DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Sec16 and Sec16a

DIOPT Version :9

Sequence 1:NP_001285158.1 Gene:Sec16 / 32209 FlyBaseID:FBgn0052654 Length:2326 Species:Drosophila melanogaster
Sequence 2:XP_006497973.2 Gene:Sec16a / 227648 MGIID:2139207 Length:2403 Species:Mus musculus


Alignment Length:2593 Identity:543/2593 - (20%)
Similarity:849/2593 - (32%) Gaps:838/2593 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 HNNAPWLPPHQQQQQQAPQQ-HPTPQQQHAMPQQQQTLPAQQQQQQVYASQMFQQHQPNYWPEDQ 66
            |..:|:||..|...|..|.| .|.|..||..|.    |....|...:.|:.:  .|.|.  |...
Mouse   197 HAASPFLPQPQMPGQWGPAQGGPQPSYQHHSPY----LEGPVQNMGLQAASL--PHFPP--PSSL 253

  Fly    67 HQ----QQQQPQSLNYNNYFPGQQQQHPMQQQQLPPQQQLPPQQQQPTQQQHTIQQQLYY----- 122
            ||    :...||:....:...|:..:...||.:..|....||        :||.:|....     
Mouse   254 HQGPGHESHAPQTFTPASLASGEGNEIVHQQSKNHPLSSFPP--------KHTFEQNSRIGNMWA 310

  Fly   123 --PTQQQPQV-------PAPAEPALDSFDNNNS-----------------GGGGGGGRSDGWGDW 161
              ..:|.|.|       ||...|    |...||                 .....|..|..:  .
Mouse   311 SPELKQNPGVNKEHLLDPAHVNP----FTQGNSPENQAHHPPVAATNHALQEAASGALSMFF--Q 369

  Fly   162 GDWNDNSNNNNSN--GTDGLLEPTGQLLEDSFNVQS---------SQGSWQAFATSNNVNNNGEL 215
            |:..:|..|.:|.  |.|      .:|..|||:..|         :.|.:|||            
Mouse   370 GEETENEENLSSEKAGLD------KRLNLDSFSSTSRLGHPPPPGASGVYQAF------------ 416

  Fly   216 PPPANPQSTSLQQ---QPLNQQSIPL-LHQQPQSPP-------------ELGQEPELDAIVPPQA 263
              |..|.|.:.|:   ||...||:.: |.:|...||             .....|:.:.:...:.
Mouse   417 --PRGPSSEAAQEGDAQPYFSQSVGVRLDKQSTVPPANDAWGDVPGTGTRCASGPQCENVENLEF 479

  Fly   264 FQNQ--------------------------PPTAAPPPTSLT-SFSAQMTAVGSPIYAVGASSAH 301
            .|||                          |..:.|....|| .....:.|..:|::.....|..
Mouse   480 VQNQEVLPRETLSVDPFPLSDQIRYGPLPGPAASRPATVGLTRGGGLNLEAPDTPLHPTRPDSVS 544

  Fly   302 SAGVGASPAPPTGVVAPPAHLAG------IGAPPAHLAGVGASPAPSALVGASPAPIIG------ 354
            |:....|...|.| .|.|..|.|      :|......:|.......|:.||.....:.|      
Mouse   545 SSYSSHSHRSPPG-SARPQELVGTFIQQEVGKLEDDTSGSFFKQIDSSPVGGETDEVTGSQNCCS 608

  Fly   355 -VGAPPVGAPP---------------------VGAPPADA--------------------TTIAP 377
             :..|...:||                     ||..|.:|                    ..:||
Mouse   609 SLSQPSTPSPPKPTGVFQTSANSSFEPVKSHLVGVKPVEADRANMVVEVRGTQYCPKKRRAAVAP 673

  Fly   378 PAAL------PP-----------------------SIVPSSGSNPFKRSTGL-NKRVNIMADPAA 412
            |.|.      ||                       .:|.::...|......: :||.:..|....
Mouse   674 PDATSGNLEQPPDNMETPCAPQACPLPLSTTGEAGQLVSNTAGTPLDTVRPVPDKRPSARAQGPV 738

  Fly   413 GAPSP--------------------PAPAAAIAPVAP-----------------------VAPI- 433
            ...||                    ||..|...||.|                       |.|: 
Mouse   739 KCESPATTLWAQNELPDFGGNVLLAPAAPALYVPVKPKPSEVVHHPEKGMSGQKAWKQGSVPPLQ 803

