DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec16 and Sec16b

DIOPT Version :9

Sequence 1:	NP_001285158.1	Gene:	Sec16 / 32209	FlyBaseID:	FBgn0052654	Length:	2326	Species:	Drosophila melanogaster
Sequence 2:	NP_001153458.1	Gene:	Sec16b / 89867	MGIID:	2148802	Length:	1051	Species:	Mus musculus

Alignment Length:	1283	Identity:	301/1283 - (23%)
Similarity:	471/1283 - (36%)	Gaps:	318/1283 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   828 HSRRYNNSNYEGESDNPEYNHMGDAELDGSGGRSSKTSRHRRSAAEEDF-DDYERERNRSRRS-- 889
            |.|...:|.|.|:    :|:...||              |:.|.:::|. ||:::..:.||..
Mouse    27 HYRPRLHSQYSGD----KYHQWQDA--------------HKNSKSQQDLRDDHQQSHSVSRSGEW 73

  Fly   890 TKPQSSAEKSRSSGGRRNYENSGRSARADDGRRRYQDQRNPGAQYPVSATGYVPYGMYEQMS-RN 953
            ::|.|.|:..:.|.....|..||           |.|                ||..|...: |:
Mouse    74 SQPVSGADYLKGSYPSHLYSRSG-----------YGD----------------PYQRYHTPTPRD 111

  Fly   954 PQVYADMYAKFYGQMINSMNAAVSAAASKGGVPAGAGVIPGLMPSAVPVSAAQLVAATSGGSVSG 1018
            ...|.:.|  ::|.                         |.|:|
Mouse   112 EYAYGNYY--YHGH-------------------------PQLLP--------------------- 128

  Fly  1019 SSEAAMLRERERY----THAYITQANEFHRHQYKELIYQQQQQQQQQQQQQQQREDHLNSSFSVA 1079
              |..:.|:...|    .|.......|.||.::..........|.|...:...|:.  .:|.|..
Mouse   129 --EERVARQGSPYIWHEDHGDQRYFGEHHREKHNGTFGANSDTQFQFTSKNPYRDS--PASVSGQ 189

  Fly  1080 EDNASFYGSHGGGSIYNQYQSYPLSSARSLSNLNGDGRNSRCGPYYAGSECGLDIRAAADAAPST 1144
            |....|:.....     |.|...|:|..||...:..|.:|          ...::.....|||..
Mouse   190 EQPGEFFPESEA-----QKQKPLLTSKSSLLQQHESGLSS----------SSYELSQYMTAAPEE 239

  Fly  1145 YGGVAGTA-GPV--TNTAVARPPRRRTPLQFSRPHLVASYAM-SLLLKVKPKYAGRGR------- 1198
            |..:...| .|:  .:|:...|   :.|::|..||:..|:.. ..|:.|.|.....|:
Mouse   240 YEPMVSAAWRPIQADDTSATVP---KAPMRFYVPHVSVSFGPGGQLVCVPPNSPADGQTALVEVH 301

  Fly  1199 ----LRNDVEVAPPRIRDGTSSLLRMYPGPLQGRKLHKDKIISFCKEQIRLGPTKGCTALYATQK 1259
                |.||.|         ....:|.:||||....:||..|::||:::          |....:.
Mouse   302 SMEVLLNDFE---------DQEEMRAFPGPLIREDIHKVDIMTFCQQK----------ATQCLKS 347

  Fly  1260 KPQGSVTKYRASHALMWHLLILLLRQNGYIADTDVGDLLLEN---QQEYPYDPSEFEAENEPDAD 1321
            :..||     ...||:|.||:||.||||.:..:|:.:||:::   .::|...|......|..|.|
Mouse   348 ETPGS-----RDSALLWQLLVLLCRQNGSMVGSDIAELLMQDCKKLEKYKRQPPVANLINLTDED 407

  Fly  1322 AEQDAAAPADKTVDSDLDSESAAGVTPAEPLAAGAATSSINGADAANAATPLSEQAATDKFRSYV 1386
                                        .|:.:......:.|....|..||..   ..:||...:
Mouse   408 ----------------------------WPVLSSGTRDLLTGEIPPNVDTPAQ---IVEKFTKLL 441

  Fly  1387 LRGNVEEALQWATDNGLWTHAFFLALYEDRYALTDVAQKFLNRAIKANDPLQTLYQMKSCHTPAC 1451
            ..|..:|||:||..|.||.||.|||...|......|...|.: .:..|||||||:|:.|...|..
Mouse   442 YYGRKKEALEWAMKNHLWGHALFLASKMDPRTYNWVMSGFTS-TLALNDPLQTLFQLMSGRIPQA 505

  Fly  1452 VSQLRDEQWGDWRSHLSILVTNKSRQPEYDRSSVVALGDTLFQRGDIYAAHFCYLVAQEEFGRYD 1516
            .:...|:||||||.||:::::|::...|..:.::|::||||..:|.:.|:|||||:|...||.|
Mouse   506 ATVCGDKQWGDWRPHLAVILSNQAGDTELYQRAIVSMGDTLAGKGLVEASHFCYLMAHVPFGHY- 569

