DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Sec16 and SEC16A

DIOPT Version :9

Sequence 1:NP_001285158.1 Gene:Sec16 / 32209 FlyBaseID:FBgn0052654 Length:2326 Species:Drosophila melanogaster
Sequence 2:XP_005266191.1 Gene:SEC16A / 9919 HGNCID:29006 Length:2379 Species:Homo sapiens


Alignment Length:2613 Identity:567/2613 - (21%)
Similarity:863/2613 - (33%) Gaps:906/2613 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 HNNAPWLP-------PH-----------------QQQQQQAP-QQHPTPQQQHAMPQQQQTLPAQ 42
            |.|.|.|.       ||                 |...|..| |..|.|..||..|..:..:|:.
Human   176 HGNMPGLDRPLSRQNPHDGVVTPAASPSLPQPGLQMPGQWGPVQGGPQPSGQHRSPCPEGPVPSG 240

  Fly    43 QQQQQVYASQMFQQHQPNYWPEDQHQQQQQPQSLNYNNYFPGQQQQHPMQQQQLPPQQQLP---- 103
            ..    .|:.:  .|.|.  |...||.             ||.:|..|:    :.|...||    
Human   241 VP----CATSV--PHFPT--PSILHQG-------------PGHEQHSPL----VAPPAALPSDGR 280

  Fly   104 -----------------PQ---QQQPTQQQHTIQQQLYYPTQQQPQVPAPAEPAL---------D 139
                             |:   :|.|....|....:|    :|.|.|.....||.         |
Human   281 DEVSHLQSGSHLANNSDPESTFRQNPRIVNHWASPEL----RQNPGVKNEHRPASALVNPLARGD 341

  Fly   140 SFDNNNS---GGGGGGGRSDGWGDWG---------DWNDNSNNNN-SNGTDGLLEPTGQLLEDSF 191
            |.:|...   |.|.|.|.:....|.|         ...:..|..| |:...||            
Human   342 SPENRTHHPLGAGAGSGCAPLEADSGASGALAMFFQGGETENEENLSSEKAGL------------ 394

  Fly   192 NVQSSQGSWQAFATSNNVNN-------------NGELPPPAN---------------PQSTSLQQ 228
               |.|..:..|.:|..:..             ...||.|:|               |.::..|.
Human   395 ---SGQADFDDFCSSPGLGRPPAPTHVGAGSLCQALLPGPSNEAAGDVWGDTASTGVPDASGSQY 456

  Fly   229 QPLNQQSIPLLHQQPQSPPELGQEP-ELDAIVPPQAFQNQP-------------PTAAP------ 273
            :  |.:::..:..|...|    .|| .||...|...|:..|             .|.||      
Human   457 E--NVENLEFVQNQEVLP----SEPLNLDPSSPSDQFRYGPLPGPAVPRHGAVCHTGAPDATLHT 515

  Fly   274 --PPTSLTSFSAQ-------------------MTAVGSPIYAVGAS---SAHSAGVGA------- 307
              |.:..:|:|::                   ...||.|......|   ...|:.||.       
Human   516 VHPDSVSSSYSSRSHGRLSGSARPQELVGTFIQQEVGKPEDEASGSFFKQIDSSPVGGETDETTV 580

  Fly   308 --------------SPAPPTGVVAPPA---------HLAGIGAPPAHLAGV------------GA 337
                          ||..|||:....|         ||.|:....|..|.|            ..
Human   581 SQNYRGSVSQPSTPSPPKPTGIFQTSANSSFEPVKSHLVGVKPFEADRANVVGEVRETCVRQKQC 645

  Fly   338 SPAPSALVGASPAPIIGVGAPP-----VGAPPVGAPPADATTIA----PPAALPP--SIVPSSGS 391
            .|| :||..|||.   .:..||     :.||.|...|.::||.|    |.|..||  ::.|:...
Human   646 RPA-AALPDASPG---NLEQPPDNMETLCAPQVCPLPLNSTTEAVHMLPHAGAPPLDTVYPAPEK 706

  Fly   392 NPFKRSTGLNK-----------------RVNIMADPAAGA------PSPPA-------------- 419
            .|..|:.|..|                 ..|::..|||.|      |.||.              
Human   707 RPSARTQGPVKCESPATTLWAQSELPDFGGNVLLAPAAPALYVCAKPQPPVVQPPEEAMSGQQSR 771

