Protein Alignment CG1824 and ABCB11

DIOPT Version :10

• Sequence 1: NP_572810.1
• Gene: CG1824 / 32208
• FlyBaseID: FBgn0030403
• Length: 761
• Species: Drosophila melanogaster
• Sequence 2: XP_011510380.1
• Gene: ABCB11 / 8647
• HGNCID: 42
• Length: 1355
• Species: Homo sapiens
• Alignment Length: 592
• Identity: 208/592 - (35%)
• Similarity: 310/592 - (52%)
• Gaps: 46/592 - (7%)

  Fly   123 WTYLEPHLWELIGAVCAALIVAYINIRIPNLLGDLVNTLARYANTYVMDPINNSF-VKDVSKPAS 186
            |.|:      |:|:|.||                 ||........::...|..:| :.|..:..|
Human   786 WPYM------LVGSVGAA-----------------VNGTVTPLYAFLFSQILGTFSIPDKEEQRS 827

  Fly   187 NLLSLYML------QSGFT-FMYIYLLSRVGEQMAAKMRQDLFTQIVVQDIAFFDE--NRTGELV 242
            .:..:.:|      .|.|| |:..|..::.||.:..::|:..|..::.||||:||:  |..|.|.
Human   828 QINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDDLRNSPGALT 892

  Fly   243 NRLTADVQDFKTSFKQFVSQGLRSAAQLIGGSISLFMISPHMAAIALASVPCVVMFMTYLGKKLR 307
            .||..|....:.:....:...:.|...:....|..|..|..::.:.|...|.:.:......:.|.
Human   893 TRLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKLSLVILCFFPFLALSGATQTRMLT 957

  Fly   308 SLSKSSQAQAERATGVCEEALSNIRTVRSSACEYREMQLFEAETNEAARLA-QKLG-YGIAI-FQ 369
            ..:...:...|....:..|||||||||.....|.|.::..|.|..:..:.| ||.. ||... |.
Human   958 GFASRDKQALEMVGQITNEALSNIRTVAGIGKERRFIEALETELEKPFKTAIQKANIYGFCFAFA 1022

  Fly   370 GLTNFFLNTLVLSTLFMGGHLMSTESLSPGALMAFLVASQGVQRSLAQGSILLGT--MIRGMSAG 432
            ....|..|:   ::...||:|:|.|.|.  ....|.|.|..|..:.|.|.....|  ..:...:.
Human  1023 QCIMFIANS---ASYRYGGYLISNEGLH--FSYVFRVISAVVLSATALGRAFSYTPSYAKAKISA 1082

  Fly   433 SRVFEFLSLQPQVELLRGYIIPQERLHGEIRFENVSFAYPMQPDHLVLKDFSLTLRPGQTVALVG 497
            :|.|:.|..||.:.:........:...|:|.|.:..|.||.:||..||...|:::.||||:|.||
Human  1083 ARFFQLLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQTLAFVG 1147

  Fly   498 ASGSGKSTIASLVERFYEPSAGNIKLDGYKLSDISPYWLRSNVLGFIEQQPVLFGTSILENIRYG 562
            :||.||||...|:||||:|..|.:.:||:....::..:||||: |.:.|:||||..||::||:||
Human  1148 SSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNI-GIVSQEPVLFACSIMDNIKYG 1211

  Fly   563 --KPDAGEEDVYAAARLSQSHDFVTALPDGYATHVGERGTQLSGGQRQRIAIARALLKNPRILIL 625
              ..:...|.|.|||:.:|.||||.:||:.|.|:||.:|:|||.|::||||||||::::|:||:|
Human  1212 DNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLL 1276

  Fly   626 DEATSALDATSEAEVQKALDTVVQNRTTLVIAHRLSTIRNADLIVVLDQGRVVETGKHDELMGKR 690
            ||||||||..||..||.|||...:.||.:|||||||||:|||:|.|:.||.|:|.|.|:|||.::
Human  1277 DEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQK 1341

  Fly   691 GLYFELV 697
            |.|::||
Human  1342 GAYYKLV 1348

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1824	NP_572810.1	MdlB	119..702	CDD:440747	208/592 (35%)
ABCB11	XP_011510380.1	PTZ00265	52..1348	CDD:240339	206/590 (35%)
		MdlB	773..1350	CDD:440747	208/592 (35%)