  Fly  1517 SSATELTTLTANVPRLILLGSSHYKHFNEFASNEAIIMTEIYEYARSLFDPKFSIAHFQHYKFLL 1581
                     |.....|.|:||||.:.|.:||:.|||..|||:||.:.|..||..|..||.||.|.
Mouse   570 ---------TVKTDHLALVGSSHSQEFMKFATIEAIQRTEIFEYCQMLGRPKSFIPSFQVYKLLY 625

  Fly  1582 ATRILDYGQHFRCTNYLEQIARHIELKPESYDSNFIQRVCGLAERLRYHDPILINRVSFASPPNA 1646
            |:|:.|||...:..:|.|.|...:..:..|.....:..:..|||:|:..||:::.|       ..
Mouse   626 ASRLADYGLASQALHYCEAIGAAVLSQEGSSHPVLLAELIKLAEKLKLSDPLVLER-------RR 683

  Fly  1647 TSKDSAAAEEKAWLRQLRSLAYVQPQQEQLQQLQQN-----QQVQQEQNDIDQQFAEVNKQFREL 1706
            ..:|.    |..||.|||         .:.:.|:||     :......:||.......:..:.:|
Mouse   684 GDRDL----EPDWLVQLR---------RKHKDLEQNRTGAPRDPDSTPSDIYGAGGTTDTPYPDL 735

  Fly  1707 --NMQYESNSNMENTL-----QPQLP-PVDQQPPQQQQQVLSESYQQPTQQYYEPPPQAPTESDP 1763
              :..|..:|...:||     |..|. |:.||....|:...|.....|...|..|.......|..
Mouse   736 SGHQNYSEDSEYSSTLWSTAEQTSLTNPLAQQSFPLQRDTYSGHMGTPVPLYSVPATHLAVTSGA 800

  Fly  1764 YGQ-----GQPSYYDPNAGQLHYDPNAAQHQYDQQQPQPQPTPSYGQIEPGTEAYQPGQATADPA 1823
            .|.     |.|      .|::..|             ..:..|::|:          ...|.:|.
Mouse   801 SGSSVAVTGTP------GGRVGED-------------MLRTHPAFGE----------NTMTQEPL 836

  Fly  1824 AVPSGYGYDYWSGTQQPPYGDEP--NENQAALKDEEEEDEEQDEQQILQYAKQQILQQTKQQQLQ 1886
            ..|.  |.:..|..|.|.....|  :|:.||...|:||.......      |......:::.:|.
Mouse   837 EDPD--GLEVISSLQTPAAPRVPSFSEDSAASAKEDEEGSSDGAD------KPSHPDASQKGKLG 893

  Fly  1887 QEQHTRSNGAASINNRFKSNALKQERSSGSLRKRQEASRTATIAAAAAAIAQITPATVAAAATPP 1951
            ..::|:|:|.... :.|:|.......:||     .|.|..::.:..:...:....|:...:.|||
Mouse   894 DGKNTKSSGFGWF-SWFRSKPASSVSTSG-----DEDSSDSSDSEESPRASSPHHASPGLSPTPP 952

  Fly  1952 AASAKAFNLNDVSSFSSTNKRHQATSSSNNRSSSNQAAAAA-------AATKAAAI------ATV 2003
            ..|.   :|...|:||      :.|..|..:.|||.:..|.       :.|:..:.      ..:
Mouse   953 LTSP---SLPGASTFS------RGTGGSILQGSSNSSGIAEGMGIGGFSGTQGVSSEFYSQPGAL 1008

  Fly  2004 PAAPNQLLSCRKSNSQNSPYLATPKTLTTPTRFIAAKAATVTATPTAP 2051
            |..|....:....|....|.|.|..:|..|.|....:      .||.|
Mouse  1009 PPPPTLQGAVPLYNPSQVPQLPTASSLNRPNRLAQRR------YPTQP 1050

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec16	NP_001285158.1	ACE1-Sec16-like	1371..1631	CDD:187750	98/259 (38%)
Sec16b	NP_001153458.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..109		27/126 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	157..203		7/52 (13%)
		Central conserved domain (CCD), required for localization to endoplasmic reticulum exit sites. /evidence=ECO:0000250\|UniProtKB:Q96JE7	263..708		159/530 (30%)
		ACE1-Sec16-like	319..675	CDD:187750	132/412 (32%)
		PHA03307	674..>1027	CDD:223039	82/424 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	703..754		10/50 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	798..820		6/40 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	850..1051		47/228 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841043
Domainoid	1	1.000	170	1.000	Domainoid score	I3764
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001693
OrthoInspector	1	1.000	-	-		otm43920
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13402
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1306
SonicParanoid	1	1.000	-	-		X4658
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.970