DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11085 and DLX5

DIOPT Version :9

Sequence 1:	NP_572815.3	Gene:	CG11085 / 32213	FlyBaseID:	FBgn0030408	Length:	295	Species:	Drosophila melanogaster
Sequence 2:	NP_005212.1	Gene:	DLX5 / 1749	HGNCID:	2918	Length:	289	Species:	Homo sapiens

Alignment Length:	244	Identity:	54/244 - (22%)
Similarity:	95/244 - (38%)	Gaps:	88/244 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 GGVASG-LSAAAAAAGVAAGLLAAAASGANGDRDANGGSGPGSGGGTSGGYAEHKL--------- 151
            ||...| .|..:|:.|.|.........|.||    :.||.|..      .||::..
Human    52 GGAPHGYCSPTSASYGKALNPYQYQYHGVNG----SAGSYPAK------AYADYSYASSYHQYGG 106

  Fly   152 ----------------------QLSKSGRKPRRRRTAFTHAQLAYLERKFRCQKYLSVADRSDVA 194
                                  .::...:|.|:.||.::..|||.|:|:|:..:||::.:|:::|
Human   107 AYNRVPSATNQPEKEVTEPEVRMVNGKPKKVRKPRTIYSSFQLAALQRRFQKTQYLALPERAELA 171

  Fly   195 ETLNLSETQVKTWYQNRRTKWKRQNQLRLEQLRHQATMEKDFVVQDG--------GGAGGLGCC- 250
            .:|.|::||||.|:||:|:|.|:                   ::::|        ..:..:.|.
Human   172 ASLGLTQTQVKIWFQNKRSKIKK-------------------IMKNGEMPPEHSPSSSDPMACNS 217

  Fly   251 --------PSGLSSSF----------SAAAAAAAAASNPCNFLTSAAAA 281
                    |.|.|.|.          |..:.|::...|..::.||||::
Human   218 PQSPAVWEPQGSSRSLSHHPHAHPPTSNQSPASSYLENSASWYTSAASS 266

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11085	NP_572815.3	Homeobox	163..216	CDD:278475	23/52 (44%)
DLX5	NP_005212.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..49
		DLL_N	32..118	CDD:315147	15/75 (20%)
		Homeobox	140..193	CDD:306543	23/52 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	198..251		8/52 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	270..289
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910