Protein Alignment Sec16 and sec16a

DIOPT Version :9

• Sequence 1: NP_001285158.1
• Gene: Sec16 / 32209
• FlyBaseID: FBgn0052654
• Length: 2326
• Species: Drosophila melanogaster
• Sequence 2: XP_004916695.2
• Gene: sec16a / 100216253
• XenbaseID: XB-GENE-986385
• Length: 2362
• Species: Xenopus tropicalis
• Alignment Length: 2467
• Identity: 529/2467 - (21%)
• Similarity: 817/2467 - (33%)
• Gaps: 857/2467 - (34%)

  Fly     5 NAPW--LP------------PHQQQQQQAPQQHPTP--QQQHAMPQQQQT--LPAQQQQQQVYAS 51
            :|||  ||            |.|||...:|...| |  :..:..||..:|  .||||:.
 Frog   187 SAPWGSLPNAPPVSNQNFPLPVQQQSHNSPYYSP-PYLEVSNLAPQASETGAQPAQQRA------ 244

  Fly    52 QMFQQHQPNYWPED-------QHQQQQQPQSLNYNNYFPGQQQQ-----HPMQQQQLP------P 98
                  .|.|:|..       || ...||.|||..:|..||..:     .|.:.|:.|      |
 Frog   245 ------APGYYPPTSVSNPTFQH-SSSQPPSLNPTDYMHGQNPEQNWFNQPYKDQRHPPLPSSNP 302

  Fly    99 QQQLPPQQQQPTQQ-------------QHTIQQQLYYPTQQQPQVPAPAEPALDSFDNNNSGGGG 150
            .|..||||.:|.|:             ..||  .:::..:::..|      .:.|.|..|:....
 Frog   303 VQYPPPQQPEPHQEVPSASGRVSTNADSGTI--SMFFKGEEEENV------EIVSSDQQNASIKA 359

  Fly   151 GGGRSDGWGDWGDWNDNSNNNNSNGTDGLL-EPTGQ----------LLEDSFNVQSSQG------ 198
            ..|.|           :..|....|...|| :||..          |.....:|.||.|
 Frog   360 DLGSS-----------HYQNAGYQGVSSLLPQPTVSSGIPAMTPITLASGVPHVPSSAGNATHPH 413

  Fly   199 -SWQAFATS-------------NNVNN-----NGEL---------PPPANPQSTSLQQQPLNQQS 235
             :|:.....             :||.|     |.|:         |.|.|..|.:.:..|:....
 Frog   414 SAWRQDTLPLRDNTAKPREMPYDNVENIECVQNQEVLPNEPNHFNPYPPNVTSDAYRYGPVPGPP 478

  Fly   236 IPL-LHQQPQSPPELGQEPELDAIVPPQA----FQNQPPTAAPPPT------------------- 276
            :|. :...|:..|.|.....:...|.|.:    :.|....:.|.||
 Frog   479 LPKNVSGHPEVGPNLETPDTVGCPVRPDSVSSNYSNLSLKSLPVPTRSQEHAGTFIQKESGRLEG 543

  Fly   277 -SLTSFSAQMTAVGSPIY--AVGAS-------SAHSAGVGASPAPPTGVVAPPAHLAGIGAPPAH 331
             |..||..|:.:  ||:.  |||.:       |:.|.....||..|||:....|: :......:|
 Frog   544 DSSHSFFKQIDS--SPMTGDAVGQNMGQHKFHSSLSQPPTPSPPKPTGIFMTSAN-SSFEPVRSH 605

  Fly   332 LAGVGASPAPSALVGASPAPIIGVGAPPVGAP-PVGAPPADATTIAPPAALPPSIVPSSGS---- 391
            ..|:..|.|..:.:|.....::...:.||.:| .:..||.:..||..........|.|:||
 Frog   606 SIGLKPSDADQSKMGGEGHKVLQNASIPVASPGNLEQPPDNLETIFLGKRNSHGTVTSNGSLFHS 670

  Fly   392 ---------------NPFKRSTGLNKRV------------------NIMADPAAGAPS---PPAP 420
                           .|..|:.|.:|:.                  |::..||  |||   ||.|
 Frog   671 VGEPPLDNVSLLLDRRPSSRAQGSSKKCESPATTLWAQGELPNFGGNVLLAPA--APSLYVPPKP 733

