Protein Alignment Sec16 and sec16b

DIOPT Version :10

• Sequence 1: NP_001285158.1
• Gene: Sec16 / 32209
• FlyBaseID: FBgn0052654
• Length: 2326
• Species: Drosophila melanogaster
• Sequence 2: XP_068074413.1
• Gene: sec16b / 553356
• ZFINID: ZDB-GENE-050208-274
• Length: 935
• Species: Danio rerio
• Alignment Length: 1251
• Identity: 282/1251 - (22%)
• Similarity: 426/1251 - (34%)
• Gaps: 409/1251 - (32%)

  Fly   737 LMEERHSRGRSHSHYPYEGETEDSVRGAAHHETKSLRETHHKRNHDSARSRRHQDPKVERERERD 801
            :||.|....|... |.|:               .|.|:.|::.:|.|    ::..|..|     .
Zfish     1 MMEPRREGWRMPG-YQYQ---------------SSDRDDHYRSSHQS----QYYYPPTE-----S 40

  Fly   802 RERDRTWRRRSNKYHSGGEDPDRSYDHSRRYNNSNYEGESDNPEYNHMGDAELDG-SGGRSSKTS 865
            |.|:|.|::...:|.|....|                  ...|||       :.| |...:|...
Zfish    41 RGRERQWQQVDPRYGSYMTSP------------------PPKPEY-------IPGYSSAYASNQP 80

  Fly   866 RHRRSAAEEDFDDYERERNRSRRSTKPQSSAEKSRSSGGRRNYENSGRSARADDGRRRYQDQRNP 930
            .|.|..:.:::|
Zfish    81 SHFRPHSRQEYD----------------------------------------------------- 92

  Fly   931 GAQYPVSATGYVPYGMYEQMSRNPQVYADMYAKFYGQMINSMNAAVSAAASKGGVPAGAGVIPGL 995
                 .|.:.|.||       |....|.| |..::....:|              |.|.|
Zfish    93 -----YSTSSYWPY-------REDYGYYD-YHGYHRTQYSS--------------PDGGG----- 125

  Fly   996 MPSAVPVSAAQLVAATSGGSVSGSSEAAMLRERERYTHAYITQANEFHRHQYKELIYQQQQQQQQ 1060
                        .:.|.|....|.....:.:|..|.:                   |..||....
Zfish   126 ------------WSQTDGWRTEGHQGQGLTQESARAS-------------------YSDQQGYSF 159

  Fly  1061 QQQQQQQR---EDHLNSSFSVAEDNASFYGSHGGGSIYNQYQSYPLSSARSLSNLNGDGRNS--- 1119
            :...|..|   |.|..|.     ||     .:|.|.:|:.         .:|:|....|.:|
Zfish   160 KTDSQHDRGVSERHRESM-----DN-----GNGTGEVYDN---------SALANSKASGLSSSSY 205

  Fly  1120 RCGPYYAGSE-CGLDIRAAADAAPSTYGGVAGTAGPVTNTAVARPPRRRTPLQFSRPHLVASYA- 1182
            ....|..|:| ..|::                    :::|.|.  |....||:||.||:..|:.
Zfish   206 ELSQYMNGAEQSELEL--------------------ISHTGVV--PVEVAPLKFSIPHVAVSFGP 248

  Fly  1183 MSLLLKVKPKYAGRGRLRNDVEVAPPRIRDGTSSL------------LRMYPGPLQGRKLHKDKI 1235
            ...|:.|.|..|..|.        |.::.  ..||            :|.:||||....|||...
Zfish   249 AGQLVWVSPALASEGE--------PAQVE--LHSLEVILCDTHAQHDMRDFPGPLAREDLHKVDA 303

  Fly  1236 ISFCKEQIRLGPTKGCTALYATQKKPQGSVTKYRASHALMWHLLILLLRQNGYIADTDVGDLLLE 1300
            |:|              |:..::...:....:...|.||:||.||||.||||.|..:||.:||:.
Zfish   304 INF--------------AIQMSEMCLKDEKLEDHTSAALLWHFLILLCRQNGRILGSDVAELLMR 354

  Fly  1301 NQQEYPYDPSEFEAENEPDADAEQDAAAPADKTVDSDLDSESAAGVTPAEPLAAGAATSSINGAD 1365
            ...               ......|.|.|||.....||..      ||.      ....::|.:|
Zfish   355 ESS---------------SLGVWGDTAEPADGKSLIDLSE------TPT------VEKETLNFSD 392