  Fly   420 -PAAAIAPVAPVAPI--------PPPADQLFGMPAEAHGEGFNLIAAPPVEASLGTP-------- 467
             |::| |||.....|        ||...:...:.::|.....:|:::||.|:....|        
Human   772 NPSSA-APVQSRGGIGASENLENPPKMGEEEALQSQASSGYASLLSSPPTESLQNPPVLIAQPDH 835

  Fly   468 ---LSAPIPAPIPVPN----------ASLYASPAVPQ-AFAHLEPDNQEV----------LSAPN 508
               |:.||...:.:.|          |.:...|||.. |......:|..:          ||.|:
Human   836 SYNLAQPINFSVSLSNSHEKNQSWREALVGDRPAVSSWALGGDSGENTSLSGIPTSSVLSLSLPS 900

  Fly   509 D-ERAQYLQTSHLSEQLG---------------------EGEADQDAG-LLP-----PPGLSRLV 545
            . .::.:.|.|..||.:.                     |.:.|:.|| .||     |.|.:.:|
Human   901 SVAQSNFPQGSGASEMVSNQPANLLVQPPSQPVPENLVPESQKDRKAGSALPGFANSPAGSTSVV 965

  Fly   546 L-----------GQPELDSQQQRQVTGA-------TEQPPLNVAQAAALHMQERRADGEDTSDGE 592
            |           |.....|..|....||       |.:.|:||...:  |           ||..
Human   966 LVPPAHGTLVPDGNKANHSSHQEDTYGALDFTLSRTLENPVNVYNPS--H-----------SDSL 1017

  Fly   593 QQVRNIQTPPRRVVTGVETNAPSL-REQREVVLDGE---NLE--DREAIPPPTLAELPTTSVHHN 651
            ...:::.:.||:...|    ||:| |..::|..|.:   .||  .:|.:||...|          
Human  1018 ASQQSVASHPRQSGPG----APNLDRFYQQVTKDAQGQPGLERAQQELVPPQQQA---------- 1068

  Fly   652 ILPDEAEQLHHNNPPQAMTPLNAQQPHQQQSTLQQQHQQHSTTQQEKKRAAVGRR------TTAS 710
                        :|||....:.::..:.:....|.|.|..:.:.........|::      .::|
Human  1069 ------------SPPQLPKAMFSELSNPESLPAQGQAQNSAQSPASLVLVDAGQQLPPRPPQSSS 1121

  Fly   711 LDLESDESDE-FLQSERERDRE-------------------RERRDLMEERHSRGRSHSHYPYEG 755
            :.|.|..|.: .:.||:...:.                   |...|..:.::|       .||..
Human  1122 VSLVSSGSGQAAVPSEQPWPQPVPALAPGPPPQDLAAYYYYRPLYDAYQPQYS-------LPYPP 1179

  Fly   756 ETEDSVRGAA---HHETKSLRETHHKRNHD---SARSRRHQDPKVERERERDRERDRTWRRRSNK 814
            |.     |||   :.:..||.|..: |.:|   ||.::.::.|:.||...|             .
Human  1180 EP-----GAASLYYQDVYSLYEPRY-RPYDGAASAYAQNYRYPEPERPSSR-------------A 1225

  Fly   815 YHSGGEDPDR-SYDHSRRYNNSNYEGESD------NPEYNHMGDAELDGSGGRSSKTSR------ 866
            .||....|.| .|......:.|.:..:||      :.:|:: ||   .|...|...::|      
Human  1226 SHSSERPPPRQGYPEGYYSSKSGWSSQSDYYASYYSSQYDY-GD---PGHWDRYHYSARVRDPRT 1286

  Fly   867 -HRRSAAEEDFDDYERERNRSRRSTKPQSSAEKSRSSGGRRNYENSGR-SARADDGRRRYQDQRN 929
             .||...:.::|.|.||.           ||...|......|:....| :...||....::|   
Human  1287 YDRRYWCDAEYDAYRREH-----------SAFGDRPEKRDNNWRYDPRFTGSFDDDPDPHRD--- 1337

  Fly   930 PGAQYPVSATGYVPYGMYEQMSRNPQVYADMYAKFYGQMINSMNAAVSAAASKGGVPAGAGVIPG 994
                         |||  |::.|. .|:::..|:       |:::|.|.|:.:..:.:       
Human  1338 -------------PYG--EEVDRR-SVHSEHSAR-------SLHSAHSLASRRSSLSS------- 1372

