DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fpgs and fpgs

DIOPT Version :9

Sequence 1:	NP_572814.1	Gene:	Fpgs / 32212	FlyBaseID:	FBgn0030407	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_998602.2	Gene:	fpgs / 406746	ZFINID:	ZDB-GENE-040426-2781	Length:	572	Species:	Danio rerio

Alignment Length:	533	Identity:	204/533 - (38%)
Similarity:	293/533 - (54%)	Gaps:	79/533 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 FELAIKQLNSLQSNDAA---IRNSMSNSRVDTKADTIKYLERSGLPLETVEQLSFIHVAGTKGKG 157
            ::.|:..||:||:|.:|   ::....:.::..:| ...:|:|:||.:|.:::|:.|||.||||||
Zfish    47 YQDAVCTLNTLQTNASALEQVKRERGHPQLQLQA-MRGFLQRAGLKVEELDRLNIIHVTGTKGKG 110

  Fly   158 STCALTESLLRHQGFRTGFFSSPHILFTNERIRIDGQLLSKDKFTEQFWKVYNRLWDLRE-HDHD 221
            ||||.||.:||:.||||||:||||::...|||||:||.:.|:.||:.||:||.||.:.:: |...
Zfish   111 STCAFTEKILRNYGFRTGFYSSPHLVQVRERIRINGQPIGKELFTKYFWQVYGRLEETKDAHGGS 175

  Fly   222 MPAYFKFLTILGFHVFVAENVDVVVLEVGIGGEHDCTNIVRNVRTVGITSLGLEHTELLGRTLPE 286
            |||||:|||||.||||:.|.||:.|:||||||.:|||||:|.....||:|||::||.:||.|:.:
Zfish   176 MPAYFRFLTILAFHVFLQEKVDLAVIEVGIGGAYDCTNIIRRPWVCGISSLGIDHTSILGDTIEK 240

  Fly   287 IAWQKAGIIKTGSHVFTHVTQPE-CLEVIRQRTKEHSATLYEVPPTEDYFRSKAYAPIWQTFSNL 350
            |||||.||.|.|...|| |.||: .::|:::|.:|...:| .|.|..|.:.|:....:.....:.
Zfish   241 IAWQKGGIFKPGVPAFT-VKQPDGPMKVLQERAEEVGCSL-SVCPDLDEYESEGSLSLGLAGQHQ 303

  Fly   351 IRLNGSLAIQLAQDWLSQSGKQQH------TPNE---------VKMDPQLLDGLISTHWPGRCQL 400
             |.|.|||:||:..||     |:|      :|.|         .:..|.::.||..|.||||.|.
Zfish   304 -RSNASLALQLSHTWL-----QRHILTDPASPVEFSGVSSAPAFQPSPAMIKGLAETEWPGRNQT 362

  Fly   401 IEWHGMRLHLDGAHTLESMEVCTDWF-------EKNVRDSVNPKILIFNRTGESGFAPLLKLLNR 458
            ::...:..::|||||..||:.|..||       |:|...|| .::|:||.|||...|.:|||| .
Zfish   363 LKHGPVTYYMDGAHTTRSMQACVRWFNEVATQHERNAGGSV-LRVLLFNATGERDCAAMLKLL-A 425

  Fly   459 TCDFDMVCFVPNL--ATSTPNAPSQVMVRFSPEMQLNRARIIASAWSDLCATEQKKD----VG-- 515
            .|.||...|.||:  |.::.||..| ....|.|..|.|......:|..|...|:|.:    :|
Zfish   426 PCHFDFAVFCPNITEAIASCNADQQ-NFNVSVENMLTRCLDNQQSWRVLNGHEEKPEAELLIGGG 489

  Fly   516 -----------QVYNTLTDAFTAIRQ--------------------RFPQATDNEGQ-LEVLVTG 548
                       .|:..:..|...|.|                    ....|...|.| :.||:||
Zfish   490 LPLVAERHGDTLVFPCILSALQWISQGRDSVLADANKHTIPVKPSINAKAAPLREAQNIHVLITG 554

  Fly   549 SIHLLGAAISALD 561
            |:||:|.|:..||
Zfish   555 SLHLVGGALKHLD 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fpgs	NP_572814.1	PLN02881	90..554	CDD:215476	200/524 (38%)
fpgs	NP_998602.2	PLN02881	47..566	CDD:215476	202/530 (38%)
fpgs	NP_998602.2	Mur_ligase_C	356..437	CDD:280948	34/82 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595613
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0285
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6997
Inparanoid	1	1.050	304	1.000	Inparanoid score	I2638
OMA	1	1.010	-	-		QHG51906
OrthoDB	1	1.010	-	-		D231485at33208
OrthoFinder	1	1.000	-	-		FOG0001698
OrthoInspector	1	1.000	-	-		oto41211
orthoMCL	1	0.900	-	-		OOG6_100496
Panther	1	1.100	-	-	LDO	PTHR11136
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R454
SonicParanoid	1	1.000	-	-		X2113
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800