  Fly   421 AAAIAPVAPVAPIPPPADQLFG-----------------------------------MPAEAHGE 450
            ...|        |.||.|..:.                                   :.::|...
 Frog   734 QTEI--------IQPPEDGSYDSRAGGTDPGKFQASPEEQISSENLENPPKIGDEEQLSSQASSG 790

  Fly   451 GFNLIAAPPVEASLGTPLSAPIPAPIPVPNASLYASPAVPQAFAHLEPDNQEVLSAPNDERAQYL 515
            ..:|:::||.||....|:.      |..||.:.  :.|.|..|:         ||.||
 Frog   791 YASLLSSPPTEALQNQPVL------IAQPNKTY--NLAQPINFS---------LSLPN------- 831

  Fly   516 QTSHLSEQLGEGEADQDAGLLPPPGLSR----------LVLGQPELDSQQ--------------- 555
            |..:::.....|.|::......||.:..          |..|:||:.:|.
 Frog   832 QVKNVNSLKEPGTAEKQGPQSLPPAVGNFSSNENAPFSLTQGRPEVPNQSNYKSAAPNDKFSESL 896

  Fly   556 -------QRQVTGATEQPPLNVAQAAALHMQERRADGEDTSDGEQQVRNIQTPPRRVVTGVETNA 613
                   |||  .:..|.|||:|           |:.:....||....:....     |.:.|.|
 Frog   897 PNQHSVLQRQ--SSANQAPLNLA-----------AESQKVPMGENATVDFANK-----TAIPTTA 943

  Fly   614 -------------PSLREQREVVLDGENLEDREAIPPPTLAELPTTSVHHNILPDEAEQLHHNNP 665
                         ||...::...||.            |:...|.:||.:|:...       |:.
 Frog   944 PMGPRFPANPNCRPSYPAEKSGALDF------------TVPRAPLSSVANNVALS-------NSQ 989

  Fly   666 PQAMTPLNAQQPHQQQSTLQQQHQQHSTTQQEKKRAAVGRRT-TASLDLESDESDEFLQSERERD 729
            |.|..||...||                         ||.:. .|.||:  ::...:.|..::..
 Frog   990 PVAGGPLVPGQP-------------------------VGAQNGQAGLDI--NKQGFYQQVTKDGP 1027

  Fly   730 RERERRDLMEERHSRG---------RSHS----------------HYPYEGETE----DSVRGAA 765
            .::..:|:   .|..|         .||.                .||.:.|::    .:..||.
 Frog  1028 PQQPAKDI---PHHGGVAPQEYMVPASHPLPLVPPAQAPPGGKPVSYPLQAESQVPASQNPIGAP 1089

  Fly   766 HHETKSLRETHHK----------------------RNHDSARSRRHQDPKVERERERD------- 801
            ::   |..|...|                      .||.:....:.:.|.....::.|
 Frog  1090 YN---SAPEPAPKYGPTEQPPYPAQPVPSSSAPVNLNHTATYQEQPRPPASHTPQQADPYYYYRS 1151

  Fly   802 ---------RERDRTWRRRSNKYHSGGEDPDRSYDHS-RRYNNSNYEGESDNPEYNHMGDAELDG 856
                     :...:...|.:..|:   :||..:||.: |:|:.:.|......|
 Frog  1152 YGAYPQPYGQPYQQVDPRAAPLYY---QDPYGAYDPAYRQYSGTAYANPGKYP------------ 1201

  Fly   857 SGGRSSKTSRHRRSAAEEDFDDYERERNRSR----RSTKPQSSAEKSRSSGGRRNYENSGRSARA 917
                               :.:.||..:||.    |.:..|..:.||..||....|..| :...|
 Frog  1202 -------------------YQEPERPSSRSSHCSDRPSSRQGYSSKSDWSGYYPGYYQS-QYDYA 1246

  Fly   918 DDGR-RRYQDQRNPGAQYPVSATGYVPYGMYEQMSRNPQVYADMYAKFYGQMINSMNAAVSAAAS 981
            |..| .||....:||                         |.|..:.::..|.||.:.|.
 Frog  1247 DPARWDRYPAAYDPG-------------------------YRDPRSNYWNYMYNSRDDAY----- 1281