  Fly  1366 AANAATPLSEQAATDKFRSY---VLRGNVEEALQWATDNGLWTHAFFLALYEDRYALTDVAQKFL 1427
            ......|..::|.....:.|   :|.|..:|||:.|..:|.|.||.|||...|..:...|..:|.
Zfish   393 LLTGFPPTDKEAEEQNLQKYTKLLLSGRKKEALESAMQSGQWGHALFLASKMDSRSYNTVLSRFT 457

  Fly  1428 NRAIKANDPLQTLYQMKSCHTPACVSQLRDEQWGDWRSHLSILVTNKSRQPEYDRSSVVALGDTL 1492
            . ::..:||||||:|:.|...||.......|:|||||.||:::::|::..|.....|::|:||||
Zfish   458 G-SLTPSDPLQTLFQLLSGRIPAVSMSWSSEKWGDWRPHLAVMLSNETTDPVIHHRSIIAMGDTL 521

  Fly  1493 FQRGDIYAAHFCYLVAQEEFGRYDSSATELTTLTANVPRLILLGSSHYKHFNEFASNEAIIMTEI 1557
            ..|..::|:|.|||.||..||.|.:.:          .||:||||.....|::|..|.||..||:
Zfish   522 ASRDMLFASHICYLTAQCPFGWYRNRS----------ERLVLLGSKQSVMFSKFCHNSAIRCTEL 576

  Fly  1558 YEYARSLFDPKFSIAHFQHYKFLLATRILDYGQHFRCTNYLEQIAR--------HIELKPESYDS 1614
            :||.:.|.:.:|.|..||.||||.|.|:||.|...:..:|.|.:.:        |:.|
Zfish   577 FEYCQRLGNAEFVIPAFQVYKFLYACRLLDCGLVSQAFHYCEVVGKALLRIDQPHVVL------- 634

  Fly  1615 NFIQRVCGLAERLRYHDPILINRVSFASPPNATSKDSAAAEEKAWLRQLR------------SLA 1667
                    |.|.::     |::|:.|:......:.|.....:..||.|:|            |..
Zfish   635 --------LGELIK-----LVDRLKFSEAQLNDTGDGQLFLDPDWLVQIRCRHQTLLGENYCSET 686

  Fly  1668 YVQPQQEQLQQLQQNQQVQQEQNDIDQQFAEVNKQFRELNMQYESNSNMENTLQPQLPPVDQQPP 1732
            |..|.:|.......|:.         ..|.|         .|.|:..|.....:...||....|.
Zfish   687 YQSPAEETSWTQDSNKY---------SDFTE---------GQAEAIDNPSTETESSNPPYSAIPH 733

  Fly  1733 QQQQ-----QVLSESYQQ--------------PTQQYYEPPPQAPTE---------SDPYGQGQP 1769
            ...|     .::|.||..              ||||....||..|||         ...|.....
Zfish   734 TDAQFEGTYSLMSHSYSSEEQAPKTIAPVPLYPTQQPMTLPPVTPTEMFGPPSVSVEQSYANDSS 798

  Fly  1770 SYYDPNAGQLH--YDPNAAQHQYD-------QQQPQPQPTPSYGQIEP-GTEAYQPGQATADPAA 1824
            :|:|    .||  ...::.::..|       :.....:...:.|::.. ||...:..: |...:|
Zfish   799 TYHD----DLHNAMSSSSPRNYTDTGGDFSAEAMIASENDATVGKVNQFGTFPSEDNK-TKTQSA 858

  Fly  1825 VPSGYGYDYWSGTQQPPYGDEPNENQAALKDEEEEDEEQ---------DEQQILQYAKQQILQQT 1880
            ..|..|  ::||..:....|||.|.   :.|.:...||.         ..:.||:..:.|....:
Zfish   859 KASKPG--WFSGWFKSKPKDEPKEE---IPDPDSPTEESTANFPFPPPPPRSILKTEQPQFNPFS 918

  Fly  1881 KQQ-QLQQEQHTRSNG 1895
            |:. |.|.:|.|.|.|
Zfish   919 KRAGQSQNQQQTLSEG 934

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec16	NP_001285158.1	DUF4813	<279..379	CDD:435117
		ACE1-Sec16-like	1371..1631	CDD:187750	91/270 (34%)
sec16b	XP_068074413.1	ACE1-Sec16-like	289..648	CDD:187750	132/430 (31%)