DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sec16 and CRYZL2P-SEC16B

DIOPT Version :9

Sequence 1:NP_001285158.1 Gene:Sec16 / 32209 FlyBaseID:FBgn0052654 Length:2326 Species:Drosophila melanogaster
Sequence 2:NP_001343434.1 Gene:CRYZL2P-SEC16B / 111240474 HGNCID:53757 Length:1061 Species:Homo sapiens


Alignment Length:1344 Identity:324/1344 - (24%)
Similarity:486/1344 - (36%) Gaps:416/1344 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   820 EDPDRSY---DHSRRYNNSNYEGESDNPEYNHMGDAELDGSGGRSSKTSRHRRSAAEEDFDDYER 881
            :||||.:   .|.|...:|.:.||..:...::.|..:                 ..:|...|:::
Human    21 KDPDRGFRRDGHHRPVPHSWHNGERFHQWQDNRGSPQ-----------------PQQEPRADHQQ 68

  Fly   882 ERNRSRRS---TKPQSSAEKSRSSGGRRN-------YENSGRSARADDGRRRY------------ 924
            :.:.:.|.   .:|.|..:  ...||.||       ||||.:|.::...|..|            
Human    69 QPHYASRPGDWHQPVSGVD--YYEGGYRNQLYSRPGYENSYQSYQSPTMREEYAYGSYYYHGHPQ 131

  Fly   925 --QDQRNPGAQYPVSATGYVPYGMY-EQMSRNPQVYADMYAKFYGQ-----MINSMNAAVSAAAS 981
              |::|.|..:.|     |:.:..| ||...:...|.:.::.|...     ..||.|....:.||
Human   132 WLQEERVPRQRSP-----YIWHEDYREQKYLDEHHYENQHSPFGTNSETHFQSNSRNPCKDSPAS 191

  Fly   982 KGGVPAGAGVIPGLMPSAVPVSAAQLVAATSGGSVSGSSEAAMLRERERYTHAYITQANEFHRHQ 1046
            ..|......:.||           .|:|.......|.:||:.:|                     
Human   192 NSGQEWPGELFPG-----------SLLAEAQKNKPSLASESNLL--------------------- 224

  Fly  1047 YKELIYQQQQQQQQQQQQQQQREDHLNSSFSVAEDNASFYGSHGGGSIYNQYQSYPLSSARSLSN 1111
                               ||||..|:||                        ||.||..     
Human   225 -------------------QQRESGLSSS------------------------SYELSQY----- 241

  Fly  1112 LNGDGRNSRCGPYYAGSECGLDIRAA-------ADAAPSTYGGVAGTAGPVTNTAVARPPRRRTP 1169
                                  ||.|       |.||.|.......:|||            :.|
Human   242 ----------------------IRDAPERDDPPASAAWSPVQADVSSAGP------------KAP 272

  Fly  1170 LQFSRPHLVASYAMSLLLKVKPKYAGRGRLRNDVEVAPPRIRDGTSSL----------------- 1217
            ::|..||:..|:...            |:|   |.|.|....||.::|                 
Human   273 MKFYIPHVPVSFGPG------------GQL---VHVGPSSPTDGQAALVELHSMEVILNDSEEQE 322

  Fly  1218 -LRMYPGPLQGRKLHKDKIISFCKEQIRLGPTKGCTALYATQKKPQGSVTKYRASHALMWHLLIL 1281
             :|.:.|||....:||..|::||:::          |..:.:.:..||     ...||:|.||:|
Human   323 EMRSFSGPLIREDVHKVDIMTFCQQK----------AAQSCKSETLGS-----RDSALLWQLLVL 372

  Fly  1282 LLRQNGYIADTDVGDLLLEN---QQEYPYDPSEFEAENEPDADAEQDAAAPADKTVDSDLDSESA 1343
            |.||||.:..:|:.:||:::   .::|...|......|..|.|                      
Human   373 LCRQNGSMVGSDIAELLMQDCKKLEKYKRQPPVANLINLTDED---------------------- 415

  Fly  1344 AGVTPAEPLAAGAATSSINGADAANAATPLSEQAATDKFRSYVLRGNVEEALQWATDNGLWTHAF 1408
                  .|:.:....:.:.|....:..||..   ..:||...:..|..:|||:||..|.||.||.
Human   416 ------WPVLSSGTPNLLTGEIPPSVETPAQ---IVEKFTRLLYYGRKKEALEWAMKNHLWGHAL 471

  Fly  1409 FLALYEDRYALTDVAQKFLNRAIKANDPLQTLYQMKSCHTPACVSQLRDEQWGDWRSHLSILVTN 1473
            ||:...|....:.|...|.: .:..|||||||:|:.|...|...:...::||||||.||:::::|
Human   472 FLSSKMDPQTYSWVMSGFTS-TLALNDPLQTLFQLMSGRIPQAATCCGEKQWGDWRPHLAVILSN 535