  Fly   434 -------------PPPADQLFGMPAEAHGEGFNLIAAPPVEASLGTP-----------LSAPIPA 474
                         ||...:...:|.:|.....:|:::||.|:....|           |:.||..
Mouse   804 NQDPPGASENLENPPKVGEEEALPVQASSGYASLLSSPPTESLHNQPVLIAQPDQSYNLAQPINF 868

  Fly   475 PI--------------------------------PVPNASLYASPA-----------VPQAFAHL 496
            .:                                |...|:|...||           :||..|..
Mouse   869 SVSLLNPNEKNQSWGDAVVGERSIVSNNWALGGDPEERAALSGVPASAVTGASLPSSIPQNCAPQ 933

  Fly   497 EPDNQEVLSAPNDERAQYL---------QTSHLSEQLGEGE-----ADQDAGLLPPPGLSRLVLG 547
            ...:.|::::   :.|.:|         |:.|.:.:.|..|     |...:.:|.||..|.||..
Mouse   934 GSGSSEMIAS---QSASWLVQQLSPQTPQSPHPNAEKGPSEFVSSPAGNTSVMLVPPASSTLVPN 995

  Fly   548 QPEL-DSQQQRQVTGA-------TEQPPLNVAQAAALHMQERRADGEDTSDGEQQVRNIQTPPRR 604
            ..:. .|..|.:..||       |.:.|:             |......|||....:.:...||:
Mouse   996 SNKAKHSSNQEEAVGALDFTLNRTLENPV-------------RMYSPSPSDGPASQQPLPNHPRQ 1047

  Fly   605 VVTGVETNAPSLREQ----REVVLDGEN---LE--DREAIPP---------------PTLAELPT 645
                   :.|.|..|    ::|..|.::   ||  ..|.:||               |:..|.|.
Mouse  1048 -------SGPGLHNQDHFYQQVTKDAQDQHRLERAQPELVPPRPQNSPQVPQASCPEPSNPESPP 1105

  Fly   646 TSVHHNILPDEAEQLHHNNPPQAMTPLNA----QQPHQQQSTLQQQHQQHSTTQQEKKRAAVGRR 706
            |.       .::|.|  ..||.:...:|.    .||.|..|.        |.|.....:|||   
Mouse  1106 TQ-------GQSESL--AQPPASPASVNTGQLLPQPPQASSA--------SVTSTNSSQAAV--- 1150

  Fly   707 TTASLDLESDESDEFLQSERERDRERERRDLMEERHSRGRSHSHYPYEGETEDSVRGAAHHETKS 771
            .:..|.|.....:.|..:.::.......|.|.:...|:      ||....::.......:.:...
Mouse  1151 RSEQLWLHPPPPNTFGPAPQDLASYYYYRPLYDAYQSQ------YPSPYPSDPGTASLYYQDMYG 1209

  Fly   772 LRETHHKRNHDSARSRRHQDPKVERERERDRERDRTWRRRSNKYHSGGEDPDRSYDHSRRYNNSN 836
            |.|..: |.:||:.|       ...|..|..|.:|...|.|  ::|....|.:.|......:.|.
Mouse  1210 LYEPRY-RPYDSSAS-------AYAENHRYSEPERPSSRAS--HYSDQLAPRQGYPEGYYNSKSG 1264

  Fly   837 YEGESD------NPEYNHMGDAELD---GSGGRSSKTSRHRRSAAEEDFDDYERERNRSRRSTKP 892
            :...||      :.:|::...:..|   ||..|..:| ..||...:.:.|.|.::          
Mouse  1265 WSSHSDYYANYYSGQYDYGDPSRWDRYYGSRLRDPRT-WDRRYWYDSEHDPYRKD---------- 1318

  Fly   893 QSSAEKSRSSGGRRNYENSGRSARADDGRRRYQDQRNPGAQYPVSATGYVPYGMYEQMSRNPQVY 957
                          :|..|.|..:.|| ..|| |.|..|:....:.....|||  |:..|     
Mouse  1319 --------------HYAYSDRPEKCDD-HWRY-DPRFTGSFDDDAEIHRDPYG--EEADR----- 1360

  Fly   958 ADMYAKFYGQMINSMNAAVSAAASKGGVPAGAGVIPGLMPSAVPVSAAQLVAATSGGSVSGSSEA 1022
                     :.|:|.::|.|.                                            
Mouse  1361 ---------RSIHSEHSARSL-------------------------------------------- 1372

