Protein Alignment Sec16 and sec-16A.2

DIOPT Version :9

• Sequence 1: NP_001285158.1
• Gene: Sec16 / 32209
• FlyBaseID: FBgn0052654
• Length: 2326
• Species: Drosophila melanogaster
• Sequence 2: NP_509400.3
• Gene: sec-16A.2 / 181084
• WormBaseID: WBGene00017419
• Length: 1632
• Species: Caenorhabditis elegans
• Alignment Length: 2166
• Identity: 401/2166 - (18%)
• Similarity: 671/2166 - (30%)
• Gaps: 799/2166 - (36%)

  Fly     8 WLPPHQQQ------QQQA--PQQHPTPQQQHAMPQQQQTLPAQQQQQQVYASQMFQQHQPNYWPE 64
            |.|..|||      ||.|  ||||..|||.   ||||..:|....|.   |.|.:||.    |.:
 Worm    43 WNPATQQQNNYYYHQQPAAPPQQHTNPQQP---PQQQYNVPTNSHQT---AEQNYQQQ----WAQ 97

  Fly    65 DQHQQQQQPQSLNYNNYFPGQQQQHPMQQQQLPPQQQLPPQQQQPTQQQHTIQQQLYYPTQQQPQ 129
            .|:|.|.|||          ..||..:..||:..|.|||..::.|..|.:| |||:     ||..
 Worm    98 QQYQNQAQPQ----------PPQQPSLSSQQIQHQPQLPKAKKAPKVQTNT-QQQV-----QQNF 146

  Fly   130 VPAPAEPALDSFDNNNSGGGGGGGRSDGWGDWGDWNDNSNNNNSNGTDGLLEPTGQLLEDSFNVQ 194
            .|.|  |.|
 Worm   147 NPTP--PVL-------------------------------------------------------- 153

  Fly   195 SSQGSWQAFATSNNVNNNGELPPPANPQSTSLQQQPLNQQSIPLLHQQPQSPPELGQEPELDAIV 259
                     .||....|        ..|.....||...||::   :|.....||..|       |
 Worm   154 ---------TTSQKPGN--------TQQDYYYSQQQHTQQNV---YQTNHVHPEETQ-------V 191

  Fly   260 PPQAFQNQPPTAA----PPPTSLTSFSAQMTAVGSPIYAVGASSAHSAGVGASPAPPTGVVAPPA 320
            ..||.|   |||.    |||               |:..||:            |||:..|.|..
 Worm   192 VAQALQ---PTAESTYFPPP---------------PVQQVGS------------APPSKEVTPER 226

  Fly   321 HLAGIGAPPAHLAGVGASPAPSALVGASPAPIIGVGAPPVGAPPVGAPPADATTIAPPAALPP-- 383
            |... .||..|:..|...|.|..|            ||...||.........|..||.||..|
 Worm   227 HFTA-AAPAPHVEQVALVPTPPTL------------APKSQAPNTAKKAEHLTVTAPIAAETPKT 278

  Fly   384 SIVPSSGSNPFKRSTGLNKRVNIMADPAAGAPSPPAPAAAIAPVAPVAPIPPPADQLFGMPAEAH 448
            .:.|:|..:.::::....:||
 Worm   279 KVTPTSSEDDWEKADMEVQRV-------------------------------------------- 299

  Fly   449 GEGFNLIAAPPVEASLGTPLSAPIPAPIPVPNASLYASPAVPQAFAHLEPDNQEVLSAPNDERAQ 513
                                                            |.:|:...:.|:...::
 Worm   300 ------------------------------------------------EDENKRQKAVPSTAVSE 316

  Fly   514 YLQTSHLSEQLGEGEADQDAGLLPPPGLSRLVLGQP---ELDSQQQRQVTGATEQPPLNVAQAAA 575
            ..:.|..|..||...:.||........:...:|..|   |.|.:::......:|.|
 Worm   317 KPEESRESSSLGGSWSQQDTEPSERSSVEPEILEHPVKSESDKEEKTPRVSMSEFP--------- 372

  Fly   576 LHMQERRADGEDTSDGEQQVRNIQTPPRRVVTGVETNAPSLREQREVVLDGENLEDREAIPPP-T 639
                                 |.:|.|..|...|.||                 |||:..|.. .
 Worm   373 ---------------------NHETTPTIVTMSVSTN-----------------EDRQKTPEAGN 399

  Fly   640 LAELPTTSVHHNILPDEAEQLHHNNPPQAMTPLNAQQPHQQQSTLQQQHQQHSTTQQEKKR---- 700
            |::  .||:..|......|.:..:.|.:.       :|.::.|...|.......|:.:||.
 Worm   400 LSQ--NTSIVLNTTDSPLEAIATSTPKEI-------KPEKRSSVSSQGTIGAEKTKAKKKNKDEA 455