  Fly   982 KGGVPAGAGVIPGLMPSAVPVSAAQLVAATSGGSVSGSSEAAMLRERERYTHAYI---------- 1036
            :..|||                     |.||...|        ..:|.:|...|:
 Frog  1282 QRNVPA---------------------AYTSRYDV--------YEDRWQYDPRYVGGFDDEPQRD 1317

  Fly  1037 TQANEFHRHQYKELIYQQQQQQQQQQQQQQQREDH-LNSSFSVAEDNASFYGSHGG--GSIYN-Q 1097
            ...::|.|...        ..:.........|.:| ..||||....::..|.|...  .|.|. |
 Frog  1318 LAKDDFDRRSI--------HSEHSAHSMHSGRSNHSRRSSFSSHSQHSQIYKSQPDLTASAYEPQ 1374

  Fly  1098 YQSYPLSSARSLSNLNGDGRNSRCGPY---YAGSECGLDIRAAADAAPSTYGGVAGTA-GPVTNT 1158
            .|:.||:             ....|.|   |:..: |||        ..:||....|. .||...
 Frog  1375 IQNPPLN-------------EYSYGMYPNDYSAQQ-GLD--------NYSYGYPKATEWQPVEQV 1417

  Fly  1159 AVARPPRRRTPLQFSRPHLVASYAM-SLLLKVKPKYAGRGR------------LRNDVEVAPPRI 1210
                |.|..||.:|..||:.|.:.. ..|:||.|.....|:            ::|..|
 Frog  1418 ----PSRPLTPEKFGSPHVCARFGPGGQLIKVLPNLPSDGQPALVEIHNMEVVMQNSAE------ 1472

  Fly  1211 RDGTSSLLRMYPGPLQGRKLHKDKIISFCKEQIRLGPTKGCTALYATQKKPQGSVTKYRASHALM 1275
                ...||.:||||...:.||..:|:|.:::     :|.|:         |......:.|..|:
 Frog  1473 ----QEQLRAFPGPLVKDETHKVDVINFAQKK-----SKECS---------QNESLLDQESACLV 1519

  Fly  1276 WHLLILLLRQNGYIADTDVGDLLLENQQ------EYPYDPSEFEAENEPDADAEQDAAAPADKTV 1334
            |..::||.||||.:..||:.:|||.:.:      :.|.:.:..:..|||....|:::.|.....:
 Frog  1520 WDFIVLLCRQNGTVVGTDIAELLLRDHKTVWLPGKSPNEANLIDFSNEPLEQREEESGASQLSFL 1584

  Fly  1335 DSDLDSESAAGVTPAEPLAAGAATSSINGADAANAATPLSEQAATDKFRSYVLRGNVEEALQWAT 1399
            ...|.|...|                            |.::  |::||..:|.|..::||:.|.
 Frog  1585 TDTLQSTGEA----------------------------LEKE--TERFRELLLFGRKKDALESAM 1619

  Fly  1400 DNGLWTHAFFLALYEDRYALTDVAQKFLNRAIKANDPLQTLYQMKSCHTPACVSQLRDEQWGDWR 1464
            ..|||.||..||...|......|..:|.| ::..||||||:||:.|...||..:...||:|||||
 Frog  1620 KTGLWGHALLLASKMDSRTHARVMTRFAN-SLPINDPLQTVYQLLSGRMPAAATCCGDEKWGDWR 1683

  Fly  1465 SHLSILVTNKSRQPEYDRSSVVALGDTLFQRGDIYAAHFCYLVAQEEFGRYDSSATELTTLTANV 1529
            .||:::::|.:...:....::.|:||||..||.:.|:|.|||:||..||.:...:|
 Frog  1684 PHLAMVLSNLTNNVDVPTRAMTAMGDTLASRGLLDASHVCYLMAQVGFGIFTKKST--------- 1739