  Fly  1023 AMLRERERYTHAYITQANEFHRHQYKELIYQQQQQQQQQQQQQQQREDHLNSSFSVAEDNASFYG 1087
                   |.||:..::.:....|.::..||               |..|:.        ..||..
Mouse  1373 -------RSTHSLPSRRSSLSSHSHQSQIY---------------RSHHVT--------GGSFEA 1407

  Fly  1088 SHGGGSIYNQYQSYPLSSARSLSNLNGDGRNSRCGPYYAGSECGLDIRAAADAAPSTYGGVAGTA 1152
            .|..||.:..|     :.....||.:|                       |...|. |...|.|:
Mouse  1408 PHAPGSFHGDY-----AYGTYASNFSG-----------------------AHGFPE-YSYPADTS 1443

  Fly  1153 GPVTNTAVARPPRRRTPLQFSRPHLVASYAM-SLLLKVKPKYAGRGR--------LRNDVEVAPP 1208
            .|......:||   .:|.:|:.||:.|.:.. ..||||.|.....|:        |...::..|.
Mouse  1444 WPAVEQVPSRP---TSPEKFTVPHVCARFGPGGQLLKVIPNLPSEGQPALVEIHSLETLLQHTPE 1505

  Fly  1209 RIRDGTSSLLRMYPGPLQGRKLHKDKIISFCKEQIRLGPTKGCTALYATQKKPQGSVTKYRASHA 1273
            :      ..:|.:||||.....||..:|:|.:.:             ||:.....|:.. :.|.:
Mouse  1506 Q------EEMRSFPGPLGKDDTHKVDVINFAQNK-------------ATKCLQNESLID-KESAS 1550

  Fly  1274 LMWHLLILLLRQNGYIADTDVGDLLLENQQ------EYPYDPSEFEAENEPDADAEQDAAAPADK 1332
            |:|..:|||.||||.:..||:.:|||.:.:      :.|.:.:..:..||.....|::.:..|..
Mouse  1551 LLWKFIILLCRQNGTVVGTDIAELLLRDHRTVWLPGKSPNEANLIDFTNEAVEQVEEEESGEAQL 1615

  Fly  1333 TVDSDLDSESAAGVTPAEPLAAGAATSSINGADAANAATPLSEQAATDKFRSYVLRGNVEEALQW 1397
            :..:|                :...|:|:           |.::  |::||..:|.|..::||:.
Mouse  1616 SFLTD----------------SQTVTTSV-----------LEKE--TERFRELLLYGRKKDALES 1651

  Fly  1398 ATDNGLWTHAFFLALYEDRYALTDVAQKFLNRAIKANDPLQTLYQMKSCHTPACVSQLRDEQWGD 1462
            |..||||.||..||...|......|..:|.| ::..||||||:||:.|...||..:...||:|||
Mouse  1652 AMKNGLWGHALLLASKMDSRTHARVMTRFAN-SLPINDPLQTVYQLMSGRMPAASTCCGDEKWGD 1715

  Fly  1463 WRSHLSILVTNKSRQPEYDRSSVVALGDTLFQRGDIYAAHFCYLVAQEEFGRYDSSATELTTLTA 1527
            ||.||:::::|.:...:.:..::..:||||..:|.:.|||||||:||..||.|    |:.||   
Mouse  1716 WRPHLAMVLSNLNNNMDVESRTMATMGDTLASKGLLDAAHFCYLMAQVGFGVY----TKKTT--- 1773

  Fly  1528 NVPRLILLGSSHYKHFNEFASNEAIIMTEIYEYARSLFDPKFSIAHFQHYKFLLATRILDYGQHF 1592
               :|:|:||:|...|.:||:||||..||.||||:||.....|:.:||.:||:...|:.:.|...
Mouse  1774 ---KLVLIGSNHSLPFLKFATNEAIQRTEAYEYAQSLGAHTCSLPNFQVFKFIYLCRLAEMGLAT 1835

  Fly  1593 RCTNYLEQIARHIELKPESYDSNFIQRVCGLAERLRYHDPILINR---VSFASPPNATSKDSAAA 1654
            :..:|.|.||:.:..:|.:|....|.::..:|.:||..||.|..:   .||..|           
Mouse  1836 QAFHYCEVIAKSVLTQPGAYSPVLISQLTQMASQLRLFDPQLKEKPEEESFVEP----------- 1889

