Protein Alignment Sec16 and sec16

DIOPT Version :10

• Sequence 1: NP_001285158.1
• Gene: Sec16 / 32209
• FlyBaseID: FBgn0052654
• Length: 2326
• Species: Drosophila melanogaster
• Sequence 2: NP_594985.1
• Gene: sec16 / 2542678
• PomBaseID: SPAC29B12.07
• Length: 1995
• Species: Schizosaccharomyces pombe
• Alignment Length: 1961
• Identity: 363/1961 - (18%)
• Similarity: 609/1961 - (31%)
• Gaps: 635/1961 - (32%)

  Fly   477 PVPN----ASLYASPAVPQAFAHLEPDNQE-------------------VLSAPNDERAQYLQTS 518
            ||.|    |::.:|..|.:|.:.||.:|.|                   |.|.|..:..:..:.:
pombe   295 PVSNDNIKANIESSTTVDRASSQLESENNESTFFVHNQNSSGQHQTLDFVASKPVTDTPELSKEN 359

  Fly   519 HL--SEQLGEGEADQDAGLLPPPGLSRLVLGQPELDSQQQRQVTGATEQPPLNVAQAAALHMQER 581
            .|  ||.|.:          |.|.|.     :.|:|..:..:|    |.|...|...:|:....:
pombe   360 TLVSSENLND----------PKPNLP-----ETEVDFGEPLEV----EAPSFVVQNNSAVQPTTQ 405

  Fly   582 RADGEDTSDGEQQVRNIQTPPRRVVTGVETNAPSLREQREVVLDGENLEDREAIPPPTLAELPTT 646
            :...:.|.....::.|:..||..                   .:.||.:|...:..|.::..| .
pombe   406 KTSEDSTDLHTNEIPNVAQPPSS-------------------FEKENNKDTSKLENPDISSSP-L 450

  Fly   647 SVHHNILPDEAEQLHHNNPPQAMTPLNA---QQPHQQQSTLQQQHQQHSTTQQEKKRAAVGRRTT 708
            |...::.|::.|:   .|...|...||:   .||.:.||.......:..|....:......:.|.
pombe   451 SPTEDLFPNDPEE---ENLFSAALGLNSNTGSQPSETQSKPSIDPSESITVTDNQDSLLFSQLTN 512

  Fly   709 ASLDLE--SDESDEFLQSERERDRERERRDLMEE--RHSRGRSHSHYPYEGETEDSVRGAAHHET 769
            .:|..|  :..|:..:..|...| :.|...||..  ..|..:::.:.|     :.|....|:...
pombe   513 NALQAENATKVSENTINDEELID-DSEFTSLMSNFLESSTVQTNKYLP-----KSSASPPANAPI 571

  Fly   770 KSLRETHHKRNHDSAR-----------SRRHQDP-KVERERERDRERDRTWRRRSNKYHS----- 817
            .| .:.|...|..:||           ..::..| .:..|..:..::.|:..:..|:.:|
pombe   572 VS-SDVHKNENAGTARRAPQSGAFVASKAKYSSPYDLPEEIVQVAQQKRSVSQNYNRQYSFQPRP 635

  Fly   818 -GGEDPDRSYDHSRRYNNSNYEGESDNP---EYNHMGDAELDGSGGRSSKTSRHRRSAAEEDFDD 878
             ...:|.||........|:.. .::.||   .|.|          |....|...|.::    |:.
pombe   636 ATPSNPPRSLPPPSGQVNAPM-SQTPNPISFAYQH----------GTPLATPTMRANS----FNS 685

  Fly   879 YERERNRSRRSTKPQSSAEKSRSSGGRRNYENSGRSARADDGRRRYQDQRNPGAQYPVSATGYVP 943
            |            |.||||..|            |.|....|       ..|....|.:.|....
pombe   686 Y------------PASSAEPIR------------RPATTTVG-------HTPNLYSPKTNTYNSR 719

  Fly   944 YGMYEQ-------MSRNPQVYADM-YAKFYGQMIN----------SMNAAVSAAASKGGVPAGAG 990
            :..||.       :|..|.:..:. |....|::.|          |.::...||.::..:....|
pombe   720 HMAYEMTKSHINVISPGPSLQVNAPYTPTSGELGNKVSNPTKEFVSTSSYAPAANTRNAIIREPG 784

  Fly   991 VIPGLMPSAVPVSAAQLVAATSGGSV---------------------SGSSEAAMLRERERYTHA 1034
            ::..|.|...||.:.:....:.|.|.                     |..|...:.|....|...
pombe   785 ILSPLSPRVQPVLSRRESIISMGSSASSYVPLEIAPRPMSSLEHTMNSAMSPGNLQRTANLYKPM 849

