Protein Alignment Sec16 and sec-16A.1

DIOPT Version :10

• Sequence 1: NP_001285158.1
• Gene: Sec16 / 32209
• FlyBaseID: FBgn0052654
• Length: 2326
• Species: Drosophila melanogaster
• Sequence 2: NP_499022.1
• Gene: sec-16A.1 / 176289
• WormBaseID: WBGene00013985
• Length: 1232
• Species: Caenorhabditis elegans
• Alignment Length: 1437
• Identity: 272/1437 - (18%)
• Similarity: 470/1437 - (32%)
• Gaps: 496/1437 - (34%)

  Fly   812 SNKYHS------GGEDPDRSYDHSRRYNNSNYEGESDNP--------------EYNHMGDAELDG 856
            :|.|::      ||:|...|.:|||. ..|..:.:...|              :.|..|....:|
 Worm    28 NNPYNASPPSSRGGDDDASSVNHSRP-RRSRLDNDIPQPRRPILIQPARPVSQKSNRQGTGMSNG 91

  Fly   857 SGGRSS------KT-SRHRRSAA---EEDF-------------DDYERER-------NRSRRSTK 891
            |.|.:|      :| ||:.::::   .|.|             .||...|       |..|...:
 Worm    92 SRGLNSTFNGYDRTYSRYHQNSSRGPSEGFSGAPSARNASGYASDYANSRAGVGLLPNNHREPVR 156

  Fly   892 PQS-SAEKSRSSGGRRN---YENSGRSARA----------DDGRRRYQDQRNPGAQYPVSATGYV 942
            |:| :||:..::...||   |: ||.|.:.          ::.|..|.:.|..|::   |.|..:
 Worm   157 PRSTAAERYANASSMRNGFVYD-SGESDKTSEELEEDEEEEEVRNFYMEGRAQGSR---SVTNTL 217

  Fly   943 PYGMYEQMSRNPQVYADMYAKFYGQMINSMNAAVSAAASKGGVPAGAGVIPGL---MP------S 998
            ...:|...|.         :.:||.                 |..|:.::..:   ||      .
 Worm   218 ASEVYNSESE---------SYYYGV-----------------VKLGSAIVDHVFRTMPPPEKYYK 256

  Fly   999 AVPVSAAQLV--AATSGGSVSGSSEAAMLRERERYTHAYITQA-------------NEFHRHQYK 1048
            ..|:.....|  .|.:....:...|..::..||.|::.....:             .||...|.:
 Worm   257 MPPIDRVAYVFYCAVNNKPYNNIDEFHVIFNREFYSYRGYGDSKDLALFKVCKRMQEEFSLKQLE 321

  Fly  1049 --ELIYQQQQQQQQQQQQ--------QQQREDHLNSSFSVAEDNASFYGSHGGGSIYNQYQSYPL 1103
              .|.|::.:|:..:.::        :::.|..||.|
 Worm   322 ADRLAYEKARQEAAESEKLDFNQHKIEEREEPKLNIS---------------------------- 358

  Fly  1104 SSARSLSNLNGDGRNSRCGPYYAGSECGLDIRAAADAAPSTYGG------VAGT----AGPVTNT 1158
            .....|||          ||        |...:....|....||      .|||    .|.|.:|
 Worm   359 QPEEVLSN----------GP--------LHYHSCLQFATIGVGGKLVIIKPAGTIDSITGHVLST 405

  Fly  1159 AVARPPRRRTPLQFSRPHLVASYAMSLLLKVKPKYAGRGRLRNDVEVAPPRIRDGTSSLLRMYPG 1223
            :.......:|.|.|...                    .|::...|:               .:.|
 Worm   406 SSVHVDDLKTFLHFDEQ--------------------SGKVIESVQ---------------NFKG 435

  Fly  1224 PLQGRKLHKDKIISFCKEQIRLGPTKGCTALYATQKKPQGSVTKYRASHALM-WHLLILLLRQNG 1287
            ||...:.....:..:.:.||        .||  .|.:..|.|.|.....||: |.||.::::|:|
 Worm   436 PLIAGQTPTHSVRLYIQRQI--------DAL--RQIRNAGDVKKSEVVDALLVWQLLEIMVQQHG 490

  Fly  1288 YIADTDVGDLLLENQQEYPYDPSEFEAENEPDADAEQDAAAPADKT-VDSDLDSESAAGVTPAEP 1351
            .:...||..||....:|.                        .:|| :.|:..|||.
 Worm   491 RVTGPDVATLLTNASEEL------------------------GEKTGISSNGTSESG-------- 523

  Fly  1352 LAAGAATSSINGADAANAATPLSEQAATDKFRSYVLRGNVEEALQWATDNGLWTHAFFL--ALY- 1413
                                  |:..|.::|..|:|.|::.||::.|..:||:..|..|  .|:
 Worm   524 ----------------------SKFEAKERFNKYLLGGHINEAVESAITDGLYADAMTLIRRLHP 566

