DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HOXC4 and ftz

DIOPT Version :9

Sequence 1:	NP_055435.2	Gene:	HOXC4 / 3221	HGNCID:	5126	Length:	264	Species:	Homo sapiens
Sequence 2:	NP_477498.1	Gene:	ftz / 40834	FlyBaseID:	FBgn0001077	Length:	410	Species:	Drosophila melanogaster

Alignment Length:	362	Identity:	103/362 - (28%)
Similarity:	133/362 - (36%)	Gaps:	132/362 - (36%)

- Green bases have known domain annotations that are detailed below.

Human     6 YLMDSNYIDPKFPPCEEYSQNSYIPEHSPEYYGRTRESGFQHHHQELYPP-----PPPRPSYPER 65
            |...|||  ..:.|.|.||::.|       ||....:...|     ..||     |||:.:..:.
  Fly    41 YQNTSNY--QGYYPQESYSESCY-------YYNNQEQVTTQ-----TVPPVQPTTPPPKATKRKA 91

Human    66 QYSCTSL-----QGPGNSRG--HGPAQAGHHHPE---------------KSQSLCEPAP------ 102
            :....|:     :.|...|.  ..|.:...:.|:               .::....|||
  Fly    92 EDDAASIIAAVEERPSTLRALLTNPVKKLKYTPDYFYTTVEQVKKAPAVSTKVTASPAPSYDQEY 156

Human   103 ---------------------------LSGASASPSPAPPACSQP---------APDHPSSAASK 131
                                       .:|..|:|.|..|....|         :|...||:|..
  Fly   157 VTVPTPSASEDVDYLDVYSPQSQTQKLKNGDFATPPPTTPTSLPPLEGISTPPQSPGEKSSSAVS 221

Human   132 QPIVYPWMKKIHVSTVNPNYNGG---------------EPKRSRTAYTRQQVLELEKEFHYNRYL 181
            |.|       .|.....||..|.               :.||:|..|||.|.||||||||:|||:
  Fly   222 QEI-------NHRIVTAPNGAGDFNWSHIEETLASDCKDSKRTRQTYTRYQTLELEKEFHFNRYI 279

Human   182 TRRRRIEIAHSLCLSERQIKIWFQNRRMKWKKDHRLPNTK-------VRSAPPAGA-------AP 232
            ||||||:||::|.||||||||||||||||.|||..|.::.       ....||..|       ||
  Fly   280 TRRRRIDIANALSLSERQIKIWFQNRRMKSKKDRTLDSSPEHCGAGYTAMLPPLEATSTATTGAP 344

Human   233 ST---------LSAATPGTSEDHSQS----ATPPEQQ 256
            |.         .:||.|..|..||..    ...|:||
  Fly   345 SVPVPMYHHHQTTAAYPAYSHSHSHGYGLLNDYPQQQ 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HOXC4	NP_055435.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	19..130		30/179 (17%)
		Antp-type hexapeptide	135..140		0/4 (0%)
		Homeobox	159..213	CDD:395001	41/53 (77%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	214..264		17/70 (24%)
ftz	NP_477498.1	FTZ	1..248	CDD:281812	41/227 (18%)
ftz	NP_477498.1	Homeobox	257..310	CDD:278475	41/52 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000007
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810