  Fly   995 LMPSAVPVSAAQLVAATSGGSVSGSSEAAMLRERERYTHAYITQANEFHRHQYKELIYQQQQQQQ 1059
                                                            |.||.:  ||:      
Human  1373 ------------------------------------------------HSHQSQ--IYR------ 1381

  Fly  1060 QQQQQQQQREDHLNSSFSVAEDNASFY------GSHGGGSIYNQYQSYPLSSARSLSNLNGDGRN 1118
                           |.:||   |..|      ||..|...|..|:|                 |
Human  1382 ---------------SHNVA---AGSYEAPLPPGSFHGDFAYGTYRS-----------------N 1411

  Fly  1119 SRCGPYYAGSECGLDIRAAADAAPSTYGGVAGTAGPVTNTAVARPPRRRTPLQFSRPHLVASYAM 1183
            ...||.:                 ..||..|.|..|......:||   .:|.:||.||:.|.:..
Human  1412 FSSGPGF-----------------PEYGYPADTVWPAMEQVSSRP---TSPEKFSVPHVCARFGP 1456

  Fly  1184 -SLLLKVKPKYAGRGRLRNDVEV-APPRIRDGTSSL--LRMYPGPLQGRKLHKDKIISFCKEQIR 1244
             ..|:||.|.....|:... ||| :...:...||..  :|.:||||.....||..:|:|.:.:  
Human  1457 GGQLIKVIPNLPSEGQPAL-VEVHSMEALLQHTSEQEEMRAFPGPLAKDDTHKVDVINFAQNK-- 1518

  Fly  1245 LGPTKGCTALYATQKKPQGSVTKYRASHALMWHLLILLLRQNGYIADTDVGDLLLENQQ------ 1303
                    |:...|.  :..:.|..||  |:|:.::||.||||.:..||:.:|||.:.:      
Human  1519 --------AMKCLQN--ENLIDKESAS--LLWNFIVLLCRQNGTVVGTDIAELLLRDHRTVWLPG 1571

  Fly  1304 EYPYDPSEFEAENEPDADAEQDAAAPADKTVDSDLDSESAAGVTPAEPLAAGAATSSINGADAAN 1368
            :.|.:.:..:..||.....|::.:..|.                          .|.:.|..|| 
Human  1572 KSPNEANLIDFTNEAVEQVEEEESGEAQ--------------------------LSFLTGGPAA- 1609

  Fly  1369 AATPLSEQAATDKFRSYVLRGNVEEALQWATDNGLWTHAFFLALYEDRYALTDVAQKFLNRAIKA 1433
            ||:.|..:  |::||..:|.|..::||:.|..||||.||..||...|......|..:|.| ::..
Human  1610 AASSLERE--TERFRELLLYGRKKDALESAMKNGLWGHALLLASKMDSRTHARVMTRFAN-SLPI 1671

  Fly  1434 NDPLQTLYQMKSCHTPACVSQLRDEQWGDWRSHLSILVTNKSRQPEYDRSSVVALGDTLFQRGDI 1498
            ||||||:||:.|...||..:...||:|||||.||:::::|.:...:.:..::..:||||..||.:
Human  1672 NDPLQTVYQLMSGRMPAASTCCGDEKWGDWRPHLAMVLSNLNNNMDVESRTMATMGDTLASRGLL 1736

  Fly  1499 YAAHFCYLVAQEEFGRYDSSATELTTLTANVPRLILLGSSHYKHFNEFASNEAIIMTEIYEYARS 1563
            .|||||||:||..||.|    |:.||      :|:|:||:|...|.:||:||||..||.||||:|
Human  1737 DAAHFCYLMAQAGFGVY----TKKTT------KLVLIGSNHSLPFLKFATNEAIQRTEAYEYAQS 1791

  Fly  1564 LFDPKFSIAHFQHYKFLLATRILDYGQHFRCTNYLEQIARHIELKPESYDSNFIQRVCGLAERLR 1628
            |......:..||.:||:.:.|:.:.|...:..:|.|.||:.|..:|..|....|.::..:|.:||
Human  1792 LGAETCPLPSFQVFKFIYSCRLAEMGLATQAFHYCEAIAKSILTQPHLYSPVLISQLVQMASQLR 1856