  Fly  1414 EDRYALTDVAQKFLN-RAIKANDPLQTLYQMKSCHTPACVSQLRDEQWGDWRSHLSILVTNKSRQ 1477
            .|...:.::..:|:| |:|  :||..||..:.|...|..::....:...:|:.|.:|::.|.:.|
 Worm   567 NDAKKIEEIEARFMNLRSI--DDPFATLVAVSSDQPPPILTNSAFDDDNNWKRHAAIVLANLNSQ 629

  Fly  1478 PEYDRSSVVALGDTLFQRGDIYAAHFCYLV--------------------AQEEFGRYDSSATEL 1522
            ..  ..::..||..|.:|....||.||.||                    :::..|...|.:..|
 Worm   630 TA--MQTIYHLGLLLAKRERNCAADFCLLVVCILAGYDPFIPVAHDGDETSRKHIGLVHSGSNLL 692

  Fly  1523 TTLTANVPRLILLGSSHYKHFNEFASNEAIIMTEIYEYA-----RSLFDPKFSIAHFQHYKFLLA 1582
            ..:..      |.|::.:...:..|       |:|::||     .::..|......:|..:...|
 Worm   693 NRVDG------LSGTAGFSFTDLHA-------TDIFDYALRLGNNNVDSPLAKSIDYQLARIEYA 744

  Fly  1583 TRILDYG----QHFRCTNYLEQIARHIELKPESYDSNFIQRVCGLAERLRYHDPILINRVSFASP 1643
            .::..:|    ..||   |..::||.:.:...::|.|.:..:|.|||.|:|        ::.|:|
 Worm   745 KKLSSFGGFATDAFR---YCTEVARSLWMYVAAFDKNAMFDLCDLAESLQY--------MAAATP 798

  Fly  1644 PNATSKDSAAAEEKAWLRQLRSLAYVQPQQEQLQQLQQNQQVQ---------------------- 1686
                       :|..|:..:|.:....|.||..|.:.|.|.|:
 Worm   799 -----------DESGWITTMRGMLGAAPVQESQQHVPQPQPVENKSISSEAKKWHDEHQAPLEIG 852

  Fly  1687 ----QEQND--IDQQFAE----------VNKQFRELNMQYESNSNM-------------ENTL-- 1720
                |:.||  :::..|.          |.:...|.....:|:|::             .:||
 Worm   853 SRNDQQHNDKTVEKPIAPGRASLPPPTLVTESSSESTFTDKSDSSVTVAASASRTSTLTSSTLPP 917

  Fly  1721 QPQLPPVDQQ----PPQQQQQVLSE-------SYQQPTQQYYEPPPQAPTESDPYGQGQPSYYD- 1773
            .|.||...::    ||...:.|:.|       ....||.....||...|....|.....|...|
 Worm   918 PPSLPKTIEKPISTPPPISKNVVPEMTPPAIVKPPMPTLSMPIPPVSTPIMVSPQPIPIPKPVDA 982

  Fly  1774 -----------------PNAGQLHYDPNAAQHQYDQQQPQPQPTPSYGQ-IEPGTEAYQPG---- 1816
                             |.:.|..|.|...     ..||...|.|::.. ..|......|.
 Worm   983 SIAKSPRSELDDLWDTSPPSNQTSYPPAPR-----NIQPSYSPAPNFANPTAPSVPTPPPAVSSA 1042

  Fly  1817 ----QATADPAAVPSGYGYDYWSGTQQPPYGDEP-----NENQA------ALKDEEEEDEEQDEQ 1866
                |||...|::|:       :.|..||...:.     ||.:|      ::|::..:......|
 Worm  1043 PVLQQATLGQASIPN-------AKTTAPPVPQKQPELALNERKASKGWFGSIKEKVIKSIPSANQ 1100

  Fly  1867 QIL-QYAKQQILQQTKQQQ-----LQQE-----------QHTRSNGAASINNRFKSNALKQERSS 1914
            .|| ..:|..|:....|::     :::|           .|....|..|  |:..:|:|:..||.
 Worm  1101 MILPDDSKPSIVWDPVQKRYVGAGVEEEVVAAPPPVMSAPHLMGGGPDS--NKSSTNSLRSARSG 1163

  Fly  1915 GSLRKRQEASRTATIAAAAAAIAQITPATVAAAATPPAASAKAFNLNDVSSFSSTNKRHQATSSS 1979
            ...|..|....|:...|....:..:.|.|:..:.:...|..:..:...|..||.     :.|:.|
 Worm  1164 VGSRYLQSGMATSQAPAMDTGMPPMMPPTMPMSFSFMPAPTEDDSSEYVDPFSG-----EPTAPS 1223

  Fly  1980 NNRSSSN 1986
            .:.|..|
 Worm  1224 ESLSKQN 1230

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec16	NP_001285158.1	DUF4813	<279..379	CDD:435117
		ACE1-Sec16-like	1371..1631	CDD:187750	67/292 (23%)
sec-16A.1	NP_499022.1	ACE1-Sec16-like	433..794	CDD:187750	96/452 (21%)
		PHA03247	<867..1073	CDD:223021	40/217 (18%)
		Herpes_BLLF1	<941..>1216	CDD:282904	54/288 (19%)