DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11085 and RAX

DIOPT Version :9

Sequence 1:	NP_572815.3	Gene:	CG11085 / 32213	FlyBaseID:	FBgn0030408	Length:	295	Species:	Drosophila melanogaster
Sequence 2:	NP_038463.2	Gene:	RAX / 30062	HGNCID:	18662	Length:	346	Species:	Homo sapiens

Alignment Length:	232	Identity:	65/232 - (28%)
Similarity:	87/232 - (37%)	Gaps:	69/232 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 PGSGTGSGGGGGGGGG------GGVASGLSAAAAAAGVAA--GLLAA--AASGANG--DRDANGG 133
            ||.......|.....|      ||..|.|.:..|..|...  |:|..  |..||.|  :||...|
Human     4 PGCAPAMADGSFSLAGHLLRSPGGSTSRLHSIEAILGFTKDDGILGTFPAERGARGAKERDRRLG 68

  Fly   134 SGP--------GS------------------------------GGGTSGGYAEHKLQLSKS---G 157
            :.|        ||                              ..|...|.|..:.:||:.   .
Human    69 ARPACPKAPEEGSEPSPPPAPAPAPEYEAPRPYCPKEPGEARPSPGLPVGPATGEAKLSEEEQPK 133

  Fly   158 RKPRRRRTAFTHAQLAYLERKFRCQKYLSVADRSDVAETLNLSETQVKTWYQNRRTKWKRQNQLR 222
            :|.||.||.||..||..|||.|....|..|..|.::|..:||.|.:|:.|:||||.||:||.:|.
Human   134 KKHRRNRTTFTTYQLHELERAFEKSHYPDVYSREELAGKVNLPEVRVQVWFQNRRAKWRRQEKLE 198

  Fly   223 LEQLRHQ-------------ATMEKDFVVQDGGGAGG 246
            :..::.|             ||:..   :..|.|:||
Human   199 VSSMKLQDSPLLSFSRSPPSATLSP---LGAGPGSGG 232

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11085	NP_572815.3	Homeobox	163..216	CDD:278475	24/52 (46%)
RAX	NP_038463.2	Octapeptide motif	33..40		1/6 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	46..145		23/98 (23%)
		Homeobox	140..192	CDD:278475	24/51 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	194..318		9/42 (21%)
		OAR	319..335	CDD:281777
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	323..336
		Nuclear localization signal. /evidence=ECO:0000255	329..333
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910