  Fly  1629 YHDPILINRVSFASPPNATSKDSAAAEEKAWLRQLRSLAYVQPQQEQLQQLQQNQQVQQEQNDID 1693
            ..||.|..:         ..::|.||  ..||..|         |:..:|:::...|..:...:.
Human  1857 LFDPQLKEK---------PEEESLAA--PTWLVHL---------QQVERQIKEGAGVWHQDGALP 1901

  Fly  1694 QQF-AEVNKQFRELNMQYESNSNMENTLQPQL-----PPVDQQP-----PQQQQQVLSESYQQPT 1747
            ||. ...:.:..:|:....|.........|.|     .|....|     |...|.:.......|.
Human  1902 QQCPGTPSSEMEQLDRPGLSQPGALGIANPLLAVPAPSPEHSSPSVRLLPSAPQTLPDGPLASPA 1966

  Fly  1748 Q--QYYEPPPQAPTES--------------DPYGQGQPSYYDPNAGQLHY-------DPNAAQHQ 1789
            :  .:..|.|..|.|.              :|.|.|.|....|...:.|.       ||...   
Human  1967 RVPMFPVPLPPGPLEPGPGCVTPGPALGFLEPSGPGLPPGVPPLQERRHLLQEARSPDPGIV--- 2028

  Fly  1790 YDQQQPQPQP--------------------TPSYGQIEPGTEAYQPGQATADPAAVPSGYGYDYW 1834
                 ||..|                    |||  :..|.:|| .||...||             
Human  2029 -----PQEAPVGNSLSELSEENFDGKFANLTPS--RTVPDSEA-PPGWDRAD------------- 2072

  Fly  1835 SGTQQPPYGDEP-----NENQAALKDEEEEDEEQDEQQILQY-----AKQQILQQTKQQQLQQEQ 1889
            ||..|||....|     ...|||.|  |.::.::.|....::     ..:..|...|.:.:..::
Human  2073 SGPTQPPLSLSPAPETKRPGQAAKK--ETKEPKKGESWFFRWLPGKKKTEAYLPDDKNKSIVWDE 2135

  Fly  1890 HTRSNGAASINNRFKSNALKQERSSGSLRKRQEASRTATIAAAAAAIAQITPATVAAAATPPAAS 1954
              :.|...::|..      ::|:.:   ......|...|:.||..|:    |.       ||.|.
Human  2136 --KKNQWVNLNEP------EEEKKA---PPPPPTSMPKTVQAAPPAL----PG-------PPGAP 2178

  Fly  1955 AKAFNLNDVSSFSSTNKRHQATSSSNNRSSSNQAAAAAAATKAAAIATVPA-----APNQLLSCR 2014
            ...:      |..:...|.:.....|...:.....|.|.|...|.:|.:|.     .|..:.|.|
Human  2179 VNMY------SRRAAGTRARYVDVLNPSGTQRSEPALAPADFVAPLAPLPIPSNLFVPTPVSSVR 2237

  Fly  2015 KS--NSQNSPYLATPKTLTTP----------TRFIAAKAATVTATPTAPATSTTTSTTIGARGSS 2067
            ..  :.:|...||    |::|          |......||...|.|.........|:.....|| 
Human  2238 PQGRSGRNDGLLA----LSSPDAEEPQLPDGTGREGPAAARGLANPEPAPEPKVLSSAASLPGS- 2297

  Fly  2068 TKRVYFNLPSTIAESEQEFEHELDYDEEMEEENSMALAQAKPNVHLARKPHIVFNGTYPIDMPLT 2132
                  .|||:..|..|        ..|:...:||:....:.:.|        ||.. |.|:|..
Human  2298 ------ELPSSRPEGSQ--------GGELSRCSSMSSLSREVSQH--------FNQA-PGDLPAA 2339

  Fly  2133 QGQSQLKSNSYDP 2145
            .|........|:|
Human  2340 GGPPSGAMPFYNP 2352

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sec16NP_001285158.1 ACE1-Sec16-like 1371..1631 CDD:187750 100/259 (39%)
SEC16AXP_005266191.1 ACE1-Sec16-like 1497..1859 CDD:187750 137/415 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165150926
Domainoid 1 1.000 176 1.000 Domainoid score I3628
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001693
OrthoInspector 1 1.000 - - otm41870
orthoMCL 1 0.900 - - OOG6_105006
Panther 1 1.100 - - O PTHR13402
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1306
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
87.960

Return to query results.
Submit another query.