DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fpgs and FOL3

DIOPT Version :9

Sequence 1:	NP_572814.1	Gene:	Fpgs / 32212	FlyBaseID:	FBgn0030407	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_013831.1	Gene:	FOL3 / 855140	SGDID:	S000004719	Length:	427	Species:	Saccharomyces cerevisiae

Alignment Length:	453	Identity:	112/453 - (24%)
Similarity:	179/453 - (39%)	Gaps:	77/453 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 KYLERSGLPLETVEQLSFIHVAGTKGKGSTCALTESLLRHQGFRTGFFSSPHILFTNERIRIDGQ 194
            |.||..|.|..:   |..:|:|||.||||.|....|:|:.:.::.|.|::||::...:.|.|:.:
Yeast    12 KLLEHLGNPQNS---LRVLHIAGTNGKGSVCTYLSSVLQQKSYQIGKFTTPHLVHVTDSITINNK 73

  Fly   195 LLSKDKFTEQFWKVYNRLWDLREHDHDMPAYFKFLTILGFHVFVAENVDVVVLEVGIGGEHDCTN 259
            .:.    .|::..:..:|..|.:........|:.||...|..|........|:|||:||..|.||
Yeast    74 PIP----LERYQNIRLQLEALNKSHSLKCTEFELLTCTAFKYFYDVQCQWCVIEVGLGGRLDATN 134

  Fly   260 IV--RNVRTVGITSLGLEHTELLGRTLPEIAWQKAGIIKTG--SHVFTHVTQPECLEVIRQRTKE 320
            ::  .|....|||.:.|:|...||.||.||:.:|||||..|  ..|.....:...:.|:::|.|
Yeast   135 VIPGANKACCGITKISLDHESFLGNTLSEISKEKAGIITEGVPFTVIDGTNEASVINVVKERCK- 198

  Fly   321 HSATLYEVPPTEDYFRSKAY-APIWQTFS-NLIRLNG-----SLAIQLAQ-DWLSQSGKQQHTPN 377
              |...|:..|:........ ...|..|. ..:.|||     :|.:.:.. |:|..:.....|.|
Yeast   199 --ALGSELSVTDSQLNGNMIDTNSWGCFDLAKLPLNGEYQIFNLRVAMGMLDYLQMNELIDITKN 261

  Fly   378 EVKMDPQLLDGLISTHWPGRCQLIEW-------HGMRLHLDGAHTLESMEVCTDWFEKNVRDSVN 435
            ||.      ..|....||||...:::       ..:.:.:||||...:......:..|...:  .
Yeast   262 EVS------TRLAKVDWPGRLYRMDYRFDKVSNRTVPILMDGAHNGSAAVELVKYLRKEYGN--Q 318

  Fly   436 PKILIFNRTGESGFAPLLKLLNRTCDFDMVCFVPNLATSTPNAPSQVMVRFSPEMQLNRARIIAS 500
            |...:...|......|||:.|.|..|                  ..::.||:        .:...
Yeast   319 PLTFVMAVTHGKNLEPLLQPLLRPID------------------QVILTRFN--------NVEGM 357

  Fly   501 AWSDLCATEQKKDVGQVYNTLTDAFTA-------IRQRFPQA--TDNEGQLEVLVTGSIHLLG 554
            .|......|:.||.     .||..:|.       :.|..|..  ..:|.:..::|.||::|.|
Yeast   358 PWIHATDPEEIKDF-----ILTQGYTKEIVIENDLHQVLPSLAHVSDEQRRPIVVCGSLYLCG 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fpgs	NP_572814.1	PLN02881	90..554	CDD:215476	111/451 (25%)
FOL3	NP_013831.1	FolC	3..427	CDD:223362	112/453 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346397
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0285
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1575
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001698
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100496
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.590