DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fpgs and SPBC1709.17

DIOPT Version :9

Sequence 1:	NP_572814.1	Gene:	Fpgs / 32212	FlyBaseID:	FBgn0030407	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_595450.1	Gene:	SPBC1709.17 / 2540103	PomBaseID:	SPBC1709.17	Length:	505	Species:	Schizosaccharomyces pombe

Alignment Length:	520	Identity:	172/520 - (33%)
Similarity:	257/520 - (49%)	Gaps:	68/520 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 NIQCSSDNNNKDTNAAFELAIKQLNSLQSNDAAIRNSMSNSRVDTKADTIK---YLERSGLPLET 141
            |::.|....|..|. .||.||.:|||||||...:.......::......::   :|...|.....
pombe    12 NLKSSRIGMNPQTK-TFEGAINRLNSLQSNAKVLEVLRKRGKIPNDQSMVEMRHWLRCIGYQPSD 75

  Fly   142 VEQLSFIHVAGTKGKGSTCALTESLLRH---QGFRT-----GFFSSPHILFTNERIRIDGQLLSK 198
            :.:|:.||||||||||||||.|.|:|:.   .|.|:     |.::|||:....|||:::|:.:|:
pombe    76 LNRLNVIHVAGTKGKGSTCAFTSSILQQIQKSGERSIPKCIGMYTSPHLRSVCERIQLNGKPISQ 140

  Fly   199 DKFTEQFWKVYNRLWDLREHDHDMPAYFKFLTILGFHVFVAENVDVVVLEVGIGGEHDCTNIVRN 263
            :.||:.|:.|:.||.:....|.:.|.||:|||::.:|||::||||..::|||||||:|.||::..
pombe   141 ELFTKYFFDVWERLENAVGSDSEKPMYFRFLTLMAWHVFISENVDAAIIEVGIGGEYDSTNLIEK 205

  Fly   264 VRTVGITSLGLEHTELLGRTLPEIAWQKAGIIKTGSHVFTHVTQPECLEVIRQRTKEHSATL-YE 327
            .....:|||||:||.|||.|:.|||||||||.|..:...|....||.:.|::.|..|.:.:| ..
pombe   206 PYATAVTSLGLDHTSLLGNTIAEIAWQKAGIYKESAIALTCEQAPEAMNVLKNRAAERNTSLKVV 270

  Fly   328 VPPTEDYFRSKAYAPIWQTFSNLIRL-NGSLAIQLAQDWLSQSGKQQHTP--NEVKMDPQLLDGL 389
            :||.|       ..|.....|.:.:| |.|||:.|.|::..::|    .|  .:...||.:||||
pombe   271 IPPAE-------LTPDMIGLSGVHQLGNTSLAVSLVQEFYEKAG----CPFDRDPYQDPAILDGL 324

  Fly   390 ISTHWPGRCQLIEWHGMRLHLDGAHTLESMEVCTDWF--EKNVRDSVNPKILIFNRTGESGFAPL 452
            ....||||||:.|.:.::...|||||.||:|....|.  :||:.:..:.:||:||:........|
pombe   325 KYVKWPGRCQIEEINNIKWCFDGAHTKESLEATGLWLASKKNLYEDADARILLFNQQSRDDPIAL 389

  Fly   453 LKLLNRTCD-------FDMVCFVPNLA--------------TSTPNAPSQVMVRFSPEMQLNRAR 496
            |:...:..:       |..|.|..|:.              |.|.|.|           .|:...
pombe   390 LRSFLKGLESSGTGISFTHVIFSTNVTWKDAGYNPELLSINTITDNKP-----------VLHVQE 443

  Fly   497 IIASAWSDLCATEQKKDVGQVYNTLTDAFTAIRQRFPQATDNEGQLEVLVTGSIHLLGAAISALD 561
            .:...|.:...|..:..|........:...:|:|:       .....|.||||:||.|.....||
pombe   444 DLCKWWKESKGTTSEATVAPTIQEAIETVMSIKQK-------SRNTFVCVTGSLHLTGGVFVVLD 501

Fly 562 561
pombe 502 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fpgs	NP_572814.1	PLN02881	90..554	CDD:215476	166/501 (33%)
SPBC1709.17	NP_595450.1	FolC	34..482	CDD:223362	154/476 (32%)
SPBC1709.17	NP_595450.1	PEPCK_HprK	134..>181	CDD:304604	18/46 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	250	1.000	Domainoid score	I406
eggNOG	1	0.900	-	-		E1_COG0285
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6997
Inparanoid	1	1.050	251	1.000	Inparanoid score	I784
OMA	1	1.010	-	-		QHG51906
OrthoFinder	1	1.000	-	-		FOG0001698
OrthoInspector	1	1.000	-	-		otm47296
orthoMCL	1	0.900	-	-		OOG6_100496
Panther	1	1.100	-	-	LDO	PTHR11136
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R454
SonicParanoid	1	1.000	-	-		X2113
TreeFam	1	0.960	-	-
	14	13.860