  Fly   701 -AAVGRRT---TASLDLESDESDEFLQSER-ERDRERERRDLME---------ERHSRGRSHSHY 751
             :::.:|.   :.:.:...:.||..:.|.| :.:|...|....|         :|....|:.||.
 Worm   456 VSSMFKRPDQFSENGEASGNNSDSTMASGRPDFERGHARASYREYKKTYKEIIDRLKMMRTDSHR 520

  Fly   752 P-----------------------------YEGETEDSVRGAAHHETKSLRETHHKRNHDSARSR 787
            |                             ..|..:.......||........:|.:| ...|||
 Worm   521 PDFRPASKLANPLLAAAGLSRLHPAIRRESAGGRNDGRTSVPLHHSHSFTEHMYHDQN-GGRRSR 584

  Fly   788 -RHQDPKVERERERDRERDRTWRRRSNKYHSGGEDPDRSYDHSRRYNNSNYEGESDNPEYNHMGD 851
             ...||..               |.|::..:|.:..::||:|..::|:|          |.|
 Worm   585 VSRLDPNA---------------RPSSRQATGYQTANQSYNHYDQHNHS----------YQH--- 621

  Fly   852 AELDGSGGRSSKTSRHRRSAAEEDFDDYERERNRSRRSTKPQSSAEKSRSSGGRRNYENSGRSAR 916
                     .....|.|.||....||        :||:  |.|.........|:...|.|..|..
 Worm   622 ---------QQMQHRGRHSALGVPFD--------ARRT--PSSYIRTFSGEYGQEPQETSSISEN 667

  Fly   917 ADDG-------------------RRRYQDQRNPGAQYPVSATG---------YVPYGMYEQMSRN 953
            .|||                   ||.|.:.:....|.|:...|         :|...::.:::::
 Worm   668 EDDGDNVESDDELRGFNMERQHERRGYNNAQYQEVQCPIEEDGSALYYCGVVHVNMDIWRRITQS 732

  Fly   954 PQVYAD-------------MYAKFYGQMINSMNAAVSAAASKGGVPAGAGVIPGLMPSAVPVSAA 1005
            .|:.|:             .||..:.|...:::
 Worm   733 YQIPAEFNELKPIEKAAYIFYAVIHKQPCRNLD-------------------------------- 765

  Fly  1006 QLVAATSGGSVSGSSEAAMLRERERYTHAYITQANEFHRHQYKELIYQQQQQQQQQQQQQQQRED 1070
                             ...::...|.:.|..:.:......:|.....|....::|:::::..::
 Worm   766 -----------------TFRKQFNFYFYKYGMEGDSDDDALFKVCRTMQNHYIERQREKERANQN 813

  Fly  1071 HLNSSFSVAEDNASFYGSHGGGSIYNQYQSYPLSSARSLSNLNGDGRNSRCGPYYAGSECGLDIR 1135
            .:::.||   |:.|.    .||::|:......:...:|:........||.|       |..|:
 Worm   814 MMSTLFS---DDTSI----DGGNVYSLPNLSTVEPPKSIIAKRQSDMNSVC-------EESLN-- 862

  Fly  1136 AAADAAPSTYGGVAGTAGPVTNTAVARPPRRRTPLQFSRPHLVASYAM-SLLLKVKPKYAGRGRL 1199
                            |..:.|..         ||:|:.||...:.:. ..::.::|..:....:
 Worm   863 ----------------AYDIYNNG---------PLKFTCPHSFMNISTGGQIISIRPDQSISAVV 902

  Fly  1200 RNDV-----EVAPPRIRDGTSSLLRMYPGPLQGRKLHKDKIISFCKEQIRLGPTKGCTALYATQK 1259
            .:|:     :|...:::|...:    :.|||...:.....:..:..:||. .......|:    :
 Worm   903 FDDIKSVLKDVPTLQVKDAAMT----FKGPLIPHQSAPHTVRLYITKQIE-NIKNSAVAI----E 958

  Fly  1260 KPQGSVTKYRASHALMWHLLILLLRQNGYIADTDVGDLLLENQQEYPYDPSEFEAENEPDADAEQ 1324
            .|:.:..   ....|:|.||..:::|.|.|...|:.:||.:...:    |.:.||..:
 Worm   959 NPEANDV---VESLLIWQLLETMVKQQGNITGPDIAELLAKVASQ----PVQIEAPPQ------- 1009

  Fly  1325 DAAAPADKTVDSDLDSESAAGVTPAEPLAAGAATSSINGADAANAATPLSEQAATDKFRSYVLRG 1389
                                                     .||.|..|::      |..::|.|
 Worm  1010 -----------------------------------------QANIAPALTQ------FTKFLLGG 1027

