKLRMLNGQTGTWGT 199

  Fly   135 GPGSGGGT-------------SGGYAEHKLQLSKSG-------------RKPRRRRTAFTHAQLA 173
            .||...||             |.|..|:...:|.:|             ||.:|.||:||..|:.
Zfish   200 RPGWYPGTSVPGQPNQDGCQQSDGGGENTNSISSNGEDSDETQMRLQLKRKLQRNRTSFTQEQIE 264

  Fly   174 YLERKFRCQKYLSVADRSDVAETLNLSETQVKTWYQNRRTKWKRQNQLRLEQLRHQATMEKDFVV 238
            .||::|....|..|..|..:|..::|.|.:::.|:.|||.||:|:.:||.:  |.||:.....:
Zfish   265 ALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRREEKLRNQ--RRQASNSSSHI- 326

  Fly   239 QDGGGAGGLGCCPSGLSSSFSAA 261
                          .:|||||.:
Zfish   327 --------------PISSSFSTS 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11085	NP_572815.3	Homeobox	163..216	CDD:278475	19/52 (37%)
pax6a	XP_009296153.1	PAX	31..169	CDD:128645	26/145 (18%)
		Homeobox	255..307	CDD:306543	19/51 (37%)
		Retinal	341..>459	CDD:330657
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910