  Fly  1530 PRLILLGSSHYKHFNEFASNEAIIMTEIYEYARSLFDPKFSIAHFQHYKFLLATRILDYGQHFRC 1594
             :|:|:||:|...|..|.:||||..||.||||:||....||:.:.|.|||:.|.|:.::|...:.
 Frog  1740 -KLVLIGSNHSLSFARFCTNEAIQRTEAYEYAQSLGTQSFSLPNIQVYKFIYACRLAEHGLSAQA 1803

  Fly  1595 TNYLEQIARHIELKPESYDSNFIQRVCGLAERLRYHDPILINRVS---FASPPNATSKDSAAAEE 1656
            .:|.|.|::.:...|..|....:.::..::..||:.||.|..:..   |..||
 Frog  1804 FHYCEVISKTVLRHPSCYSPVLVSQLLEVSSHLRFCDPQLKEKPEQELFIDPP------------ 1856

  Fly  1657 KAWLRQLRSLAYVQPQQEQLQQLQQNQQVQQEQNDIDQQFAEVNKQFRELNMQYESNS------- 1714
              ||:.||:|.         ||::....|........||||   ......:|.:.|.|
 Frog  1857 --WLQHLRTLD---------QQMKHGTVVYDTGRTTPQQFA---CSTPSSDMDHVSQSDGAGTAA 1907

  Fly  1715 ----NMENTLQPQLPPVDQQPPQQQQQVLSESYQQPTQQYYEPPPQAPTESDPYGQGQPSYYDPN 1775
                :.:|.|...|.| :..|| .|..::....:.|...|    |..| .:||...|.|....|:
 Frog  1908 DVPTHTDNPLLASLLP-NMMPP-VQAVLVPAGPENPAPMY----PSYP-GNDPSHPGTPQGLAPS 1965

  Fly  1776 AGQLHYDPNAAQHQYDQQQPQPQPTPSYGQIEPGTEAYQPGQATADPAAVPSGYGYDYWSGTQQP 1840
            :|                    .|||                ||| |..||.|       |.|.|
 Frog  1966 SG--------------------PPTP----------------ATA-PGFVPFG-------GEQAP 1986

  Fly  1841 PYGDEPNENQAALKDEEEEDEEQDEQQILQYA-KQQILQQTKQQQLQQEQHTRSN---------G 1895
            .|  .|...|..|...:..|          || ..|:.|....|::||...|::.         |
 Frog  1987 IY--PPAPLQPYLPPPQAAD----------YAPPMQMNQDPGLQRIQQNSPTKTTFHDPEVDFYG 2039

  Fly  1896 A-ASINNRFKSNALKQERSSGSLRKRQEASRTAT--IAAAAAAIAQITPATVAAAATPPAASAKA 1957
            . |.:....:|..:.|  ||..:|:.:..|.::|  |.:...:...|.|      :.||...|..
 Frog  2040 VMAKMGPGQRSRTVSQ--SSSHMRRTRTTSESSTHSIGSGRRSSMSIQP------SPPPIPEADR 2096

  Fly  1958 FNLNDVSSFSSTNKRH--QATSSSNNRS------------SSNQAAAAAAATKAAAIATVPAAPN 2008
                     :...|.|  :..|..:.||            ..|:|.......|:   ........
 Frog  2097 ---------AEEKKEHKPRGPSQGSGRSWFPLKFGWLMGKGKNEAHLPDDRNKS---IVWDEKKQ 2149

  Fly  2009 QLLSCRKSNSQNSPYLATP-----KTLTTPTRFIAAKAATVTATPTAPATSTTTSTTIGARG 2065
            :.::..:...::.|....|     |..:||         .|...|..|:.:..:....||||
 Frog  2150 KWVNMDEPEEESKPLPPPPPGMLKKPQSTP---------AVPGGPPNPSVNVFSIRAAGARG 2202

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec16	NP_001285158.1	ACE1-Sec16-like	1371..1631	CDD:187750	93/259 (36%)
sec16a	XP_004916695.2	PRK12323	<37..>246	CDD:237057	19/71 (27%)
		PHA03247	<719..1172	CDD:223021	94/556 (17%)
		ACE1-Sec16-like	1479..1840	CDD:187750	127/415 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	165	1.000	Domainoid score	I3861
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	263	1.000	Inparanoid score	I3004
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001693
OrthoInspector	1	1.000	-	-		otm49091
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.050