  Fly  1035 YITQANEFHRHQYKELIYQQQQQQQQQQQQQQQREDHLNSS-----------FS--VAEDNASFY 1086
            ....|........:|..|..|.|.....:..|.....|.:|           |:  .|:.:|:.|
pombe   850 TTPNAYNIKNSNQRETKYPYQPQAINYSEVTQPGSSSLPTSGEEANIIRSPGFTPLAAQKDATIY 914

  Fly  1087 -GSHGGGSIYNQYQSYPLSSARSLSNLNGDGRNSRCGPYYAGSECGLDIRAAADAAP------ST 1144
             .||...::|              .|::.:.|::.          |:.....:|..|      |.
pombe   915 TPSHAQATLY--------------GNMDNNDRDNE----------GIHDILQSDMEPVLPPHNSA 955

  Fly  1145 YGGVAGTAGPVTNTAVARPPRRRTPLQFSRPHL------------------VASYAMSLLLKVKP 1191
            |...|    ||::.:...  ..|.|:....|.|                  ...||.|:.....|
pombe   956 YHANA----PVSSHSEGL--NNRLPISPLPPQLHKTGTPSHQHGFDTAETTAKQYAPSIPPNFNP 1014

  Fly  1192 KYAGRGRLRNDVEVAPPRIRDGTSSL-----------------LRMYPGPLQGRKLH-------- 1231
            . .....:...|.:....:....|||                 |.:...||....||
pombe  1015 N-VSIDTMTEGVALPSATLDSDKSSLHKRSAELSRNNSPRPDFLPLPNQPLLHSNLHSPVSPVVD 1078

  Fly  1232 --KDKIISFCKEQ---IRLGPTKGC----------TALYATQKKPQGSVTKYRASHALMWHLLIL 1281
              :|..:.|...|   ...||   |          :.||.|    .|..||:.|
pombe  1079 SNEDSRLKFLSTQRPAFSFGP---CGTIVMAFSTPSGLYTT----SGKGTKFIA----------- 1125

  Fly  1282 LLRQNGYIADTDVGDLLLENQQEY--------PYDPSEFEAENEPDADA---------------E 1323
                 |.|....:||:|.:   ||        ||..|..:.:....|:|               |
pombe  1126 -----GPIKIEKLGDVLTD---EYRHLKEFKGPYLASNGKVDKHGKAEAIEWLSKYIDRLNQSLE 1182

  Fly  1324 QDAAAPADKTV-------------------DSDLDSESAAGVTPAE---PLAAGAATS------- 1359
            .|     ||.:                   |..|..|....:....   |.....|||
pombe  1183 YD-----DKNITLKDKLLLLQCLKMLLEVSDRKLIVEKLRPILLPSFEIPEPCNTATSVQELINP 1242

  Fly  1360 SINGADAANAATPLSEQAATDKFRSYVLRGNVEEALQWATDNGLWTHAFFLALYED--------- 1415
            .||..|:...|:.....:...:|..|:|.||.:|||.:|.....|.:|..:|...|
pombe  1243 EINQDDSPIVASRYCTTSFLHRFYEYLLSGNKDEALTYALQQKQWPYAIIVAHSIDAKTFQGVVR 1307

  Fly  1416 RYALTDVAQKFLNRAIKANDPLQTLYQMKSCHTPACVSQ---------LRDEQWGD-----WRSH 1466
            .:..::|.:..|...:..|  ||...|:.|....:.:|:         |.|:....     |:..
pombe  1308 TFCKSEVKESMLRSGVGVN--LQLSLQLMSDAHASSMSEFSSSTSLLNLADQSQASNALVAWKEL 1370

  Fly  1467 L-SILVTNKSRQPEYDRSSVVALGDTLFQRGDIYAAHFCYL--VAQEEFGRYDSSATELTTLTAN 1528
            | :|:..:.|.|.|    ::..||..|.|...:||||..|:  ::.:......:|..||..|:
pombe  1371 LYNIIANHYSDQKE----ALRVLGTLLLQENRVYAAHLVYILSLSPDVCSNKSNSLFELVGLS-- 1429

  Fly  1529 VPRLILLGSSHYKHFNEFASNEAII----MTEIYEYARSLFDPKFSI--AHFQHYKFLLATRILD 1587
                        || |.:.|::.:.    :||:.|...:::..|..:  .|...|:...|..:.:
pombe  1430 ------------KH-NLYPSHDDLFDVTQLTEVLELVFNVYSEKTPVFFTHLVPYRLYEAEVLAE 1481