  Fly  1390 NVEEALQWATDNGLWTHAFFLA--LY-EDRYALTDVAQKFLNRAIKANDPLQTLYQMKSCHTPAC 1451
            :::||::.|..|||:..|..|.  |: .|...:..:..:||.....:| |:.||..:....:|..
 Worm  1028 HIDEAVESALRNGLFADALVLTRRLFPNDERRIEQIESRFLQTRSMSN-PVTTLVSVAKGESPPV 1091

  Fly  1452 VSQLRDEQWGDWRSHLSILVTN-KSRQPEYDRSSVVALGDTLFQRGDIYAAHFCYLV-------- 1507
            ::....:....|.:|.:|::.| ..|.|.  .:::..||..|.:|....||.||:||
 Worm  1092 LTNPPLDDHLSWGTHAAIILANLDQRGPA--MNTIYQLGRALAKRDYHSAADFCFLVCGVLGGTN 1154

  Fly  1508 ---------AQEEFGRYDSSATELTTLTANVPRLILLGSSHYKHFNEFASNEA------------ 1551
                     .:|::.|:      ::.:.:::|                 .||:
 Worm  1155 PFEPIATPEGEEDYRRH------ISLVNSDIP-----------------DNESNPKCQYGFLLTD 1196

  Fly  1552 IIMTEIYEYARSL----FDPKFSIAHFQHYKFLLATRILDYGQHFRCTNYLEQIARHIELKPESY 1612
            :..|||::||..|    ..|......:|..:...|..:.::|.:.....|..::||.|......:
 Worm  1197 LHATEIFDYALRLKADRESPLTKSVEYQTARIKYAKLLANHGFNTDAYRYCTEVARAIWNNLYLF 1261

  Fly  1613 DSNFIQRVCGLAERLRYHDPILINRVSFASPPNATSKDSAAAEEKAWLRQLRS-----LAYVQPQ 1672
            .::.:..:|.|||.|:|           |:..|.:        |..|:..||:     ..|....
 Worm  1262 KADDLLELCDLAESLQY-----------AASVNPS--------ESQWIHDLRTTVQAGFVYTPQP 1307

  Fly  1673 QEQLQQLQQNQQVQQEQNDIDQQFAEVNKQFRELNMQYESNSNMENTLQPQLP--PVDQQPPQQQ 1735
            .:.::.|:                   ||....::..|:..||.::  .|::|  ||...|..|.
 Worm  1308 TQTVKHLE-------------------NKPVPSVHQGYDLQSNAQD--DPEVPREPVQHVPITQN 1351

  Fly  1736 --QQVLSESYQQPTQQYYEPPPQAPTESDPYGQGQPSYYDPNAGQLHYDPNAAQHQYDQQ----- 1793
              ..|.:.|...||.|..:|....|.::..|.: :|.:..|..     .|:..|.|:.||
 Worm  1352 VIDPVPTHSAFTPTIQPKDPELSHPPQNQVYRE-EPPHIPPTP-----TPSVHQEQHYQQFDQSF 1410

  Fly  1794 -QPQPQPTPSYGQIEPGTEAYQPGQATADPAAVPSGYGYDYWSGTQQPPYGDEP----NENQA-- 1851
             |...|.....|.:.|...:..|....:.|..:|.         .|..|...:|    .||||
 Worm  1411 SQSLTQQAQEDGFMTPPDYSDGPLTMASSPPTLPP---------VQSVPVSSKPAPPSAENQAQN 1466

  Fly  1852 ---ALKDEEEEDEEQDEQQILQYAKQQILQQTKQQQLQQ----------EQHTRSNGAASINNRF 1903
               ..:..:|:.:|..::...|....:.:|.|.|..:|:          |....|....|..|::
 Worm  1467 STSPQQPTQEQGQETQDRNPDQGGWLKSIQSTVQNTVQKATGRNPMNLPEDRNPSIVWDSTQNKY 1531

  Fly  1904 KSNALKQER----------------SSGSLRKRQEASRTATIAAAAAAIAQITPATVAAAATPPA 1952
            ....::||.                ..|.||..:.|||.|.:...:::.:| .||.:.|.| ||.
 Worm  1532 VGAGVEQEPVAPPPPMAQAGPAPPVGGGGLRAARGASRYARVGGTSSSASQ-APAGMMAPA-PPT 1594

  Fly  1953 AS-----AKAFNLND-VSSFS 1967
            |:     |...|.|| |..||
 Worm  1595 ANFGFIPAPVDNDNDSVDPFS 1615

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec16	NP_001285158.1	ACE1-Sec16-like	1371..1631	CDD:187750	62/296 (21%)
sec-16A.2	NP_509400.3	ACE1-Sec16-like	925..1280	CDD:187750	85/457 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166437
Domainoid	1	1.000	54	1.000	Domainoid score	I7514
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I3096
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001693
OrthoInspector	1	1.000	-	-		otm14472
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13402
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1306
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.110