  Fly  1474 KSRQPEYDRSSVVALGDTLFQRGDIYAAHFCYLVAQEEFGRYDSSATELTTLTANVPRLILLGSS 1538
            ::..||..:.::||:||||..:|.:.|||||||:|...||.|          |.....|:|||||
Human   536 QAGDPELYQRAIVAIGDTLAGKGLVEAAHFCYLMAHVPFGHY----------TVKTDHLVLLGSS 590

  Fly  1539 HYKHFNEFASNEAIIMTEIYEYARSLFDPKFSIAHFQHYKFLLATRILDYGQHFRCTNYLEQIAR 1603
            |.:.|.:||:.|||..|||:||.:.|..||..|..||.||.|.|:|:.|||...:..:|.|.|..
Human   591 HSQEFLKFATTEAIQRTEIFEYCQMLGRPKSFIPSFQVYKLLYASRLADYGLVSQALHYCEAIGA 655

  Fly  1604 HIELKPESYDSNFIQRVCGLAERLRYHDPILINRVSFASPPNATSKDSAAAEEKAWLRQLRSLAY 1668
            .:..:.||.....:..:..|||:|:..||:::.|       .:..:|.    |..||.|||    
Human   656 AVLSQGESSHPVLLVELIKLAEKLKLSDPLVLER-------RSGDRDL----EPDWLAQLR---- 705

  Fly  1669 VQPQQEQLQQLQQNQQVQQEQNDIDQQFAEVNKQFRELNMQYESNSNMENTLQPQLPPVDQQPPQ 1733
                    :||:  |:|..:..|.....::::.         ...:..|||........  |...
Human   706 --------RQLE--QKVAGDIGDPHPTRSDISG---------AGGTTTENTFYQDFSGC--QGYS 749

  Fly  1734 QQQQVLSESYQQPTQQ-YYEPPPQAPTESDPYGQGQPSYYDPNAGQLHYDPNAAQHQYDQQQPQP 1797
            :.....|..:..|.|. ..:|.||.|...      ||..|....|       |.|        ..
Human   750 EAPGYRSALWLTPEQTCLLQPSPQQPFPL------QPGSYPAGGG-------AGQ--------TG 793

  Fly  1798 QPTPSYGQIEPGTEAYQPGQATADPAAVPSGYGYDYW----------------SGTQQPPYGDEP 1846
            .|.|.|..    .|.:.||  |....||....|...|                ..|.|||.|.|.
Human   794 TPRPFYSV----PETHLPG--TGSSVAVTEATGGTVWEEMLQTHLGPGENTVSQETSQPPDGQEV 852

  Fly  1847 ---------------NENQA--ALKDEEEEDEEQDEQQILQYAKQQILQQTKQQQLQQEQHTRSN 1894
                           :|:.|  |.:||:|..:|.|:......|::..|...|       :||:|:
Human   853 ISKPQTPLAARPRSISESSASSAKEDEKESSDEADKNSPRNTAQRGKLGDGK-------EHTKSS 910

  Fly  1895 GAASINNRFKSNALK------QERSSGSLRKRQEASRTATIAAAAAAIAQITPATVAAAATPPAA 1953
            |.... :.|:|...|      .|.||.|....||..|.::...|...:: :||    :..:||  
Human   911 GFGWF-SWFRSKPTKNASPAGDEDSSDSPDSEQETPRASSPHQAGLGLS-LTP----SPESPP-- 967

  Fly  1954 SAKAFNLNDVSSFSSTNKRHQATSSSNNRSSSNQAAAAAAATKAAAIATVP----AAPNQLL--- 2011
                  |.|||:||    |.:........:||..|||.|.....:...:|.    :.|..||   
Human   968 ------LPDVSAFS----RGRGGGEGRGSASSGGAAAGAGVGGLSGPESVSFELCSNPGVLLPPP 1022

  Fly  2012 ----SCRKSNSQNSPYLATPKTLTTPTRFIAAKAATVTATPTAP 2051
                :....|....|.|.|..:|..|.|....:      .||.|
Human  1023 ALKGAVPLYNPSQVPQLPTATSLNRPNRLAQRR------YPTQP 1060

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sec16NP_001285158.1 ACE1-Sec16-like 1371..1631 CDD:187750 101/259 (39%)
CRYZL2P-SEC16BNP_001343434.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..86 15/81 (19%)
Required for endoplasmic reticulum localization 34..224 44/224 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 163..236 22/147 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 245..264 5/18 (28%)
Central conserved domain (CCD), required for localization to endoplasmic reticulum exit sites. /evidence=ECO:0000269|PubMed:21768384 271..713 160/538 (30%)
ACE1-Sec16-like 327..683 CDD:187750 133/412 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 711..733 2/30 (7%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 770..796 10/46 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 176 1.000 Domainoid score I3628
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 255 1.000 Inparanoid score I3188
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001693
OrthoInspector 1 1.000 - - otm41870
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR13402
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1306
SonicParanoid 1 1.000 - - X4658
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
88.090

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