  Fly  1588 YGQHFRCTNYLEQIARH---IELKPESYDSNFIQRVCGLAERLRYHDPILINRVSFASPPNATSK 1649
            .|:......|.|.|..:   :..|..:.|..|:.||..|.:::                    .:
pombe  1482 AGEVSAARKYCELIGNYLNRVAKKSNNVDPGFVLRVRDLTQQI--------------------LE 1526

  Fly  1650 DSAAAEE--KAWLRQLRS-------LAYVQPQQEQLQQLQQNQQVQQEQNDIDQQFAEVNKQFRE 1705
            :||.:|:  .:||.:..|       |:.:..:..:......|..|.:........|.:|..|
pombe  1527 NSAGSEDISSSWLGRTVSRPRLDTVLSSLGSKFSKFVAGDPNFDVMRPATVGPGPFGKVASQ--- 1588

  Fly  1706 LNMQYESNSN---MEN-----------TLQPQLPPVDQQ-------PPQQQQQVLSESYQQPTQQ 1749
            .|:..::|:|   ||:           :.|.:.|...|:       .|.::...::|:.......
pombe  1589 KNLTVQTNTNNAAMESFYSDRPTSSGPSYQNRTPLTGQESMNMGVYSPYRRSTEIAENMSMDGNA 1653

  Fly  1750 YYEPPPQAP-TESDPYGQGQPSY-YDPNAGQLHYDP-----NAAQHQY----DQQQPQ------- 1796
            |    |..| ::.:||   .|.: .:.||..|...|     |.|.:.|    ..|:|:
pombe  1654 Y----PYTPASQENPY---TPRHSQEDNASVLSQQPLTFYSNVADNSYMPVSASQEPKMGMGTAF 1711

  Fly  1797 PQPT-----------PSYGQIEPGTEAYQPG-QATADP----AAVPSGYGYDYWSGTQQPPYG-- 1843
            ..||           ..|..::|.: |:.|. |.|..|    |.|||...         |..|
pombe  1712 NMPTNEVHGVGAEMASPYQPLQPAS-AHLPNLQPTLAPINQNAYVPSNIA---------PAMGAM 1766

  Fly  1844 -DEPNENQAALKDEEEEDEEQDEQQILQYAKQQILQQTKQQQLQQEQHTRSNGAASINNRFKSNA 1907
             ..|:....|...|.....:...||..|.|.|.:....:|::.:::|..::          |.||
pombe  1767 QSAPSAEAVAAPSESLNLNKDRSQQAKQAAAQNVADLVRQEEEKEKQKQKA----------KKNA 1821

  Fly  1908 LKQERSS-----GSLRKRQEASRTATIAAAAAAIAQITPATVAAAATPPAASAKAFNLNDVSSFS 1967
            ...::..     ..|.:|.|:....|:..|                          .|.: .|..
pombe  1822 ESGKKGGAKGWFSKLLRRDESKDQPTVYKA--------------------------KLGE-KSHL 1859

  Fly  1968 STNKRHQATSSSNNRSSSNQAA--------------AAAAATKAAAIATVPAAPNQLLSCRKSNS 2018
            ..:|..:...:.:....|||||              .:||.|.|...|..||....:
pombe  1860 HYDKELKRWVNDDGSDLSNQAAPPPPPPMALPKAGPPSAAPTSALPPAGPPAGATAI-------- 1916

  Fly  2019 QNSPYLATPKTLTTPTRFIAAKAATVTATPTAPATSTTTS------------------------T 2059
            ..:|.:..|..||.     ...|..:::.|.||.:..:.:                        |
pombe  1917 SGNPGMPAPVPLTG-----KETAVPLSSMPNAPPSVASNAKLPPASNNRKVDPLEDILQAMPPPT 1976

  Fly  2060 TIGARGSSTKR 2070
            |..|||.::||
pombe  1977 TRKARGKTSKR 1987

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec16	NP_001285158.1	DUF4813	<279..379	CDD:435117
		ACE1-Sec16-like	1371..1631	CDD:187750	63/294 (21%)
sec16	NP_594985.1	rad2	<85..>550	CDD:273166	58/297 (20%)
		Sec16	1093..>1185	CDD:432885	24/122 (20%)
		Sec16_C	1266..1566	CDD:432884	69/340 (20%)
		PHA03378	<1895..>1975	CDD:223065	15/92 (16%)