DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fpgs and F25B5.6

DIOPT Version :9

Sequence 1:	NP_572814.1	Gene:	Fpgs / 32212	FlyBaseID:	FBgn0030407	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_498291.1	Gene:	F25B5.6 / 175842	WormBaseID:	WBGene00017777	Length:	521	Species:	Caenorhabditis elegans

Alignment Length:	485	Identity:	175/485 - (36%)
Similarity:	264/485 - (54%)	Gaps:	38/485 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 FELAIKQLNSLQSNDAAIRNSMSNSRVDTKADTI----KYLERSGLPLETVEQLSFIHVAGTKGK 156
            :|.:::.||.||||.|.|: .:...|.:.:|..:    ||||...:..|.:..|:.|||:|||||
Worm    47 YEESVRLLNGLQSNAATIK-KLRVQRENLQAINLPQCRKYLESLNISAEDLNALNIIHVSGTKGK 110

  Fly   157 GSTCALTESLLRHQGFRTGFFSSPHILFTNERIRIDGQLLSKDKFTEQFWKVYNRLWDLREHDHD 221
            ||.||..||:||.||.||||:||||::...|||::|||.:|:..|.|:|:.||:.:  .|||..:
Worm   111 GSACAFVESILRSQGLRTGFYSSPHLVHVRERIQVDGQPVSEQMFAEEFFHVYDII--KREHSDN 173

  Fly   222 MPAYFKFLTILGFHVFVAENVDVVVLEVGIGGEHDCTNIVRNVRTVGITSLGLEHTELLGRTLPE 286
            |||||||||:|.|.:||..||.|::||||||||:||||:|...:..|:|:|..:|..:||..|.|
Worm   174 MPAYFKFLTLLAFRIFVKLNVQVMILEVGIGGEYDCTNVVEKPKVCGVTTLDYDHMSILGNKLSE 238

  Fly   287 IAWQKAGIIKTGSHVFTHVTQPECLEVIRQRTKEHSATLYEVPPTEDYFRSKAYAPIWQ---TFS 348
            |||.||||.|.....|...|..|..||:..|.......|::.||...|..::..:|..:   .||
Worm   239 IAWHKAGIFKESVPAFYSPTTTEAEEVLIARAISKHVPLFQTPPVSAYQFARDISPGIRGAHQFS 303

  Fly   349 NLIRLNGSLAIQLAQDWLSQSG------KQQHTPNEVKMDPQLLDGLISTHWPGRCQLIEW-HGM 406
            |:     |:|:||.:.|..:.|      ......:...:...:.|.:.|..||||.|::.. ..:
Worm   304 NV-----SMALQLVRAWAEKCGFPLPGVPLSTDTSGFNVPLWMCDAIESCRWPGRSQIVSTDRNV 363

  Fly   407 RLHLDGAHTLESMEVCTDWFEKNV----RDSVNPKILIFNRTGESGFAPLLKLLNRTCDFDMVCF 467
            ...||||||.:|||.|::|..:.:    :::|. |||:|..|.:...:.|:|.|.......:|..
Worm   364 TYLLDGAHTPKSMEACSEWAAEEIVNLKKENVK-KILLFQCTADRCPSTLIKYLKPLGISQIVSC 427

  Fly   468 VPNLATSTPNAPSQVMVRFSPEMQLNRARIIASAWSDLCATEQKKDVGQ----VYNTLTDAFTAI 528
            ...|.:|...:.....:..|.:.|..:|.....||.:  :.:|.:.|.:    |::.::.|:..|
Worm   428 PTQLHSSIDKSADSANLNASRDEQAEKANQCVQAWKE--SLDQPESVTEDQMKVFDCISSAYKFI 490

  Fly   529 RQRFPQATDNEGQLEVLVTGSIHLLGAAIS 558
            ..   ||...|  :.||||||:||:|..::
Worm   491 ES---QAASQE--ILVLVTGSLHLVGGVLN 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fpgs	NP_572814.1	PLN02881	90..554	CDD:215476	174/479 (36%)
F25B5.6	NP_498291.1	folC	79..516	CDD:273659	164/452 (36%)
F25B5.6	NP_498291.1	Mur_ligase_C	350..>407	CDD:280948	22/57 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167053
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6997
Inparanoid	1	1.050	277	1.000	Inparanoid score	I1770
Isobase	1	0.950	-	0	Normalized mean entropy	S1575
OMA	1	1.010	-	-		QHG51906
OrthoDB	1	1.010	-	-		D231485at33208
OrthoFinder	1	1.000	-	-		FOG0001698
OrthoInspector	1	1.000	-	-		otm14260
orthoMCL	1	0.900	-	-		OOG6_100496
Panther	1	1.100	-	-	LDO	PTHR11136
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R454
SonicParanoid	1	1.000	-	-		X2113
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.890