  Fly  1655 EEKAWLRQLRSLAYVQPQQEQLQQ-----LQQNQQVQQ---------EQND---IDQQFAEVNKQ 1702
               |||.||      |..:.|:|:     .|...:.||         ||:|   ::||       
Mouse  1890 ---AWLVQL------QHVERQIQEGTVLWSQDGTEPQQCRITSGSEVEQSDGPGLNQQ------- 1938

  Fly  1703 FRELNMQYESNSNMENTLQP------QLPPVDQQPPQQQQQVLSESYQQPTQQYYEPPPQAPTES 1761
               ...|.::...|.:| :|      .||...|..|..|...||.....|.     |..:.|.|.
Mouse  1939 ---AGPQADNPLLMPST-EPLMHGVQLLPTAPQTLPDGQPAHLSRVPMFPV-----PMSRGPLEL 1994

  Fly  1762 DP-YGQ-----GQPSYYDPNAGQLH----YDPNAAQHQYDQQQPQPQPTPSYGQIEPGTEA-YQP 1815
            .| ||.     |.|.....:...||    ..|.....|.....||...:|....:..|:.. :.|
Mouse  1995 SPAYGPPGSALGFPESSRSDPAVLHPGQALPPTTLSLQESGLPPQEAKSPDPEMVPRGSPVRHSP 2059

  Fly  1816 --------GQATADPAAVPSGYGYD---YW-----SGTQQPPY-GDEPNENQAALKDEEEEDEEQ 1863
                    |::.|||.:..:....:   .|     |.|:.|.. .|...:..|....:|.::.::
Mouse  2060 PELSQEEFGESFADPGSSRTAQDLETSPVWDLGSSSLTRAPSLTSDSEGKKPAQAVKKEPKEPKK 2124

  Fly  1864 DEQQILQY-----AKQQILQQTKQQQLQQEQHTRSNGAASINNRFKSNALKQERSSGSLRKRQEA 1923
            .|....::     ..:..|...|.:.:..::  :.|...::|                 ...:|.
Mouse  2125 TESWFSRWLPGKKRTEAYLPDDKNKSIVWDE--KKNQWVNLN-----------------EPEEEK 2170

  Fly  1924 SRTATIAAAAAAIAQITPATVAAAATPPAASAKAFNLNDVSSFSSTNKRHQATSSSNNRSSSNQA 1988
            ........:...:.|:.|   ...|.||.||...|      |..:...|.:.....|...:....
Mouse  2171 KAPPPPPTSFPRVPQVAP---TGPAGPPTASVNVF------SRKAGGSRARYVDVLNPSGTQRSE 2226

  Fly  1989 AAAAAATKAAAIATVPAAPNQLLSCRKSNSQNSPYLATPKTLTTPTRFIAAKAATV-----TATP 2048
            .|.|.|...|.:|.:| .|:.|........:..|...|......|....:...:|:     ::|.
Mouse  2227 PALAPADFFAPLAPLP-IPSNLFVPNPDAEEPQPADGTGCRGQAPAGTQSKAESTLEPKVGSSTV 2290

  Fly  2049 TAPATSTTTSTTIGARGSSTKRVYFNLPSTIAESEQEFEHELDYDEEMEEENSMALAQAKPNVHL 2113
            :||......|...|::|....|.     |:::...||.              |....|| |..|.
Mouse  2291 SAPGPELLPSKPDGSQGGELSRC-----SSLSSLSQEV--------------SRHFHQA-PGDHC 2335

  Fly  2114 -ARKPHIVFNGTYPIDMPLTQGQSQLKSNSYDPE---------ANADRGDLQRYRNYM 2161
             ...||   .|:.|...|     :||..|..:..         .||::.:|..||..:
Mouse  2336 PTGAPH---GGSVPFYNP-----AQLVQNWQNKNKSCLQCCGLGNAEQQELGTYRRLL 2385

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sec16NP_001285158.1 ACE1-Sec16-like 1371..1631 CDD:187750 99/259 (38%)
Sec16aXP_006497973.2 PHA03247 <2..291 CDD:223021 27/101 (27%)
PHA03247 <669..1241 CDD:223021 113/628 (18%)
ACE1-Sec16-like 1512..1874 CDD:187750 133/415 (32%)
PHA03247 <1934..2308 CDD:223021 76/418 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167841042
Domainoid 1 1.000 170 1.000 Domainoid score I3764
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001693
OrthoInspector 1 1.000 - - otm43920
orthoMCL 1 0.900 - - OOG6_105006
Panther 1 1.100 - - O PTHR13402
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
76.930

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