DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11085 and rx3

DIOPT Version :9

Sequence 1:	NP_572815.3	Gene:	CG11085 / 32213	FlyBaseID:	FBgn0030408	Length:	295	Species:	Drosophila melanogaster
Sequence 2:	NP_571302.1	Gene:	rx3 / 30474	ZFINID:	ZDB-GENE-990415-238	Length:	292	Species:	Danio rerio

Alignment Length:	281	Identity:	76/281 - (27%)
Similarity:	112/281 - (39%)	Gaps:	61/281 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 DIEDRSTPDS---TAAGCQQELLLSHHHRRFTHHDESSVESCLSATRG-----PGSGTGSGGGGG 92
            |:|||.:|.:   .:.|.|..:              .|:||.| ..:|     |....|||..|.
Zfish    10 DMEDRLSPSARLVRSPGSQTRI--------------HSIESIL-GFKGETLFHPAFPYGSGKTGK 59

  Fly    93 GGGGGGVASGLSAAAAAAGVAAGLLAAAASGANGDRDANGGSGPGSGGGTSGGYAEHKLQLSKSG 157
            .      ...||....:.....|:..:....:....||:||                ||...::.
Zfish    60 D------TEHLSPKKDSNKHFDGVCRSTVMVSPDLPDADGG----------------KLSDDENP 102

  Fly   158 RKP-RRRRTAFTHAQLAYLERKFRCQKYLSVADRSDVAETLNLSETQVKTWYQNRRTKWKRQNQL 221
            :|. ||.||.||..||..|||.|....|..|..|.::|..:||.|.:|:.|:||||.||:||.:|
Zfish   103 KKKHRRNRTTFTTFQLHELERAFEKSHYPDVYSREELALKVNLPEVRVQVWFQNRRAKWRRQEKL 167

  Fly   222 RLEQLRHQ----ATMEKDFVVQDGGG-------AGGLGCCPSGLSS--SFSAAAAAAAAASNPCN 273
            .:..::.|    .::.:...:..|.|       .|.:....|.|.|  ||.....|..|:..|..
Zfish   168 EVSSIKLQESSMLSIPRSGPLSLGSGLPLEPWLTGPISTSSSPLQSLPSFITPQQAVPASYTPPQ 232

  Fly   274 FLTSAAAAAIFRNVGYVHGCP 294
            ||:|:.......::|.|  ||
Zfish   233 FLSSSTLNHSLPHIGAV--CP 251

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11085	NP_572815.3	Homeobox	163..216	CDD:278475	24/52 (46%)
rx3	NP_571302.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27		5/16 (31%)
		Octapeptide motif	32..39		4/7 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	53..72		6/24 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	85..107		7/37 (19%)
		Homeobox	110..162	CDD:278475	24/51 (47%)
		OAR	268..284	CDD:281777
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	272..285
		Nuclear localization signal. /evidence=ECO:0000255	278..282
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910